1,664 research outputs found
Extracting fetal heart beats from maternal abdominal recordings: Selection of the optimal principal components
This study presents a systematic comparison of different approaches to the automated selection of the principal components (PC) which optimise the detection of maternal and fetal heart beats from non-invasive maternal abdominal recordings. A public database of 75 4-channel non-invasive maternal abdominal recordings was used for training the algorithm. Four methods were developed and assessed to determine the optimal PC: (1) power spectral distribution, (2) root mean square, (3) sample entropy, and (4) QRS template. The sensitivity of the performance of the algorithm to large-amplitude noise removal (by wavelet de-noising) and maternal beat cancellation methods were also assessed. The accuracy of maternal and fetal beat detection was assessed against reference annotations and quantified using the detection accuracy score F1 [2*PPV*Se / (PPV + Se)], sensitivity (Se), and positive predictive value (PPV). The best performing implementation was assessed on a test dataset of 100 recordings and the agreement between the computed and the reference fetal heart rate (fHR) and fetal RR (fRR) time series quantified. The best performance for detecting maternal beats (F1 99.3%, Se 99.0%, PPV 99.7%) was obtained when using the QRS template method to select the optimal maternal PC and applying wavelet de-noising. The best performance for detecting fetal beats (F1 89.8%, Se 89.3%, PPV 90.5%) was obtained when the optimal fetal PC was selected using the sample entropy method and utilising a fixed-length time window for the cancellation of the maternal beats. The performance on the test dataset was 142.7 beats2/min2 for fHR and 19.9 ms for fRR, ranking respectively 14 and 17 (out of 29) when compared to the other algorithms presented at the Physionet Challenge 2013
Novel hybrid extraction systems for fetal heart rate variability monitoring based on non-invasive fetal electrocardiogram
This study focuses on the design, implementation and subsequent verification of a new type of hybrid extraction system for noninvasive fetal electrocardiogram (NI-fECG) processing. The system designed combines the advantages of individual adaptive and non-adaptive algorithms. The pilot study reviews two innovative hybrid systems called ICA-ANFIS-WT and ICA-RLS-WT. This is a combination of independent component analysis (ICA), adaptive neuro-fuzzy inference system (ANFIS) algorithm or recursive least squares (RLS) algorithm and wavelet transform (WT) algorithm. The study was conducted on clinical practice data (extended ADFECGDB database and Physionet Challenge 2013 database) from the perspective of non-invasive fetal heart rate variability monitoring based on the determination of the overall probability of correct detection (ACC), sensitivity (SE), positive predictive value (PPV) and harmonic mean between SE and PPV (F1). System functionality was verified against a relevant reference obtained by an invasive way using a scalp electrode (ADFECGDB database), or relevant reference obtained by annotations (Physionet Challenge 2013 database). The study showed that ICA-RLS-WT hybrid system achieve better results than ICA-ANFIS-WT. During experiment on ADFECGDB database, the ICA-RLS-WT hybrid system reached ACC > 80 % on 9 recordings out of 12 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 6 recordings out of 12. During experiment on Physionet Challenge 2013 database the ICA-RLS-WT hybrid system reached ACC > 80 % on 13 recordings out of 25 and the ICA-ANFIS-WT hybrid system reached ACC > 80 % only on 7 recordings out of 25. Both hybrid systems achieve provably better results than the individual algorithms tested in previous studies.Web of Science713178413175
Hybrid methods based on empirical mode decomposition for non-invasive fetal heart rate monitoring
This study focuses on fetal electrocardiogram (fECG) processing using hybrid methods that combine two or more individual methods. Combinations of independent component analysis (ICA), wavelet transform (WT), recursive least squares (RLS), and empirical mode decomposition (EMD) were used to create the individual hybrid methods. Following four hybrid methods were compared and evaluated in this study: ICA-EMD, ICA-EMD-WT, EMD-WT, and ICA-RLS-EMD. The methods were tested on two databases, the ADFECGDB database and the PhysioNet Challenge 2013 database. Extraction evaluation is based on fetal heart rate (fHR) determination. Statistical evaluation is based on determination of correct detection (ACC), sensitivity (Se), positive predictive value (PPV), and harmonic mean between Se and PPV (F1). In this study, the best results were achieved by means of the ICA-RLS-EMD hybrid method, which achieved accuracy(ACC) > 80% at 9 out of 12 recordings when tested on the ADFECGDB database, reaching an average value of ACC > 84%, Se > 87%, PPV > 92%, and F1 > 90%. When tested on the Physionet Challenge 2013 database, ACC > 80% was achieved at 12 out of 25 recordings with an average value of ACC > 64%, Se > 69%, PPV > 79%, and F1 > 72%.Web of Science8512185120
Efficient fetal-maternal ECG signal separation from two channel maternal abdominal ECG via diffusion-based channel selection
There is a need for affordable, widely deployable maternal-fetal ECG monitors
to improve maternal and fetal health during pregnancy and delivery. Based on
