12 research outputs found
Removal of cardiovascular obstructions by spark erosion
Coronary atherosclerosis, leading to coronary
artery stenosis, is the main cause for ischemic
health disease in the Westem countries. Stenoses
manifest themselves by limiting blood supply to
the myocardium thus causing complaints. A long
history of degenerative atherosclerotic disease of
the intimal wall of the coronary vessels has usually
preceded these events. Probably because of
this long term process the composition of the accumulated
obstructive tissue is quite heterogeneous
and consists of a variety of cells and extra
cellular material like lipid containing macrophages,
smooth muscle cells, Illonocytes, collagen.
cholesterol crystals and calcium. In addition,
fresh or organized thrombi may have been deposited
on these plaques. Regression of these lesions
may be obtained by lifestyle changes or
lipid lowering therapy. The acute invasive removal
of such complex lesions, however, cannot
be achieved by applying simple mechanical or
chemical means
Special Topics in Cardiac Surgery
This book considers mainly the current perioperative care, as well as progresses in new cardiac surgery technologies. Perioperative strategies and new technologies in the field of cardiac surgery will continue to contribute to improvements in postoperative outcomes and enable the cardiac surgical society to optimize surgical procedures. This book should prove to be a useful reference for trainees, senior surgeons and nurses in cardiac surgery, as well as anesthesiologists, perfusionists, and all the related health care workers who are involved in taking care of patients with heart disease which require surgical therapy. I hope these internationally cumulative and diligent efforts will provide patients undergoing cardiac surgery with meticulous perioperative care methods
Cellular Obstruction Clearance in Proximal Ventricular Catheters Using Low-voltage Joule Heating
Objective: Proximal obstruction due to cellular material is a major cause of shunt failure in hydrocephalus management. The standard approach to treat such cases involves surgical intervention which unfortunately is accompanied by inherent surgical risks and a likelihood of future malfunction. We report a prototype design of a proximal ventricular catheter capable of non-invasively clearing cellular obstruction.
Methods: In-vitro cell-culture methods show that low-intensity AC signals successfully destroyed a cellular layer in a localized manner by means of Joule heating induced hyperthermia. A detailed electrochemical model for determining the temperature distribution and ionic current density for an implanted ventricular catheter support our experimental observations.
Results: In-vitro experiments with cells cultured in a plate as well as cells seeded in mock ventricular catheters demonstrated that localized heating between 43ËšC to 48ËšC caused cell death. This temperatures range is consistent with hyperthermia. The electrochemical model verified that Joule heating due to ionic motion is the primary contributor to heat generation.
Conclusion: Hyperthermia induced by Joule heating can clear cellular material in a localized manner. This approach is feasible to design a non-invasive self-clearing ventricular catheter system.
Significance: A shunt system capable of clearing cellular obstruction could significantly reduce the need for future surgical interventions, lower the cost of disease management and improve the quality of life for patients suffering from hydrocephalus
Aerospace Medicine and Biology - A cumulative index to a continuing bibliography
Cumulative index for abstracts of NASA documents on aerospace medicine and biolog
Medical-Data-Models.org:A collection of freely available forms (September 2016)
MDM-Portal (Medical Data-Models) is a meta-data repository for creating, analysing, sharing and reusing medical forms, developed by the Institute of Medical Informatics, University of Muenster in Germany. Electronic forms for documentation of patient data are an integral part within the workflow of physicians. A huge amount of data is collected either through routine documentation forms (EHRs) for electronic health records or as case report forms (CRFs) for clinical trials. This raises major scientific challenges for health care, since different health information systems are not necessarily compatible with each other and thus information exchange of structured data is hampered. Software vendors provide a variety of individual documentation forms according to their standard contracts, which function as isolated applications. Furthermore, free availability of those forms is rarely the case. Currently less than 5 % of medical forms are freely accessible. Based on this lack of transparency harmonization of data models in health care is extremely cumbersome, thus work and know-how of completed clinical trials and routine documentation in hospitals are hard to be re-used. The MDM-Portal serves as an infrastructure for academic (non-commercial) medical research to contribute a solution to this problem. It already contains more than 4,000 system-independent forms (CDISC ODM Format, www.cdisc.org, Operational Data Model) with more than 380,000 dataelements. This enables researchers to view, discuss, download and export forms in most common technical formats such as PDF, CSV, Excel, SQL, SPSS, R, etc. A growing user community will lead to a growing database of medical forms. In this matter, we would like to encourage all medical researchers to register and add forms and discuss existing forms
Proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress
Published proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress, hosted by York University, 27-30 May 2018
Aerospace medicine and biology, an annotated bibliography. volume xi- 1962-1963 literature
Aerospace medicine and biology - annotated bibliography for 1962 and 196