High-performance wireless power and data transfer interface for implantable medical devices

D’importants progès ont été réalisés dans le développement des systèmes biomédicaux implantables grâce aux dernières avancées de la microélectronique et des technologies sans fil. Néanmoins, ces appareils restent difficiles à commercialier. Cette situation est due particulièrement à un manque de stratégies de design capable supporter les fonctionnalités exigées, aux limites de miniaturisation, ainsi qu’au manque d’interface sans fil à haut débit fiable et faible puissance capable de connecter les implants et les périphériques externes. Le nombre de sites de stimulation et/ou d’électrodes d’enregistrement retrouvés dans les dernières interfaces cerveau-ordinateur (IMC) ne cesse de croître afin d’augmenter la précision de contrôle, et d’améliorer notre compréhension des fonctions cérébrales. Ce nombre est appelé à atteindre un millier de site à court terme, ce qui exige des débits de données atteingnant facilement les 500 Mbps. Ceci étant dit, ces travaux visent à élaborer de nouvelles stratégies innovantes de conception de dispositifs biomédicaux implantables afin de repousser les limites mentionnées ci-dessus. On présente de nouvelles techniques faible puissance beaucoup plus performantes pour le transfert d’énergie et de données sans fil à haut débit ainsi que l’analyse et la réalisation de ces dernières grâce à des prototypes microélectroniques CMOS. Dans un premier temps, ces travaux exposent notre nouvelle structure multibobine inductive à résonance présentant une puissance sans fil distribuée uniformément pour alimenter des systèmes miniatures d’étude du cerveaux avec des models animaux en ilberté ainsi que des dispositifs médicaux implantbles sans fil qui se caractérisent par une capacité de positionnement libre. La structure propose un lien de résonance multibobines inductive, dont le résonateur principal est constitué d’une multitude de résonateurs identiques disposés dans une matrice de bobines carrées. Ces dernières sont connectées en parallèle afin de réaliser des surfaces de puissance (2D) ainsi qu’une chambre d’alimentation (3D). La chambre proposée utilise deux matrices de résonateurs de base, mises face à face et connectés en parallèle afin d’obtenir une distribution d’énergie uniforme en 3D. Chaque surface comprend neuf bobines superposées, connectées en parallèle et réailsées sur une carte de circuit imprimé deux couches FR4. La chambre dispose d’un mécanisme naturel de localisation de puissance qui facilite sa mise en oeuvre et son fonctionnement. En procédant ainsi, nous évitons la nécessité d’une détection active de l’emplacement de la charge et le contrôle d’alimentation. Notre approche permet à cette surface d’alimentation unique de fournir une efficacité de transfert de puissance (PTE) de 69% et une puissance délivrée à la charge (PDL) de 120 mW, pour une distance de séparation de 4 cm, tandis que le prototype de chambre complet fournit un PTE uniforme de 59% et un PDL de 100 mW en 3D, partout à l’intérieur de la chambre avec un volume de chambre de 27 × 27 × 16 cm3. Une étape critique avant d’utiliser un dispositif implantable chez les humains consiste à vérifier ses fonctionnalités sur des sujets animaux. Par conséquent, la chambre d’énergie sans fil conçue sera utilisée afin de caractériser les performances d’ une interface sans fil de transmisison de données dans un environnement réaliste in vivo avec positionement libre. Un émetteur-récepteur full-duplex (FDT) entièrement intégré qui se caractérise par sa faible puissance est conçu pour réaliser une interfaces bi-directionnelles (stimulation et enregistrement) avec des débits asymétriques: des taux de tramnsmission plus élevés sont nécessaires pour l’enregistrement électrophysiologique multicanal (signaux de liaison montante) alors que les taux moins élevés sont utilisés pour la stimulation (les signaux de liaison descendante). L’émetteur (TX) et le récepteur (RX) se partagent une seule antenne afin de réduire la taille de l’implant. L’émetteur utilise la radio ultra-large bande par impulsions (IR-UWB) basée sur l’approche edge combining et le RX utilise la bande ISM (Industrielle, Scientifique et Médicale) de fréquence central 2.4 GHz et la modulation on-off-keying (OOK). Une bonne isolation (> 20 dB) est obtenue entre le TX et le RX grâce à 1) la mise en forme les impulsions émises dans le spectre UWB non réglementée (3.1-7 GHz), et 2) le filtrage espace-efficace (évitant l’utilisation d’un circulateur ou d’un diplexeur) du spectre du lien de communication descendant directement au niveau de l’ amplificateur à faible bruit (LNA). L’émetteur UWB 3.1-7 GHz utilise un e modultion OOK ainsi qu’une modulation par déplacement de phase (BPSK) à seulement 10.8 pJ / bits. Le FDT proposé permet d’atteindre 500 Mbps de débit de données en lien montant et 100 Mbps de débit de données de lien descendant. Il est entièrement intégré dans un procédé TSMC CMOS 0.18 um standard et possède une taille totale de 0.8 mm2. La consommation totale d’énergie mesurée est de 10.4 mW (5 mW pour RX et 5.4 mW pour TX au taux de 500 Mbps).In recent years, there has been major progress on implantable biomedical systems that support most of the functionalities of wireless implantable devices. Nevertheless, these devices remain mostly restricted to be commercialized, in part due to weakness of a straightforward design to support the required functionalities, limitation on miniaturization, and lack of a reliable low-power high data rate interface between implants and external devices. This research provides novel strategies on the design of implantable biomedical devices that addresses these limitations by presenting analysis and techniques for wireless power transfer and efficient data transfer. The first part of this research includes our proposed novel resonance-based multicoil inductive power link structure with uniform power distribution to wirelessly power up smart animal research systems and implanted medical devices with high power efficiency and free positioning capability. The proposed structure consists of a multicoil resonance inductive link, which primary resonator array is made of several identical resonators enclosed in a scalable array of overlapping square coils that are connected in parallel and arranged in power surface (2D) and power chamber (3D) configurations. The proposed chamber uses two arrays of primary resonators, facing each other, and connected in parallel to achieve uniform power distribution in 3D. Each surface includes 9 overlapped coils connected in parallel and implemented into two layers of FR4 printed circuit board. The chamber features a natural power localization mechanism, which simplifies its implementation and eases its operation by avoiding the need for active detection of the load location and power control mechanisms. A single power surface based on the proposed approach can provide a power transfer efficiency (PTE) of 69% and a power delivered to the load (PDL) of 120 mW, for a separation distance of 4 cm, whereas the complete chamber prototype provides a uniform PTE of 59% and a PDL of 100 mW in 3D, everywhere inside the chamber with a chamber size of 27×27×16 cm3. The second part of this research includes our proposed novel, fully-integrated, low-power fullduplex transceiver (FDT) to support bi-directional neural interfacing applications (stimulating and recording) with asymmetric data rates: higher rates are required for recording (uplink signals) than stimulation (downlink signals). The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2.4-GHz on-off keying (OOK) receiver. Proper isolation (> 20 dB) between the TX and RX path is implemented 1) by shaping the transmitted pulses to fall within the unregulated UWB spectrum (3.1-7 GHz), and 2) by space-efficient filtering (avoiding a circulator or diplexer) of the downlink OOK spectrum in the RX low-noise amplifier (LNA). The UWB 3.1-7 GHz transmitter using OOK and binary phase shift keying (BPSK) modulations at only 10.8 pJ/bit. The proposed FDT provides dual band 500 Mbps TX uplink data rate and 100 Mbps RX downlink data rate. It is fully integrated on standard TSMC 0.18 nm CMOS within a total size of 0.8 mm2. The total power consumption measured 10.4 mW (5 mW for RX and 5.4 mW for TX at the rate of 500 Mbps)

