Application of automatic statistical post-processing method for analysis of ultrasonic and digital dermatoscopy images

Ultrasonic and digital dermatoscopy diagnostic methods are used in order to estimate the changes of structure, as well as to non-invasively measure the changes of parameters of lesions of human tissue. These days, it is very actual to perform the quantitative analysis of medical data, which allows to achieve the reliable early-stage diagnosis of lesions and help to save more lives. The proposed automatic statistical post-processing method based on integration of ultrasonic and digital dermatoscopy measurements is intended to estimate the parameters of malignant tumours, measure spatial dimensions (e.g. thickness) and shape, and perform faster diagnostics by increasing the accuracy of tumours differentiation. It leads to optimization of time-consuming analysis procedures of medical images and could be used as a reliable decision support tool in the field of dermatology.Keywords: Ultrasound; digital dermatoscopy; melanoma; ROC analysis; thresholding; Gaussian smoothing; nonparametric statistic

Recent advances in directional statistics

Mainstream statistical methodology is generally applicable to data observed in Euclidean space. There are, however, numerous contexts of considerable scientific interest in which the natural supports for the data under consideration are Riemannian manifolds like the unit circle, torus, sphere and their extensions. Typically, such data can be represented using one or more directions, and directional statistics is the branch of statistics that deals with their analysis. In this paper we provide a review of the many recent developments in the field since the publication of Mardia and Jupp (1999), still the most comprehensive text on directional statistics. Many of those developments have been stimulated by interesting applications in fields as diverse as astronomy, medicine, genetics, neurology, aeronautics, acoustics, image analysis, text mining, environmetrics, and machine learning. We begin by considering developments for the exploratory analysis of directional data before progressing to distributional models, general approaches to inference, hypothesis testing, regression, nonparametric curve estimation, methods for dimension reduction, classification and clustering, and the modelling of time series, spatial and spatio-temporal data. An overview of currently available software for analysing directional data is also provided, and potential future developments discussed.Comment: 61 page

A Robust Method for Speech Emotion Recognition Based on Infinite Student’s t

Speech emotion classification method, proposed in this paper, is based on Student’s t-mixture model with infinite component number (iSMM) and can directly conduct effective recognition for various kinds of speech emotion samples. Compared with the traditional GMM (Gaussian mixture model), speech emotion model based on Student’s t-mixture can effectively handle speech sample outliers that exist in the emotion feature space. Moreover, t-mixture model could keep robust to atypical emotion test data. In allusion to the high data complexity caused by high-dimensional space and the problem of insufficient training samples, a global latent space is joined to emotion model. Such an approach makes the number of components divided infinite and forms an iSMM emotion model, which can automatically determine the best number of components with lower complexity to complete various kinds of emotion characteristics data classification. Conducted over one spontaneous (FAU Aibo Emotion Corpus) and two acting (DES and EMO-DB) universal speech emotion databases which have high-dimensional feature samples and diversiform data distributions, the iSMM maintains better recognition performance than the comparisons. Thus, the effectiveness and generalization to the high-dimensional data and the outliers are verified. Hereby, the iSMM emotion model is verified as a robust method with the validity and generalization to outliers and high-dimensional emotion characters

Segmentation of brain MRI during early childhood

The objective of this thesis is the development of automatic methods to measure the changes in volume and growth of brain structures in prematurely born infants. Automatic tools for accurate tissue quantification from magnetic resonance images can provide means for understanding how the neurodevelopmental effects of the premature birth, such as cognitive, neurological or behavioural impairment, are related to underlying changes in brain anatomy. Understanding these changes forms a basis for development of suitable treatments to improve the outcomes of premature birth. In this thesis we focus on the segmentation of brain structures from magnetic resonance images during early childhood. Most of the current brain segmentation techniques have been focused on the segmentation of adult or neonatal brains. As a result of rapid development, the brain anatomy during early childhood differs from anatomy of both adult and neonatal brains and therefore requires adaptations of available techniques to produce good results. To address the issue of anatomical differences of the brain during early childhood compared to other age-groups, population-specific deformable and probabilistic atlases are introduced. A method for generation of population-specific prior information in form of a probabilistic atlas is proposed and used to enhance existing segmentation algorithms. The evaluation of registration-based and intensity-based approaches shows the techniques to be complementary in the quality of automatic segmentation in different parts of the brain. We propose a novel robust segmentation method combining the advantages of both approaches. The method is based on multiple label propagation using B-spline non-rigid registration followed by EM segmentation. Intensity inhomogeneity is a shading artefact resulting from the acquisition process, which significantly affects modern high resolution MR data acquired at higher magnetic field strengths. A novel template based method focused on correcting the intensity inhomogeneity in data acquired at higher magnetic field strengths is therefore proposed. The proposed segmentation method combined with proposed intensity inhomogeneity correction method offers a robust tool for quantification of volumes and growth of brain structures during early childhood. The tool have been applied to 67 T1-weigted images of subject at one and two years of age

