Data-driven multivariate and multiscale methods for brain computer interface

This thesis focuses on the development of data-driven multivariate and multiscale methods for brain computer interface (BCI) systems. The electroencephalogram (EEG), the most convenient means to measure neurophysiological activity due to its noninvasive nature, is mainly considered. The nonlinearity and nonstationarity inherent in EEG and its multichannel recording nature require a new set of data-driven multivariate techniques to estimate more accurately features for enhanced BCI operation. Also, a long term goal is to enable an alternative EEG recording strategy for achieving long-term and portable monitoring. Empirical mode decomposition (EMD) and local mean decomposition (LMD), fully data-driven adaptive tools, are considered to decompose the nonlinear and nonstationary EEG signal into a set of components which are highly localised in time and frequency. It is shown that the complex and multivariate extensions of EMD, which can exploit common oscillatory modes within multivariate (multichannel) data, can be used to accurately estimate and compare the amplitude and phase information among multiple sources, a key for the feature extraction of BCI system. A complex extension of local mean decomposition is also introduced and its operation is illustrated on two channel neuronal spike streams. Common spatial pattern (CSP), a standard feature extraction technique for BCI application, is also extended to complex domain using the augmented complex statistics. Depending on the circularity/noncircularity of a complex signal, one of the complex CSP algorithms can be chosen to produce the best classification performance between two different EEG classes. Using these complex and multivariate algorithms, two cognitive brain studies are investigated for more natural and intuitive design of advanced BCI systems. Firstly, a Yarbus-style auditory selective attention experiment is introduced to measure the user attention to a sound source among a mixture of sound stimuli, which is aimed at improving the usefulness of hearing instruments such as hearing aid. Secondly, emotion experiments elicited by taste and taste recall are examined to determine the pleasure and displeasure of a food for the implementation of affective computing. The separation between two emotional responses is examined using real and complex-valued common spatial pattern methods. Finally, we introduce a novel approach to brain monitoring based on EEG recordings from within the ear canal, embedded on a custom made hearing aid earplug. The new platform promises the possibility of both short- and long-term continuous use for standard brain monitoring and interfacing applications

Applications of Blind Source Separation to the Magnetoencephalogram Background Activity in Alzheimer’s Disease

En esta Tesis Doctoral se ha analizado actividad basal de magnetoencefalograma (MEG) de 36 pacientes con la Enfermedad de Alzheimer (Alzheimer’s Disease, AD) y 26 sujetos de control de edad avanzada con técnicas de separación ciega de fuentes (Blind Source Separation, BSS). El objetivo era aplicar los métodos de BSS para ayudar en el análisis e interpretación de este tipo de actividad cerebral, prestando especial atención a la AD. El término BSS denota un conjunto de técnicas útiles para descomponer registros multicanal en las componentes que los dieron lugar. Cuatro diferentes aplicaciones han sido desarrolladas. Los resultados de esta Tesis Doctoral sugieren la utilidad de la BSS para ayudar en el procesado de la actividad basal de MEG y para identificar y caracterizar la AD.Departamento de Teoría de la Señal y Comunicaciones e Ingeniería Telemátic

Analysis of Signal Decomposition and Stain Separation methods for biomedical applications

Nowadays, the biomedical signal processing and classification and medical image interpretation play an essential role in the detection and diagnosis of several human diseases. The problem of high variability and heterogeneity of information, which is extracted from digital data, can be addressed with signal decomposition and stain separation techniques which can be useful approaches to highlight hidden patterns or rhythms in biological signals and specific cellular structures in histological color images, respectively. This thesis work can be divided into two macro-sections. In the first part (Part I), a novel cascaded RNN model based on long short-term memory (LSTM) blocks is presented with the aim to classify sleep stages automatically. A general workflow based on single-channel EEG signals is developed to enhance the low performance in staging N1 sleep without reducing the performances in the other sleep stages (i.e. Wake, N2, N3 and REM). In the same context, several signal decomposition techniques and time-frequency representations are deployed for the analysis of EEG signals. All extracted features are analyzed by using a novel correlation-based timestep feature selection and finally the selected features are fed to a bidirectional RNN model. In the second part (Part II), a fully automated method named SCAN (Stain Color Adaptive Normalization) is proposed for the separation and normalization of staining in digital pathology. This normalization system allows to standardize digitally, automatically and in a few seconds, the color intensity of a tissue slide with respect to that of a target image, in order to improve the pathologist’s diagnosis and increase the accuracy of computer-assisted diagnosis (CAD) systems. Multiscale evaluation and multi-tissue comparison are performed for assessing the robustness of the proposed method. In addition, a stain normalization based on a novel mathematical technique, named ICD (Inverse Color Deconvolution) is developed for immunohistochemical (IHC) staining in histopathological images. In conclusion, the proposed techniques achieve satisfactory results compared to state-of-the-art methods in the same research field. The workflow proposed in this thesis work and the developed algorithms can be employed for the analysis and interpretation of other biomedical signals and for digital medical image analysis

