A Comparative Study of Different Blood Vessel Detection on Retinal Images

Detection of blood vessel plays an important stage in different medical areas, such as ophthalmology, oncology, neurosurgery, and laryngology. The significance of the vessel analysis was helped by the continuous overview in clinical studies of new medical technologies intended for improving the visualization of vessels. In this paper, several local segmentation techniques which include such as Vascular Tree Extraction, Tyler L. Coye and Line tracking, Kirsch’s Template and Fuzzy C Mean methods were studied. The main objective is to determine the best approaches in order to detect the blood vessel on the degraded retinal input image (DRIVE dataset). A few Image Quality Assessment (IQA) was obtained to prove the effectiveness of each detection methods. Overall, the result of sensitivity highest came from Kirsch Templates (96.928), while specificity from Fuzzy C means (77.573). However, in term of accuracy average, the Line Tracking method is more successful compared to the other methods

Automatic Blood Vessel Extraction of Fundus Images Employing Fuzzy Approach

Diabetic Retinopathy is a retinal vascular disease that is characterized by progressive deterioration of blood vessels in the retina and is distinguished by the appearance of different types of clinical lesions like microaneurysms, hemorrhages, exudates etc. Automated detection of the lesions plays significant role for early diagnosis by enabling medication for the treatment of severe eye diseases preventing visual loss. Extraction of blood vessels can facilitate ophthalmic services by automating computer aided screening of fundus images. This paper presents blood vessel extraction algorithms with ensemble of pre-processing and post-processing steps which enhance the image quality for better analysis of retinal images for automated detection. Extensive performance based evaluation of the proposed approaches is done over four databases on the basis of statistical parameters. Comparison of both blood vessel extraction techniques on different databases reveals that fuzzy based approach gives better results as compared to Kirsch’s based algorithm. The results obtained from this study reveal that 89% average accuracy is offered by the proposed MBVEKA and 98% for proposed BVEFA

Analysis of Retinal Image Data to Support Glaucoma Diagnosis

Fundus kamera je široce dostupné zobrazovací zařízení, které umožňuje relativně rychlé a nenákladné vyšetření zadního segmentu oka – sítnice. Z těchto důvodů se mnoho výzkumných pracovišť zaměřuje právě na vývoj automatických metod diagnostiky nemocí sítnice s využitím fundus fotografií. Tato dizertační práce analyzuje současný stav vědeckého poznání v oblasti diagnostiky glaukomu s využitím fundus kamery a navrhuje novou metodiku hodnocení vrstvy nervových vláken (VNV) na sítnici pomocí texturní analýzy. Spolu s touto metodikou je navržena metoda segmentace cévního řečiště sítnice, jakožto další hodnotný příspěvek k současnému stavu řešené problematiky. Segmentace cévního řečiště rovněž slouží jako nezbytný krok předcházející analýzu VNV. Vedle toho práce publikuje novou volně dostupnou databázi snímků sítnice se zlatými standardy pro účely hodnocení automatických metod segmentace cévního řečiště.Fundus camera is widely available imaging device enabling fast and cheap examination of the human retina. Hence, many researchers focus on development of automatic methods towards assessment of various retinal diseases via fundus images. This dissertation summarizes recent state-of-the-art in the field of glaucoma diagnosis using fundus camera and proposes a novel methodology for assessment of the retinal nerve fiber layer (RNFL) via texture analysis. Along with it, a method for the retinal blood vessel segmentation is introduced as an additional valuable contribution to the recent state-of-the-art in the field of retinal image processing. Segmentation of the blood vessels also serves as a necessary step preceding evaluation of the RNFL via the proposed methodology. In addition, a new publicly available high-resolution retinal image database with gold standard data is introduced as a novel opportunity for other researches to evaluate their segmentation algorithms.

Retinal vessel segmentation using textons

Segmenting vessels from retinal images, like segmentation in many other medical image domains, is a challenging task, as there is no unified way that can be adopted to extract the vessels accurately. However, it is the most critical stage in automatic assessment of various forms of diseases (e.g. Glaucoma, Age-related macular degeneration, diabetic retinopathy and cardiovascular diseases etc.). Our research aims to investigate retinal image segmentation approaches based on textons as they provide a compact description of texture that can be learnt from a training set. This thesis presents a brief review of those diseases and also includes their current situations, future trends and techniques used for their automatic diagnosis in routine clinical applications. The importance of retinal vessel segmentation is particularly emphasized in such applications. An extensive review of previous work on retinal vessel segmentation and salient texture analysis methods is presented. Five automatic retinal vessel segmentation methods are proposed in this thesis. The first method focuses on addressing the problem of removing pathological anomalies (Drusen, exudates) for retinal vessel segmentation, which have been identified by other researchers as a problem and a common source of error. The results show that the modified method shows some improvement compared to a previously published method. The second novel supervised segmentation method employs textons. We propose a new filter bank (MR11) that includes bar detectors for vascular feature extraction and other kernels to detect edges and photometric variations in the image. The k-means clustering algorithm is adopted for texton generation based on the vessel and non-vessel elements which are identified by ground truth. The third improved supervised method is developed based on the second one, in which textons are generated by k-means clustering and texton maps representing vessels are derived by back projecting pixel clusters onto hand labelled ground truth. A further step is implemented to ensure that the best combinations of textons are represented in the map and subsequently used to identify vessels in the test set. The experimental results on two benchmark datasets show that our proposed method performs well compared to other published work and the results of human experts. A further test of our system on an independent set of optical fundus images verified its consistent performance. The statistical analysis on experimental results also reveals that it is possible to train unified textons for retinal vessel segmentation. In the fourth method a novel scheme using Gabor filter bank for vessel feature extraction is proposed. The ii method is inspired by the human visual system. Machine learning is used to optimize the Gabor filter parameters. The experimental results demonstrate that our method significantly enhances the true positive rate while maintaining a level of specificity that is comparable with other approaches. Finally, we proposed a new unsupervised texton based retinal vessel segmentation method using derivative of SIFT and multi-scale Gabor filers. The lack of sufficient quantities of hand labelled ground truth and the high level of variability in ground truth labels amongst experts provides the motivation for this approach. The evaluation results reveal that our unsupervised segmentation method is comparable with the best other supervised methods and other best state of the art methods