the diffusion-based channel selection, here we present the mathematical
formalism and clinical validation of an algorithm capable of accurate
separation of maternal and fetal ECG from a two channel signal acquired over
maternal abdomen
Fetal electrocardiograms, direct and abdominal with reference heartbeat annotations
Monitoring fetal heart rate (FHR) variability plays a fundamental role in fetal state assessment. Reliable FHR signal can be obtained from an invasive direct fetal electrocardiogram (FECG), but this is limited to labour. Alternative abdominal (indirect) FECG signals can be recorded during pregnancy and labour. Quality, however, is much lower and the maternal heart and uterine contractions provide sources of interference. Here, we present ten twenty-minute pregnancy signals and 12 five-minute labour signals. Abdominal FECG and reference direct FECG were recorded simultaneously during labour. Reference pregnancy signal data came from an automated detector and were corrected by clinical experts. The resulting dataset exhibits a large variety of interferences and clinically significant FHR patterns. We thus provide the scientific community with access to bioelectrical fetal heart activity signals that may enable the development of new methods for FECG signals analysis, and may ultimately advance the use and accuracy of abdominal electrocardiography methods.Web of Science71art. no. 20
Estrazione non invasiva del segnale elettrocardiografico fetale da registrazioni con elettrodi posti sull’addome della gestante (Non-invasive extraction of the fetal electrocardiogram from abdominal recordings by positioning electrodes on the pregnant woman’s abdomen)
openIl cuore è il primo organo che si sviluppa nel feto, particolarmente nelle primissime settimane di
gestazione. Rispetto al cuore adulto, quello fetale ha una fisiologia ed un’anatomia significativamente
differenti, a causa della differente circolazione cardiovascolare. Il benessere fetale si valuta
monitorando l’attività cardiaca mediante elettrocardiografia fetale (ECGf). L’ECGf invasivo (acquisito
posizionando elettrodi allo scalpo fetale) è considerato il gold standard, ma l’invasività che lo
caratterizza ne limita la sua applicabilità. Al contrario, l’uso clinico dell’ECGf non invasivo (acquisito
posizionando elettrodi sull’addome della gestante) è limitato dalla scarsa qualità del segnale risultante.
L’ECGf non invasivo si estrae da registrazioni addominali, che sono corrotte da differenti tipi di rumore,
fra i quali l’interferenza primaria è rappresentata dall’ECG materno. Il Segmented-Beat Modulation
Method (SBMM) è stato da me recentemente proposto come una nuova procedura di filtraggio basata
sul calcolo del template del battito cardiaco. SBMM fornisce una stima ripulita dell’ECG estratto da
registrazioni rumorose, preservando la fisiologica variabilità ECG del segnale originale. Questa
caratteristica è ottenuta grazie alla segmentazione di ogni battito cardiaco per indentificare i segmenti
QRS e TUP, seguito dal processo di modulazione/demodulazione (che include strecciamento e
compressione) del segmento TUP, per aggiustarlo in modo adattativo alla morfologia e alla durata di
ogni battito originario. Dapprima applicato all’ECG adulto al fine di dimostrare la sua robustezza al
rumore, l’SBMM è stato poi applicato al caso fetale. Particolarmente significativi sono i risultati relativi
alle applicazioni su ECGf non invasivo, dove l’SBMM fornisce segnali caratterizzati da un rapporto
segnale-rumore comparabile a quello caratterizzante l’ECGf invasivo. Tuttavia, l’SBMM può
contribuire alla diffusione dell’ECGf non invasiva nella pratica clinica.The heart is the first organ that develops in the fetus, particularly in the very early stages
of pregnancy. Compared to the adult heart, the physiology and anatomy of the fetal heart
exhibit some significant differences. These differences originate from the fact that the fetal
cardiovascular circulation is different from the adult circulation. Fetal well-being
evaluation may be accomplished by monitoring cardiac activity through fetal
electrocardiography (fECG). Invasive fECG (acquired through scalp electrodes) is the
gold standard but its invasiveness limits its clinical applicability. Instead, clinical use of
non-invasive fECG (acquired through abdominal electrodes) has so far been limited by its
poor signal quality. Non-invasive fECG is extracted from the abdominal recording and is
corrupted by different kind of noise, among which maternal ECG is the main interference.
The Segmented-Beat Modulation Method (SBMM) was recently proposed by myself as a
new template-based filtering procedure able to provide a clean ECG estimation from a
noisy recording by preserving physiological ECG variability of the original signal. The
former feature is achieved thanks to a segmentation procedure applied to each cardiac
beat in order to identify the QRS and TUP segments, followed by a
modulation/demodulation process (involving stretching and compression) of the TUP
segments to adaptively adjust each estimated cardiac beat to the original beat morphology
and duration. SBMM was first applied to adult ECG applications, in order to demonstrate
its robustness to noise, and then to fECG applications. Particularly significant are the
results relative to the non-invasive applications, where SBMM provided fECG signals
characterized by a signal-to-noise ratio comparable to that characterizing invasive fECG.