Design and miniaturization of a microsystem to power biomedical implants using grey wolf optimizer-based cuckoo search algorithm

One of the greatest techniques, inductive coupling is frequently utilized in the biomedical sector for wireless energy transfer to implants. The aim of this article is to develop and analyze the effect of inductor geometrical characteristics, distance between transmitter (TX) and receiver (RX) and also the operating frequency on the wireless power transfer system, using grey wolf optimizer-based cuckoo search (GWO-CS) algorithm. Power transfer efficiency (PTE), power provided to load, and other critical components must all be improved or maximized and miniaturaze the microsystem proposed. The invention, design, and optimization of coils square spirals in a wireless energy transfer system using a resonant inductive link are the emphasis of this paper. The GWO-CS approach is evaluated to existing methods, demonstrated by simulations and to demonstrate the effectiveness of the suggested strategy

An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects

A new study with rat sciatic nerve model for peripheral nerve interfacing is presented using a fully-implanted inductively-powered recording and stimulation system in a wirelessly-powered standard homecage that allows animal subjects move freely within the homecage. The Wireless Implantable Neural Recording and Stimulation (WINeRS) system offers 32-channel peripheral nerve recording and 4-channel current-controlled stimulation capabilities in a 3 × 1.5 × 0.5 cm3 package. A bi-directional data link is established by on-off keying pulse-position modulation (OOK-PPM) in near field for narrow-band downlink and 433 MHz OOK for wideband uplink. An external wideband receiver is designed by adopting a commercial software defined radio (SDR) for a robust wideband data acquisition on a PC. The WINeRS-8 prototypes in two forms of battery-powered headstage and wirelessly-powered implant are validated in vivo, and compared with a commercial system. In the animal study, evoked compound action potentials were recorded to verify the stimulation and recording capabilities of the WINeRS-8 system with 32-ch penetrating and 4-ch cuff electrodes on the sciatic nerve of awake freely-behaving rats. Compared to the conventional battery-powered system, WINeRS can be used in closed-loop recording and stimulation experiments over extended periods without adding the burden of carrying batteries on the animal subject or interrupting the experiment