Multimodal Interactive Transcription of Handwritten Text Images

En esta tesis se presenta un nuevo marco interactivo y multimodal para la transcripción de Documentos manuscritos. Esta aproximación, lejos de proporcionar la transcripción completa pretende asistir al experto en la dura tarea de transcribir. Hasta la fecha, los sistemas de reconocimiento de texto manuscrito disponibles no proporcionan transcripciones aceptables por los usuarios y, generalmente, se requiere la intervención del humano para corregir las transcripciones obtenidas. Estos sistemas han demostrado ser realmente útiles en aplicaciones restringidas y con vocabularios limitados (como es el caso del reconocimiento de direcciones postales o de cantidades numéricas en cheques bancarios), consiguiendo en este tipo de tareas resultados aceptables. Sin embargo, cuando se trabaja con documentos manuscritos sin ningún tipo de restricción (como documentos manuscritos antiguos o texto espontáneo), la tecnología actual solo consigue resultados inaceptables. El escenario interactivo estudiado en esta tesis permite una solución más efectiva. En este escenario, el sistema de reconocimiento y el usuario cooperan para generar la transcripción final de la imagen de texto. El sistema utiliza la imagen de texto y una parte de la transcripción previamente validada (prefijo) para proponer una posible continuación. Despues, el usuario encuentra y corrige el siguente error producido por el sistema, generando así un nuevo prefijo mas largo. Este nuevo prefijo, es utilizado por el sistema para sugerir una nueva hipótesis. La tecnología utilizada se basa en modelos ocultos de Markov y n-gramas. Estos modelos son utilizados aquí de la misma manera que en el reconocimiento automático del habla. Algunas modificaciones en la definición convencional de los n-gramas han sido necesarias para tener en cuenta la retroalimentación del usuario en este sistema.Romero Gómez, V. (2010). Multimodal Interactive Transcription of Handwritten Text Images [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/8541Palanci

Advanced Algorithms for 3D Medical Image Data Fusion in Specific Medical Problems

Fúze obrazu je dnes jednou z nejběžnějších avšak stále velmi diskutovanou oblastí v lékařském zobrazování a hraje důležitou roli ve všech oblastech lékařské péče jako je diagnóza, léčba a chirurgie. V této dizertační práci jsou představeny tři projekty, které jsou velmi úzce spojeny s oblastí fúze medicínských dat. První projekt pojednává o 3D CT subtrakční angiografii dolních končetin. V práci je využito kombinace kontrastních a nekontrastních dat pro získání kompletního cévního stromu. Druhý projekt se zabývá fúzí DTI a T1 váhovaných MRI dat mozku. Cílem tohoto projektu je zkombinovat stukturální a funkční informace, které umožňují zlepšit znalosti konektivity v mozkové tkáni. Třetí projekt se zabývá metastázemi v CT časových datech páteře. Tento projekt je zaměřen na studium vývoje metastáz uvnitř obratlů ve fúzované časové řadě snímků. Tato dizertační práce představuje novou metodologii pro klasifikaci těchto metastáz. Všechny projekty zmíněné v této dizertační práci byly řešeny v rámci pracovní skupiny zabývající se analýzou lékařských dat, kterou vedl pan Prof. Jiří Jan. Tato dizertační práce obsahuje registrační část prvního a klasifikační část třetího projektu. Druhý projekt je představen kompletně. Další část prvního a třetího projektu, obsahující specifické předzpracování dat, jsou obsaženy v disertační práci mého kolegy Ing. Romana Petera.Image fusion is one of today´s most common and still challenging tasks in medical imaging and it plays crucial role in all areas of medical care such as diagnosis, treatment and surgery. Three projects crucially dependent on image fusion are introduced in this thesis. The first project deals with the 3D CT subtraction angiography of lower limbs. It combines pre-contrast and contrast enhanced data to extract the blood vessel tree. The second project fuses the DTI and T1-weighted MRI brain data. The aim of this project is to combine the brain structural and functional information that purvey improved knowledge about intrinsic brain connectivity. The third project deals with the time series of CT spine data where the metastases occur. In this project the progression of metastases within the vertebrae is studied based on fusion of the successive elements of the image series. This thesis introduces new methodology of classifying metastatic tissue. All the projects mentioned in this thesis have been solved by the medical image analysis group led by Prof. Jiří Jan. This dissertation concerns primarily the registration part of the first project and the classification part of the third project. The second project is described completely. The other parts of the first and third project, including the specific preprocessing of the data, are introduced in detail in the dissertation thesis of my colleague Roman Peter, M.Sc.