Computerized Approaches for Retinal Microaneurysm Detection

The number of diabetic patients throughout the world is increasing with a very high rate. The patients suffering from long term diabetes have a very high risk of generating retinal disorder called Diabetic Retinopathy(DR). The disease is a complication of diabetes and may results in irreversible blindness to the patient. Early diagnosis and routine checkups by expert ophthalmologist possibly prevent the vision loss. But the number of people to be screen exceeds the number of experts, especially in rural areas. Thus the computerized screening systems are needed which will accurately screen the large amount of population and identify healthy and diseased people. Thus the workload on experts is reduced significantly. Microaneurysms(MA) are first recognizable signs of DR. Thus early detection of DR requires accurate detection of Microaneurysms. Computerized diagnosis insures reliable and accurate detection of MA's. The paper overviews the approaches for computerized detection of retinal Microaneurysms

Joint segmentation and classification of retinal arteries/veins from fundus images

Objective Automatic artery/vein (A/V) segmentation from fundus images is required to track blood vessel changes occurring with many pathologies including retinopathy and cardiovascular pathologies. One of the clinical measures that quantifies vessel changes is the arterio-venous ratio (AVR) which represents the ratio between artery and vein diameters. This measure significantly depends on the accuracy of vessel segmentation and classification into arteries and veins. This paper proposes a fast, novel method for semantic A/V segmentation combining deep learning and graph propagation. Methods A convolutional neural network (CNN) is proposed to jointly segment and classify vessels into arteries and veins. The initial CNN labeling is propagated through a graph representation of the retinal vasculature, whose nodes are defined as the vessel branches and edges are weighted by the cost of linking pairs of branches. To efficiently propagate the labels, the graph is simplified into its minimum spanning tree. Results The method achieves an accuracy of 94.8% for vessels segmentation. The A/V classification achieves a specificity of 92.9% with a sensitivity of 93.7% on the CT-DRIVE database compared to the state-of-the-art-specificity and sensitivity, both of 91.7%. Conclusion The results show that our method outperforms the leading previous works on a public dataset for A/V classification and is by far the fastest. Significance The proposed global AVR calculated on the whole fundus image using our automatic A/V segmentation method can better track vessel changes associated to diabetic retinopathy than the standard local AVR calculated only around the optic disc.Comment: Preprint accepted in Artificial Intelligence in Medicin

A Review: Person Identification using Retinal Fundus Images

In this paper a review on biometric person identification has been discussed using features from retinal fundus image. Retina recognition is claimed to be the best person identification method among the biometric recognition systems as the retina is practically impossible to forge. It is found to be most stable, reliable and most secure among all other biometric systems. Retina inherits the property of uniqueness and stability. The features used in the recognition process are either blood vessel features or non-blood vessel features. But the vascular pattern is the most prominent feature utilized by most of the researchers for retina based person identification. Processes involved in this authentication system include pre-processing, feature extraction and feature matching. Bifurcation and crossover points are widely used features among the blood vessel features. Non-blood vessel features include luminance, contrast, and corner points etc. This paper summarizes and compares the different retina based authentication system. Researchers have used publicly available databases such as DRIVE, STARE, VARIA, RIDB, ARIA, AFIO, DRIDB, and SiMES for testing their methods. Various quantitative measures such as accuracy, recognition rate, false rejection rate, false acceptance rate, and equal error rate are used to evaluate the performance of different algorithms. DRIVE database provides 100\% recognition for most of the methods. Rest of the database the accuracy of recognition is more than 90\%

A Rule Based Segmentation Approaches to Extract Retinal Blood Vessels in Fundus Image

The physiological structures of the retinal blood vessel are one of the key features that visible in the retinal images and contain the information associate with the anatomical abnormalities. It is accepted all over the world to judge the cardiovascular and retinal disease. To avoid the risk of visual impairment, appropriate vessel segmentation is mandatory. Here has proposed a segmentation algorithm that efficiently extracts the blood vessels from the retinal fundus image. The proposed segmentation algorithm is performed Lab and Principle Component (PC) based gray level conversion, Contrast Limited Adaptive Histogram Equalization (CLAHE), morphological operations, Local Property-Based Pixel Correction (LPBPC). For appropriate detection proposed vessels correction algorithm LPBPC that check the feature of the vessels and remove the wrong vessel detection. To measure the appropriateness of the proposed algorithm, the experimental results are compared with the corresponding ground truth images. The experimental results have shown that the proposed blood vessel algorithm is more accurate than the existing algorithms