Doctor of Philosophy

dissertationMore than a century ago, in his labs in Colorado Springs and New York, Nikola Tesla started experimenting with wireless power transfer (WPT). His ideas were ahead of his time, but they fell into obscurity shortly after his death. Nowadays, WPT is no longer thought of as science fiction: neural prostheses, wearables, cellphones, and even electric vehicles can be powered through WPT. In its most common implementation, WPT leverages the magnetic coupling between resonant transmitter and receiver coils to exchange energy. Considerable work is devoted to the design and optimization of WPT antennas; efficiently transmitting the required amount of power can only be accomplished when the coil coupling is in the right range. In this work, we explore the use of spatial filters in WPT systems. Spatial filters are capable of controlling the harmonic content of an incident wave: subwavelength focal spots, perfect lensing, and diffractionless beams are some of their uses. In the first part of this dissertation, the focus is on the analysis and design of a compact negative permeability metamaterial slab. Compared to other works in the literature, this slab is an extremely small fraction of the wavelength, and works at a low operating frequency. Analysis and experimental validation demonstrate that the resulting metamaterial sample can be used in a 2-coil WPT system to achieve large range and efficiency enhancements. In the second part of this dissertation, the analysis and implementation of holographic screens is presented. A method to reduce the fabrication complexity of the desired holographic screen while maintaining the fidelity of the prescribed field distribution is presented. We demonstrate our method through the analysis, design, and experimental validation of a nondiffractive beam launcher with a Bessel field distribution. Finally, we utilize the analysis and methods presented in this work to design an antenna capable of prescribing a uniform field distribution. Because of this property, this WPT antenna is capable of transmitting near constant power with near constant efficiency to the target receiver load, without the need of an adaptive compensation system

Wireless Power Transfer Techniques for Implantable Medical Devices:A Review

Wireless power transfer (WPT) systems have become increasingly suitable solutions for the electrical powering of advanced multifunctional micro-electronic devices such as those found in current biomedical implants. The design and implementation of high power transfer efficiency WPT systems are, however, challenging. The size of the WPT system, the separation distance between the outside environment and location of the implanted medical device inside the body, the operating frequency and tissue safety due to power dissipation are key parameters to consider in the design of WPT systems. This article provides a systematic review of the wide range of WPT systems that have been investigated over the last two decades to improve overall system performance. The various strategies implemented to transfer wireless power in implantable medical devices (IMDs) were reviewed, which includes capacitive coupling, inductive coupling, magnetic resonance coupling and, more recently, acoustic and optical powering methods. The strengths and limitations of all these techniques are benchmarked against each other and particular emphasis is placed on comparing the implanted receiver size, the WPT distance, power transfer efficiency and tissue safety presented by the resulting systems. Necessary improvements and trends of each WPT techniques are also indicated per specific IMD

A Novel Power-Efficient Wireless Multi-channel Recording System for the Telemonitoring of Electroencephalography (EEG)

This research introduces the development of a novel EEG recording system that is modular, batteryless, and wireless (untethered) with the supporting theoretical foundation in wireless communications and related design elements and circuitry. Its modular construct overcomes the EEG scaling problem and makes it easier for reconfiguring the hardware design in terms of the number and placement of electrodes and type of standard EEG system contemplated for use. In this development, portability, lightweight, and applicability to other clinical applications that rely on EEG data are sought. Due to printer tolerance, the 3D printed cap consists of 61 electrode placements. This recording capacity can however extend from 21 (as in the international 10-20 systems) up to 61 EEG channels at sample rates ranging from 250 to 1000 Hz and the transfer of the raw EEG signal using a standard allocated frequency as a data carrier. The main objectives of this dissertation are to (1) eliminate the need for heavy mounted batteries, (2) overcome the requirement for bulky power systems, and (3) avoid the use of data cables to untether the EEG system from the subject for a more practical and less restrictive setting. Unpredictability and temporal variations of the EEG input make developing a battery-free and cable-free EEG reading device challenging. Professional high-quality and high-resolution analog front ends are required to capture non-stationary EEG signals at microvolt levels. The primary components of the proposed setup are the wireless power transmission unit, which consists of a power amplifier, highly efficient resonant-inductive link, rectification, regulation, and power management units, as well as the analog front end, which consists of an analog to digital converter, pre-amplification unit, filtering unit, host microprocessor, and the wireless communication unit. These must all be compatible with the rest of the system and must use the least amount of power possible while minimizing the presence of noise and the attenuation of the recorded signal A highly efficient resonant-inductive coupling link is developed to decrease power transmission dissipation. Magnetized materials were utilized to steer electromagnetic flux and decrease route and medium loss while transmitting the required energy with low dissipation. Signal pre-amplification is handled by the front-end active electrodes. Standard bio-amplifier design approaches are combined to accomplish this purpose, and a thorough investigation of the optimum ADC, microcontroller, and transceiver units has been carried out. We can minimize overall system weight and power consumption by employing battery-less and cable-free EEG readout system designs, consequently giving patients more comfort and freedom of movement. Similarly, the solutions are designed to match the performance of medical-grade equipment. The captured electrical impulses using the proposed setup can be stored for various uses, including classification, prediction, 3D source localization, and for monitoring and diagnosing different brain disorders. All the proposed designs and supporting mathematical derivations were validated through empirical and software-simulated experiments. Many of the proposed designs, including the 3D head cap, the wireless power transmission unit, and the pre-amplification unit, are already fabricated, and the schematic circuits and simulation results were based on Spice, Altium, and high-frequency structure simulator (HFSS) software. The fully integrated head cap to be fabricated would require embedding the active electrodes into the 3D headset and applying current technological advances to miniaturize some of the design elements developed in this dissertation

