On the Real-Time Performance, Robustness and Accuracy of Medical Image Non-Rigid Registration

Three critical issues about medical image non-rigid registration are performance, robustness and accuracy. A registration method, which is capable of responding timely with an accurate alignment, robust against the variation of the image intensity and the missing data, is desirable for its clinical use. This work addresses all three of these issues. Unacceptable execution time of Non-rigid registration (NRR) often presents a major obstacle to its routine clinical use. We present a hybrid data partitioning method to parallelize a NRR method on a cooperative architecture, which enables us to get closer to the goal: accelerating using architecture rather than designing a parallel algorithm from scratch. to further accelerate the performance for the GPU part, a GPU optimization tool is provided to automatically optimize GPU execution configuration.;Missing data and variation of the intensity are two severe challenges for the robustness of the registration method. A novel point-based NRR method is presented to resolve mapping function (deformation field) with the point correspondence missing. The novelty of this method lies in incorporating a finite element biomechanical model into an Expectation and Maximization (EM) framework to resolve the correspondence and mapping function simultaneously. This method is extended to deal with the deformation induced by tumor resection, which imposes another challenge, i.e. incomplete intra-operative MRI. The registration is formulated as a three variable (Correspondence, Deformation Field, and Resection Region) functional minimization problem and resolved by a Nested Expectation and Maximization framework. The experimental results show the effectiveness of this method in correcting the deformation in the vicinity of the tumor. to deal with the variation of the intensity, two different methods are developed depending on the specific application. For the mono-modality registration on delayed enhanced cardiac MRI and cine MRI, a hybrid registration method is designed by unifying both intensity- and feature point-based metrics into one cost function. The experiment on the moving propagation of suspicious myocardial infarction shows effectiveness of this hybrid method. For the multi-modality registration on MRI and CT, a Mutual Information (MI)-based NRR is developed by modeling the underlying deformation as a Free-Form Deformation (FFD). MI is sensitive to the variation of the intensity due to equidistant bins. We overcome this disadvantage by designing a Top-to-Down K-means clustering method to naturally group similar intensities into one bin. The experiment shows this method can increase the accuracy of the MI-based registration.;In image registration, a finite element biomechanical model is usually employed to simulate the underlying movement of the soft tissue. We develop a multi-tissue mesh generation method to build a heterogeneous biomechanical model to realistically simulate the underlying movement of the brain. We focus on the following four critical mesh properties: tissue-dependent resolution, fidelity to tissue boundaries, smoothness of mesh surfaces, and element quality. Each mesh property can be controlled on a tissue level. The experiments on comparing the homogeneous model with the heterogeneous model demonstrate the effectiveness of the heterogeneous model in improving the registration accuracy

Adaptive Methods for Point Cloud and Mesh Processing

Point clouds and 3D meshes are widely used in numerous applications ranging from games to virtual reality to autonomous vehicles. This dissertation proposes several approaches for noise removal and calibration of noisy point cloud data and 3D mesh sharpening methods. Order statistic filters have been proven to be very successful in image processing and other domains as well. Different variations of order statistics filters originally proposed for image processing are extended to point cloud filtering in this dissertation. A brand-new adaptive vector median is proposed in this dissertation for removing noise and outliers from noisy point cloud data. The major contributions of this research lie in four aspects: 1) Four order statistic algorithms are extended, and one adaptive filtering method is proposed for the noisy point cloud with improved results such as preserving significant features. These methods are applied to standard models as well as synthetic models, and real scenes, 2) A hardware acceleration of the proposed method using Microsoft parallel pattern library for filtering point clouds is implemented using multicore processors, 3) A new method for aerial LIDAR data filtering is proposed. The objective is to develop a method to enable automatic extraction of ground points from aerial LIDAR data with minimal human intervention, and 4) A novel method for mesh color sharpening using the discrete Laplace-Beltrami operator is proposed. Median and order statistics-based filters are widely used in signal processing and image processing because they can easily remove outlier noise and preserve important features. This dissertation demonstrates a wide range of results with median filter, vector median filter, fuzzy vector median filter, adaptive mean, adaptive median, and adaptive vector median filter on point cloud data. The experiments show that large-scale noise is removed while preserving important features of the point cloud with reasonable computation time. Quantitative criteria (e.g., complexity, Hausdorff distance, and the root mean squared error (RMSE)), as well as qualitative criteria (e.g., the perceived visual quality of the processed point cloud), are employed to assess the performance of the filters in various cases corrupted by different noisy models. The adaptive vector median is further optimized for denoising or ground filtering aerial LIDAR data point cloud. The adaptive vector median is also accelerated on multi-core CPUs using Microsoft Parallel Patterns Library. In addition, this dissertation presents a new method for mesh color sharpening using the discrete Laplace-Beltrami operator, which is an approximation of second order derivatives on irregular 3D meshes. The one-ring neighborhood is utilized to compute the Laplace-Beltrami operator. The color for each vertex is updated by adding the Laplace-Beltrami operator of the vertex color weighted by a factor to its original value. Different discretizations of the Laplace-Beltrami operator have been proposed for geometrical processing of 3D meshes. This work utilizes several discretizations of the Laplace-Beltrami operator for sharpening 3D mesh colors and compares their performance. Experimental results demonstrated the effectiveness of the proposed algorithms