Thus, SBMM may contribute to the spread of this noninvasive fECG technique in the
clinical practice.INGEGNERIA DELL'INFORMAZIONEAgostinelli, AngelaAgostinelli, Angel
A clustering-based method for single-channel fetal heart rate monitoring
Non-invasive fetal electrocardiography (ECG) is based on the acquisition of signals from
abdominal surface electrodes. The composite abdominal signal consists of the maternal
electrocardiogram along with the fetal electrocardiogram and other electrical interferences.
These recordings allow for the acquisition of valuable and reliable information that helps
ensure fetal well-being during pregnancy. This paper introduces a procedure for fetal heart
rate extraction from a single-channel abdominal ECG signal. The procedure is composed of
three main stages: a method based on wavelet for signal denoising, a new clustering-based
methodology for detecting fetal QRS complexes, and a final stage to correct false positives
and false negatives. The novelty of the procedure thus relies on using clustering techniques
to classify singularities from the abdominal ECG into three types: maternal QRS complexes,
fetal QRS complexes, and noise. The amplitude and time distance of all the local maxima
followed by a local minimum were selected as features for the clustering classification. A
wide set of real abdominal ECG recordings from two different databases, providing a large
range of different characteristics, was used to illustrate the efficiency of the proposed
method. The accuracy achieved shows that the proposed technique exhibits a competitve
performance when compared to other recent works in the literature and a better performance
over threshold-based techniques.This work has been partially funded by
Banco Santander and Centro Mixto UGR-MADOC
through project SIMMA (code 2/16). The
contribution of Antonio García has been partially
funded by Spain's Ministerio de Educación, Cultura
y Deporte (Programa Estatal de Promoción del
Talento y su Empleabilidad en I+D+i, Subprograma
Estatal de Movilidad, within Plan Estatal de
Investigación Científica y Técnica y de Innovación 2013-2016) under a "Salvador de Madariaga" grant
(PRX17/00287)
Advances in Digital Processing of Low-Amplitude Components of Electrocardiosignals
This manual has been published within the framework of the BME-ENA project under the responsibility of National Technical University of Ukraine. The BME-ENA “Biomedical Engineering Education Tempus Initiative in Eastern Neighbouring Area”, Project Number: 543904-TEMPUS-1-2013-1-GR-TEMPUS-JPCR is a Joint Project within the TEMPUS IV program. This project has been funded with support from the European Commission.Навчальний посібник присвячено розробці методів та засобів для неінвазивного виявлення та дослідження тонких проявів електричної активності серця. Особлива увага приділяється вдосконаленню інформаційного та алгоритмічного забезпечення систем електрокардіографії високого розрізнення для ранньої діагностики електричної нестабільності міокарда, а також для оцінки функціонального стану плоду під час вагітності.
Теоретичні основи супроводжуються прикладами реалізації алгоритмів за допомогою системи MATLAB. Навчальний посібник призначений для студентів, аспірантів, а також фахівців у галузі біомедичної електроніки та медичних працівників.The teaching book is devoted to development and research of methods and tools for non-invasive detection of subtle manifistations of heart electrical activity. Particular attention is paid to the improvement of information and algorithmic support of high resolution electrocardiography for early diagnosis of myocardial electrical instability, as well as for the evaluation of the functional state of the fetus during pregnancy examination.
The theoretical basis accompanied by the examples of implementation of the discussed algorithms with the help of MATLAB. The teaching book is intended for students, graduate students, as well as specialists in the field of biomedical electronics and medical professionals
Detection and Processing Techniques of FECG Signal for Fetal Monitoring
Fetal electrocardiogram (FECG) signal contains potentially precise information that could assist clinicians in making more appropriate and timely decisions during labor. The ultimate reason for the interest in FECG signal analysis is in clinical diagnosis and biomedical applications. The extraction and detection of the FECG signal from composite abdominal signals with powerful and advance methodologies are becoming very important requirements in fetal monitoring. The purpose of this review paper is to illustrate the various methodologies and developed algorithms on FECG signal detection and analysis to provide efficient and effective ways of understanding the FECG signal and its nature for fetal monitoring. A comparative study has been carried out to show the performance and accuracy of various methods of FECG signal analysis for fetal monitoring. Finally, this paper further focused some of the hardware implementations using electrical signals for monitoring the fetal heart rate. This paper opens up a passage for researchers, physicians, and end users to advocate an excellent understanding of FECG signal and its analysis procedures for fetal heart rate monitoring system
- …