Safety and Ergonomics of Iron Casts Manufacturing

The article presents the issues of production analysis of iron casts manufacturing using automated foundry lines. To streamline the production fl ow, it was proposed to change the location of workstations related to grinding, control and machining of casts. Within the process of constant improvement of manufacturing processes, the aspect of work ergonomics at a workstation was taken into account. As a result of the undertaken actions, some activities without added value were eliminated, effi ciency was increased and prime costs of manufacturing casts with regard to fi nishing treatment were lowered

High-Level Object Oriented Genetic Programming in Logistic Warehouse Optimization

Disertační práce je zaměřena na optimalizaci průběhu pracovních operací v logistických skladech a distribučních centrech. Hlavním cílem je optimalizovat procesy plánování, rozvrhování a odbavování. Jelikož jde o problém patřící do třídy složitosti NP-težký, je výpočetně velmi náročné nalézt optimální řešení. Motivací pro řešení této práce je vyplnění pomyslné mezery mezi metodami zkoumanými na vědecké a akademické půdě a metodami používanými v produkčních komerčních prostředích. Jádro optimalizačního algoritmu je založeno na základě genetického programování řízeného bezkontextovou gramatikou. Hlavním přínosem této práce je a) navrhnout nový optimalizační algoritmus, který respektuje následující optimalizační podmínky: celkový čas zpracování, využití zdrojů, a zahlcení skladových uliček, které může nastat během zpracování úkolů, b) analyzovat historická data z provozu skladu a vyvinout sadu testovacích příkladů, které mohou sloužit jako referenční výsledky pro další výzkum, a dále c) pokusit se předčit stanovené referenční výsledky dosažené kvalifikovaným a trénovaným operačním manažerem jednoho z největších skladů ve střední Evropě.This work is focused on the work-flow optimization in logistic warehouses and distribution centers. The main aim is to optimize process planning, scheduling, and dispatching. The problem is quite accented in recent years. The problem is of NP hard class of problems and where is very computationally demanding to find an optimal solution. The main motivation for solving this problem is to fill the gap between the new optimization methods developed by researchers in academic world and the methods used in business world. The core of the optimization algorithm is built on the genetic programming driven by the context-free grammar. The main contribution of the thesis is a) to propose a new optimization algorithm which respects the makespan, the utilization, and the congestions of aisles which may occur, b) to analyze historical operational data from warehouse and to develop the set of benchmarks which could serve as the reference baseline results for further research, and c) to try outperform the baseline results set by the skilled and trained operational manager of the one of the biggest warehouses in the middle Europe.

Intelligent Simulation Modeling of a Flexible Manufacturing System with Automated Guided Vehicles

Although simulation is a very flexible and cost effective problem solving technique, it has been traditionally limited to building models which are merely descriptive of the system under study. Relatively new approaches combine improvement heuristics and artificial intelligence with simulation to provide prescriptive power in simulation modeling. This study demonstrates the synergy obtained by bringing together the "learning automata theory" and simulation analysis. Intelligent objects are embedded in the simulation model of a Flexible Manufacturing System (FMS), in which Automated Guided Vehicles (AGVs) serve as the material handling system between four unique workcenters. The objective of the study is to find satisfactory AGV routing patterns along available paths to minimize the mean time spent by different kinds of parts in the system. System parameters such as different part routing and processing time requirements, arrivals distribution, number of palettes, available paths between workcenters, number and speed of AGVs can be defined by the user. The network of learning automata acts as the decision maker driving the simulation, and the FMS model acts as the training environment for the automata network; providing realistic, yet cost-effective and risk-free feedback. Object oriented design and implementation of the simulation model with a process oriented world view, graphical animation and visually interactive simulation (using GUI objects such as windows, menus, dialog boxes; mouse sensitive dynamic automaton trace charts and dynamic graphical statistical monitoring) are other issues dealt with in the study

Process assessment for the extended enterprise during early product development using novel computational techniques