Learning-based run-time power and energy management of multi/many-core systems: current and future trends

Multi/Many-core systems are prevalent in several application domains targeting different scales of computing such as embedded and cloud computing. These systems are able to fulfil the everincreasing performance requirements by exploiting their parallel processing capabilities. However, effective power/energy management is required during system operations due to several reasons such as to increase the operational time of battery operated systems, reduce the energy cost of datacenters, and improve thermal efficiency and reliability. This article provides an extensive survey of learning-based run-time power/energy management approaches. The survey includes a taxonomy of the learning-based approaches. These approaches perform design-time and/or run-time power/energy management by employing some learning principles such as reinforcement learning. The survey also highlights the trends followed by the learning-based run-time power management approaches, their upcoming trends and open research challenges

System software techniques to enhance reliability of modern platforms

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Neuromorphic Learning Systems for Supervised and Unsupervised Applications

The advancements in high performance computing (HPC) have enabled the large-scale implementation of neuromorphic learning models and pushed the research on computational intelligence into a new era. Those bio-inspired models are constructed on top of unified building blocks, i.e. neurons, and have revealed potentials for learning of complex information. Two major challenges remain in neuromorphic computing. Firstly, sophisticated structuring methods are needed to determine the connectivity of the neurons in order to model various problems accurately. Secondly, the models need to adapt to non-traditional architectures for improved computation speed and energy efficiency. In this thesis, we address these two problems and apply our techniques to different cognitive applications. This thesis first presents the self-structured confabulation network for anomaly detection. Among the machine learning applications, unsupervised detection of the anomalous streams is especially challenging because it requires both detection accuracy and real-time performance. Designing a computing framework that harnesses the growing computing power of the multicore systems while maintaining high sensitivity and specificity to the anomalies is an urgent research need. We present AnRAD (Anomaly Recognition And Detection), a bio-inspired detection framework that performs probabilistic inferences. We leverage the mutual information between the features and develop a self-structuring procedure that learns a succinct confabulation network from the unlabeled data. This network is capable of fast incremental learning, which continuously refines the knowledge base from the data streams. Compared to several existing anomaly detection methods, the proposed approach provides competitive detection accuracy as well as the insight to reason the decision making. Furthermore, we exploit the massive parallel structure of the AnRAD framework. Our implementation of the recall algorithms on the graphic processing unit (GPU) and the Xeon Phi co-processor both obtain substantial speedups over the sequential implementation on general-purpose microprocessor (GPP). The implementation enables real-time service to concurrent data streams with diversified contexts, and can be applied to large problems with multiple local patterns. Experimental results demonstrate high computing performance and memory efficiency. For vehicle abnormal behavior detection, the framework is able to monitor up to 16000 vehicles and their interactions in real-time with a single commodity co-processor, and uses less than 0.2ms for each testing subject. While adapting our streaming anomaly detection model to mobile devices or unmanned systems, the key challenge is to deliver required performance under the stringent power constraint. To address the paradox between performance and power consumption, brain-inspired hardware, such as the IBM Neurosynaptic System, has been developed to enable low power implementation of neural models. As a follow-up to the AnRAD framework, we proposed to port the detection network to the TrueNorth architecture. Implementing inference based anomaly detection on a neurosynaptic processor is not straightforward due to hardware limitations. A design flow and the supporting component library are developed to flexibly map the learned detection networks to the neurosynaptic cores. Instead of the