Cancer Detection Using Neuro Fuzzy Classifier in CT Images

In this study, we have implemented an adaptive neuro fuzzy inference system (ANFIS) for detection of mass in CT images for early diagnosis of lung cancer. After completion of preprocessing and segmentation process four features have been extracted from images and given to ANFIS classifier as an input. The fuzzy system detects the severity of the lung nodules depends on IF-THEN rules. Feature based data set has been created with five fuzzy membership functions of each input. The proposed model is applied on more than 150 images and the computer added diagnosis (CAD) system achieved sensitivity of 97.27% and specificity of 95% with accuracy of 96.66%

Lung Nodule Detection in CT Images using Neuro Fuzzy Classifier

Automated lung cancer detection using computer aided diagnosis (CAD) is an important area in clinical applications. As the manual nodule detection is very time consuming and costly so computerized systems can be helpful for this purpose. In this paper, we propose a computerized system for lung nodule detection in CT scan images. The automated system consists of two stages i.e. lung segmentation and enhancement, feature extraction and classification. The segmentation process will result in separating lung tissue from rest of the image, and only the lung tissues under examination are considered as candidate regions for detecting malignant nodules in lung portion. A feature vector for possible abnormal regions is calculated and regions are classified using neuro fuzzy classifier. It is a fully automatic system that does not require any manual intervention and experimental results show the validity of our system

A novel CAD system to automatically detect cancerous lung nodules using wavelet transform and SVM

A novel cancerous nodules detection algorithm for computed tomography images (CT-images) is presented in this paper. CT-images are large size images with high resolution. In some cases, number of cancerous lung nodule lesions may missed by the radiologist due to fatigue. A CAD system that is proposed in this paper can help the radiologist in detecting cancerous nodules in CT- images. The proposed algorithm is divided to four stages. In the first stage, an enhancement algorithm is implement to highlight the suspicious regions. Then in the second stage, the region of interest will be detected. The adaptive SVM and wavelet transform techniques are used to reduce the detected false positive regions. This algorithm is evaluated using 60 cases (normal and cancerous cases), and it shows a high sensitivity in detecting the cancerous lung nodules with TP ration 94.5% and with FP ratio 7 cluster/image

Cancerous lung nodule detection in computed tomography images

Diagnosis the computed tomography images (CT-images) is one of the images that may take a lot of time in diagnosis by the radiologist and may miss some of cancerous nodules in these images. Therefore, in this paper a new novel enhancement and detection cancerous nodule algorithm is proposed to diagnose a CT-images. The novel algorithm is divided into three main stages. In first stage, suspicious regions are enhanced using modified LoG algorithm. Then in stage two, a potential cancerous nodule was detected based on visual appearance in lung. Finally, five texture features analysis algorithm is implemented to reduce number of detected FP regions. This algorithm is evaluated using 60 cases (normal and cancerous cases), and it shows a high sensitivity in detecting the cancerous lung nodules with TP ration 97% and with FP ratio 25 cluster/image

Analysis of Various Classification Techniques for Computer Aided Detection System of Pulmonary Nodules in CT

Lung cancer is the leading cause of cancer death in the United States. It usually exhibits its presence with the formation of pulmonary nodules. Nodules are round or oval-shaped growth present in the lung. Computed Tomography (CT) scans are used by radiologists to detect such nodules. Computer Aided Detection (CAD) of such nodules would aid in providing a second opinion to the radiologists and would be of valuable help in lung cancer screening. In this research, we study various feature selection methods for the CAD system framework proposed in FlyerScan. Algorithmic steps of FlyerScan include (i) local contrast enhancement (ii) automated anatomical segmentation (iii) detection of potential nodule candidates (iv) feature computation & selection and (v) candidate classification. In this paper, we study the performance of the FlyerScan by implementing various classification methods such as linear, quadratic and Fischer linear discriminant classifier. This algorithm is implemented using a publicly available Lung Image Database Consortium – Image Database Resource Initiative (LIDC-IDRI) dataset. 107 cases from LIDC-IDRI are handpicked in particular for this paper and performance of the CAD system is studied based on 5 example cases of Automatic Nodule Detection (ANODE09) database. This research will aid in improving the nodule detection rate in CT scans, thereby enhancing a patient’s chance of survival