Manufacturing practices have evolved over the last quarter of a century in the light of changes to manufacturing technology and demand. To sustain this growth companies are increasingly focused on better design and quicker time to market, to stay one step ahead of the competition. Expanding technology capabilities have included microcomputers and telecommunications. In particular the Internet has allowed businesses to trade with an extended customer base, resulting in a greater demand and perpetuating the cycle. To mirror this statement, businesses are looking increasingly far and wide for suitable suppliers. This work identifies a need in the market for an Internet based supplier selection function, during early product development. The development of this work differs significantly from other process selection methods by the use of the Internet to link companies. It has advantages for product development relating to the scope of the opportunities, diversity of possible manufacturing operations and rapid assessment of processes. In particular the system can be broken down into two main functions. Process Selection (PS) and Factory Selection (FS). The PS method presented enables many processes to be modelled, in multiple organisations for a single product. The Internet is used to gain access to supplier facilities by adopting the same principles as on-line banking, or shopping, for data input and access. The results of these assessments are retained by the system for later analysis. The FS method utilises this data to model and compare supplier attributes, allowing the user to manipulate the data to fit their requirements. Testing of the system has proved encouraging for many operations, including Injection Moulding and CNC Machining. It can be concluded that the identification of manufacturing operations outside the remit of companies' normal scope will create further opportunities for supplier integration

From production to patient: challenges and approaches for delivering cell therapies.

The cell therapy industry is rapidly growing with several new products approved for clinical use over the past few years and many more currently in clinical trials. Nonetheless, a number of challenges remain in getting cell therapies to the market and into routine use. For instance, cell therapy bioprocesses still need to be optimised, but if these therapies are to be widely adopted there must also be clear routes for their delivery from the site of manufacture to the clinic and the patients. This review explores the currently available routes, the factors that need to be taken into consideration when choosing a route and the challenges that remain with respect to cell therapy logistics

Guidelines for the use of cell lines in biomedical research

Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture. Many of these problems are avoidable with the necessary foresight, and these Guidelines have been prepared to provide those new to the field and others engaged in teaching and instruction with the information necessary to increase their awareness of the problems and to enable them to deal with them effectively. The Guidelines cover areas such as development, acquisition, authentication, cryopreservation, transfer of cell lines between laboratories, microbial contamination, characterisation, instability and misidentification. Advice is also given on complying with current legal and ethical requirements when deriving cell lines from human and animal tissues, the selection and maintenance of equipment and how to deal with problems that may arise

Automation of garment assembly processes

Robotic automation in apparel manufacturing is reviewed and investigated. Gripper design for separation and de-stacking of batch cut fabric components is identified as an important factor in implementing such automation and a study of existing gripper mechanisms is presented. New de-stacking gripper designs and processes are described together with experimental results. Single fabric component handling, alignment and registration techniques are investigated. Some of these techniques are integrated within a demonstrator robotic garment assembly cell automating the common edge binding process. Performance results are reported

Hybrid optical and magnetic manipulation of microrobots

Microrobotic systems have the potential to provide precise manipulation on cellular level for diagnostics, drug delivery and surgical interventions. These systems vary from tethered to untethered microrobots with sizes below a micrometer to a few microns. However, their main disadvantage is that they do not have the same capabilities in terms of degrees-of-freedom, sensing and control as macroscale robotic systems. In particular, their lack of on-board sensing for pose or force feedback, their control methods and interface for automated or manual user control are limited as well as their geometry has few degrees-of-freedom making three-dimensional manipulation more challenging. This PhD project is on the development of a micromanipulation framework that can be used for single cell analysis using the Optical Tweezers as well as a combination of optical trapping and magnetic actuation for recon gurable microassembly. The focus is on untethered microrobots with sizes up to a few tens of microns that can be used in enclosed environments for ex vivo and in vitro medical applications. The work presented investigates the following aspects of microrobots for single cell analysis: i) The microfabrication procedure and design considerations that are taken into account in order to fabricate components for three-dimensional micromanipulation and microassembly, ii) vision-based methods to provide 6-degree-offreedom position and orientation feedback which is essential for closed-loop control, iii) manual and shared control manipulation methodologies that take into account the user input for multiple microrobot or three-dimensional microstructure manipulation and iv) a methodology for recon gurable microassembly combining the Optical Tweezers with magnetic actuation into a hybrid method of actuation for microassembly.Open Acces