popular rate code, burst code is adopted in the design, which represents numerical value using the phase of a burst of spike trains. This does not only reduce the hardware complexity, but also increases the result\u27s accuracy. A Corelet library, NeoInfer-TN, is implemented for basic operations in burst code and two-phase pipelines are constructed based on the library components. The design can be configured for different tradeoffs between detection accuracy, hardware resource consumptions, throughput and energy. We evaluate the system using network intrusion detection data streams. The results show higher detection rate than some conventional approaches and real-time performance, with only 50mW power consumption. Overall, it achieves 10^8 operations per Joule. In addition to the modeling and implementation of unsupervised anomaly detection, we also investigate a supervised learning model based on neural networks and deep fragment embedding and apply it to text-image retrieval. The study aims at bridging the gap between image and natural language. It continues to improve the bidirectional retrieval performance across the modalities. Unlike existing works that target at single sentence densely describing the image objects, we elevate the topic to associating deep image representations with noisy texts that are only loosely correlated. Based on text-image fragment embedding, our model employs a sequential configuration, connects two embedding stages together. The first stage learns the relevancy of the text fragments, and the second stage uses the filtered output from the first one to improve the matching results. The model also integrates multiple convolutional neural networks (CNN) to construct the image fragments, in which rich context information such as human faces can be extracted to increase the alignment accuracy. The proposed method is evaluated with both synthetic dataset and real-world dataset collected from picture news website. The results show up to 50% ranking performance improvement over the comparison models

Approximate Computing Survey, Part II: Application-Specific & Architectural Approximation Techniques and Applications

The challenging deployment of compute-intensive applications from domains such Artificial Intelligence (AI) and Digital Signal Processing (DSP), forces the community of computing systems to explore new design approaches. Approximate Computing appears as an emerging solution, allowing to tune the quality of results in the design of a system in order to improve the energy efficiency and/or performance. This radical paradigm shift has attracted interest from both academia and industry, resulting in significant research on approximation techniques and methodologies at different design layers (from system down to integrated circuits). Motivated by the wide appeal of Approximate Computing over the last 10 years, we conduct a two-part survey to cover key aspects (e.g., terminology and applications) and review the state-of-the art approximation techniques from all layers of the traditional computing stack. In Part II of our survey, we classify and present the technical details of application-specific and architectural approximation techniques, which both target the design of resource-efficient processors/accelerators & systems. Moreover, we present a detailed analysis of the application spectrum of Approximate Computing and discuss open challenges and future directions.Comment: Under Review at ACM Computing Survey

Secure and dependable cyber-physical system architectures

The increased computational power and connectivity in modern Cyber-Physical Systems (CPS) inevitably introduce more security vulnerabilities. The concern about CPS security is growing especially because a successful attack on safety-critical CPS (e.g., avionics, automobile, smart grid, etc.) can result in the safety of such systems being compromised, leading to disastrous effects, from loss of human life to damages to the environment as well as critical infrastructure. CPS poses unique security challenges due to its stringent design and implementation requirements. This dissertation explores the structural differences of CPS compared to the general-purpose systems and utilizes the intrinsic characteristics of CPS as an asymmetric advantage to thwart and detect security attacks to safety-critical CPS. The dissertation presents analytic techniques and system design principles to enhance the security and dependability of CPS, with particular focus on (a) modeling and reasoning about the logical and physical behaviors of CPS and (b) architectural and operating-system supports for trusted, efficient run-time monitoring as well as attack-resiliency