Automatic lung nodule detection from chest CT data using geometrical features: initial results

In this paper, a complete system for automatic lung nodule detection from Chest CT data is proposed. The proposed system includes the methods of lung segmentation and nodule detection from CT data. The algorithm for lung segmentation consists ofsurrounding air voxel removal, body fat/tissue identification, trachea detection, and pulmonary vessels segmentation. The nodule detection algorithm comprises of candidate surface generation, geometrical feature generation and classification. The proposed system shows 88.2% sensitivity for nodule >=3mm with 8.91 false positive per dataset

Nodule Detection in a Lung Region that's Segmented with Using Genetic Cellular Neural Networks and 3D Template Matching with Fuzzy Rule Based Thresholding

Objective: The purpose of this study was to develop a new method for automated lung nodule detection in serial section CT images with using the characteristics of the 3D appearance of the nodules that distinguish themselves from the vessels

A Method of Using Information Entropy of an Image as an Effective Feature for Computer-Aided Diagnostic Applications

Abstract Computer-aided detection and diagnosis (CAD) systems are increasingly being used as an aid by clinicians for detection and interpretation of diseases. In general, a CAD system employs a classifier to detect or distinguish between abnormal and normal tissues on images. In the phase of classification, a set of image features and/or texture features extracted from the images are commonly used. In this article, we investigated the characteristic of the output entropy of an image and demonstrated the usefulness of the output entropy acting as a texture feature in CAD systems. In order to validate the effectiveness and superiority of the output-entropy-based texture feature, two well-known texture features, i.e., mean and standard deviation were used for comparison. The database used in this study comprised 50 CT images obtained from 10 patients with pulmonary nodules, and 50 CT images obtained from 5 normal subjects. We used a support vector machine for classification. A leave-one-out method was employed for training and classification. Three combinations of texture features, i.e., mean and entropy, standard deviation and entropy, and standard deviation and mean were used as the inputs to the classifier. Three different regions of interest (ROI) sizes, i.e., 11 × 11, 9 × 9 and 7 × 7 pixels from the database were selected for computation of the feature values. Our experimental results show that the combination of entropy and standard deviation is significantly better than both the combination of mean and entropy and that of standard deviation and mean in the case of the ROI size of 11 × 11 pixels (p < 0.05). These results suggest that information entropy of an image can be used as an effective feature for CAD applications. E. Matsuyama et al. 31

Eigenspace Template Matching for Detection of Lacunar Infarcts on MR Images

Abstract Detection of lacunar infarcts is important because their presence indicates an increased risk of severe cerebral infarction. However, accurate identification is often hindered by the difficulty in distinguishing between lacunar infarcts and enlarged Virchow-Robin spaces. Therefore, we developed a computer-aided detection (CAD) scheme for the detection of lacunar infarcts. Although our previous CAD method indicated a sensitivity of 96.8 % with 0.71 false positives (FPs) per slice, further reduction of FPs remained an issue for the clinical application. Thus, the purpose of this study is to improve our CAD scheme by using template matching in the eigenspace. Conventional template matching is useful for the reduction of FPs, but it has the following two pitfalls: (1) It needs to maintain a large number of templates to improve the detection performance, and (2) calculation of the crosscorrelation coefficient with these templates is time consuming. To solve these problems, we used template matching in the lower dimension space made by a principal component analysis. Our database comprised 1,143 T 1 -and T 2 -weighted images obtained from 132 patients. The proposed method was evaluated by using twofold cross-validation. By using this method, 34.1 % of FPs was eliminated compared with our previous method. The final performance indicated that the sensitivity of the detection of lacunar infarcts was 96.8 % with 0.47 FPs per slice. Therefore, the modified CAD scheme could improve FP rate without a significant reduction in the true positive rate