Constrained clustering with a complex cluster structure

In this contribution we present a novel constrained clustering method, Constrained clustering with a complex cluster structure (C4s), which incorporates equivalence constraints, both positive and negative, as the background information. C4s is capable of discovering groups of arbitrary structure, e.g. with multi-modal distribution, since at the initial stage the equivalence classes of elements generated by the positive constraints are split into smaller parts. This provides a detailed description of elements, which are in positive equivalence relation. In order to enable an automatic detection of the number of groups, the cross-entropy clustering is applied for each partitioning process. Experiments show that the proposed method achieves significantly better results than previous constrained clustering approaches. The advantage of our algorithm increases when we are focusing on finding partitions with complex structure of clusters

Multidimensional image analysis of cardiac function in MRI

Cardiac morphology is a key indicator of cardiac health. Important metrics that are currently in clinical use are left-ventricle cardiac ejection fraction, cardiac muscle (myocardium) mass, myocardium thickness and myocardium thickening over the cardiac cycle. Advances in imaging technologies have led to an increase in temporal and spatial resolution. Such an increase in data presents a laborious task for medical practitioners to analyse. In this thesis, measurement of the cardiac left-ventricle function is achieved by developing novel methods for the automatic segmentation of the left-ventricle blood-pool and the left ventricle myocardium boundaries. A preliminary challenge faced in this task is the removal of noise from Magnetic Resonance Imaging (MRI) data, which is addressed by using advanced data filtering procedures. Two mechanisms for left-ventricle segmentation are employed. Firstly segmentation of the left ventricle blood-pool for the measurement of ejection fraction is undertaken in the signal intensity domain. Utilising the high discrimination between blood and tissue, a novel methodology based on a statistical partitioning method offers success in localising and segmenting the blood pool of the left ventricle. From this initialisation, the estimation of the outer wall (epi-cardium) of the left ventricle can be achieved using gradient information and prior knowledge. Secondly, a more involved method for extracting the myocardium of the leftventricle is developed, that can better perform segmentation in higher dimensions. Spatial information is incorporated in the segmentation by employing a gradient-based boundary evolution. A level-set scheme is implemented and a novel formulation for the extraction of the cardiac muscle is introduced. Two surfaces, representing the inner and the outer boundaries of the left-ventricle, are simultaneously evolved using a coupling function and supervised with a probabilistic model of expertly assisted manual segmentations

Visual Prototyping of Cloth

Realistic visualization of cloth has many applications in computer graphics. An ongoing research problem is how to best represent and capture appearance models of cloth, especially when considering computer aided design of cloth. Previous methods can be used to produce highly realistic images, however, possibilities for cloth-editing are either restricted or require the measurement of large material databases to capture all variations of cloth samples. We propose a pipeline for designing the appearance of cloth directly based on those elements that can be changed within the production process. These are optical properties of fibers, geometrical properties of yarns and compositional elements such as weave patterns. We introduce a geometric yarn model, integrating state-of-the-art textile research. We further present an approach to reverse engineer cloth and estimate parameters for a procedural cloth model from single images. This includes the automatic estimation of yarn paths, yarn widths, their variation and a weave pattern. We demonstrate that we are able to match the appearance of original cloth samples in an input photograph for several examples. Parameters of our model are fully editable, enabling intuitive appearance design. Unfortunately, such explicit fiber-based models can only be used to render small cloth samples, due to large storage requirements. Recently, bidirectional texture functions (BTFs) have become popular for efficient photo-realistic rendering of materials. We present a rendering approach combining the strength of a procedural model of micro-geometry with the efficiency of BTFs. We propose a method for the computation of synthetic BTFs using Monte Carlo path tracing of micro-geometry. We observe that BTFs usually consist of many similar apparent bidirectional reflectance distribution functions (ABRDFs). By exploiting structural self-similarity, we can reduce rendering times by one order of magnitude. This is done in a process we call non-local image reconstruction, which has been inspired by non-local means filtering. Our results indicate that synthesizing BTFs is highly practical and may currently only take a few minutes for small BTFs. We finally propose a novel and general approach to physically accurate rendering of large cloth samples. By using a statistical volumetric model, approximating the distribution of yarn fibers, a prohibitively costly, explicit geometric representation is avoided. As a result, accurate rendering of even large pieces of fabrics becomes practical without sacrificing much generality compared to fiber-based techniques