EEG-based multi-modal emotion recognition using bag of deep features: An optimal feature selection approach

Much attention has been paid to the recognition of human emotions with the help of electroencephalogram (EEG) signals based on machine learning technology. Recognizing emotions is a challenging task due to the non-linear property of the EEG signal. This paper presents an advanced signal processing method using the deep neural network (DNN) for emotion recognition based on EEG signals. The spectral and temporal components of the raw EEG signal are first retained in the 2D Spectrogram before the extraction of features. The pre-trained AlexNet model is used to extract the raw features from the 2D Spectrogram for each channel. To reduce the feature dimensionality, spatial, and temporal based, bag of deep features (BoDF) model is proposed. A series of vocabularies consisting of 10 cluster centers of each class is calculated using the k-means cluster algorithm. Lastly, the emotion of each subject is represented using the histogram of the vocabulary set collected from the raw-feature of a single channel. Features extracted from the proposed BoDF model have considerably smaller dimensions. The proposed model achieves better classification accuracy compared to the recently reported work when validated on SJTU SEED and DEAP data sets. For optimal classification performance, we use a support vector machine (SVM) and k-nearest neighbor (k-NN) to classify the extracted features for the different emotional states of the two data sets. The BoDF model achieves 93.8% accuracy in the SEED data set and 77.4% accuracy in the DEAP data set, which is more accurate compared to other state-of-the-art methods of human emotion recognition. - 2019 by the authors. Licensee MDPI, Basel, Switzerland.Funding: This research was funded by Higher Education Commission (HEC): Tdf/67/2017.Scopu

Neural correlates of true and false memory in mild cognitive impairment

The goal of this research was to investigate the changes in neural processing in mild cognitive impairment. We measured phase synchrony, amplitudes, and event-related potentials in veridical and false memory to determine whether these differed in participants with mild cognitive impairment compared with typical, age-matched controls. Empirical mode decomposition phase locking analysis was used to assess synchrony, which is the first time this analysis technique has been applied in a complex cognitive task such as memory processing. The technique allowed assessment of changes in frontal and parietal cortex connectivity over time during a memory task, without a priori selection of frequency ranges, which has been shown previously to influence synchrony detection. Phase synchrony differed significantly in its timing and degree between participant groups in the theta and alpha frequency ranges. Timing differences suggested greater dependence on gist memory in the presence of mild cognitive impairment. The group with mild cognitive impairment had significantly more frontal theta phase locking than the controls in the absence of a significant behavioural difference in the task, providing new evidence for compensatory processing in the former group. Both groups showed greater frontal phase locking during false than true memory, suggesting increased searching when no actual memory trace was found. Significant inter-group differences in frontal alpha phase locking provided support for a role for lower and upper alpha oscillations in memory processing. Finally, fronto-parietal interaction was significantly reduced in the group with mild cognitive impairment, supporting the notion that mild cognitive impairment could represent an early stage in Alzheimer’s disease, which has been described as a ‘disconnection syndrome’

Advances in Neural Signal Processing

Neural signal processing is a specialized area of signal processing aimed at extracting information or decoding intent from neural signals recorded from the central or peripheral nervous system. This has significant applications in the areas of neuroscience and neural engineering. These applications are famously known in the area of brain–machine interfaces. This book presents recent advances in this flourishing field of neural signal processing with demonstrative applications

Advances in Neural Signal Processing

Neural signal processing is a specialized area of signal processing aimed at extracting information or decoding intent from neural signals recorded from the central or peripheral nervous system. This has significant applications in the areas of neuroscience and neural engineering. These applications are famously known in the area of brain–machine interfaces. This book presents recent advances in this flourishing field of neural signal processing with demonstrative applications