Compact Multi-Coil Inductive Power Transfer System with a Dynamic Receiver Position Estimation

Inductive power transfer (IPT) systems with tolerance to the lateral misalignment are advantageous for enhancing the transmitted power, usability and security of the system. In this thesis, a misalignment tolerant multi-coil design is proposed to supply stationary and dynamic battery-free wireless devices. A compact architecture composed of individually switchable 3 layers of printed coils arranged with overlap for excellent surface coverage. A hybrid architecture based on three compact AC supply modules reduces the supply circuit complexity on the sending Seite 2 von 4side. It detects the position of the receiver coil quickly, controls the activation of the transmitting coils and estimates the next receiver position. The proposed architecture reduces the circuit footprint by a factor of 62% compared to common architectures. A transmitter coil activation strategy is proposed based on the detection of the transmitting coils voltage and communication between sending side and receiving side to detect devices to supply nature and position and to differentiate them from other conductive objects in the sending area to the supplying security. The experimental results prove that the proposed architecture has a good performance for different trajectories when the device speed does not exceed 15 mm/s. Besides, the maximum detection time for the initial device position is about 1.6 s. The maximal time interval to check the transmitter coils is around 0.7 s.:1. INTRODUCTION 2. THEORETICAL BACKGROUND 3. STATE OF THE ART OF MULTI-COIL IPT SYSTEMS 4. NOVEL DESIGN OF A MULTI-COIL IPT SYSTEM 5. MULTI-COIL ACTIVATION PROCEDURE 6. EXPERIMENTAL INVESTIGATIONS 7. CONCLUSION AND OUTLOOKInduktive Energieübertragungssysteme (IPT) mit Toleranz gegenüber seitlichem Versatz sind vorteilhaft, um die übertragene Leistung, die Nutzbarkeit und die Sicherheit des Systems zu verbessern. In dieser Arbeit wird ein versatztolerantes Multispulen-Design vorgeschlagen, um stationäre und dynamische batterielose drahtlose Geräte zu versorgen. Die kompakte Architektur besteht aus 3 einzeln schaltbaren Schichten gedruckter Spulen, die überlappend angeordnet sind, um eine hervorragende Oberflächenabdeckung zu gewährleisten. Eine hybride Architektur, die auf drei kompakten AC-Versorgungsmodulen basiert, reduziert die Komplexität der Versorgungsschaltung auf der Senderseite. Sie erkennt die Position der Empfängerspule schnell, steuert die Aktivierung der Sendespulen und schätzt die nächste Empfängerposition. Die vorgeschlagene Architektur reduziert den Platzbedarf der Schaltung um einen Faktor von 62 % im Vergleich zu herkömmlichen Architekturen. Es wird eine Aktivierungsstrategie für die Sendespulen vorgeschlagen, die auf der Erkennung der Spannung der Sendespulen und der Kommunikation zwischen Sende- und Empfangsseite basiert, um die Art und Position der zu versorgenden Geräte zu erkennen und sie von anderen leitfähigen Objekten im Sendebereich zu unterscheiden. Die experimentellen Ergebnisse zeigen, dass die vorgeschlagene Architektur eine gute Leistung für verschiedene Trajektorien hat, wenn die Geschwindigkeit der Geräte 15 mm/s nicht überschreitet. Außerdem beträgt die maximale Erkennungszeit für die anfängliche Geräteposition etwa 1,6 s. Das maximale Zeitintervall für die Überprüfung der Senderspulen beträgt etwa 0,7 s.:1. INTRODUCTION 2. THEORETICAL BACKGROUND 3. STATE OF THE ART OF MULTI-COIL IPT SYSTEMS 4. NOVEL DESIGN OF A MULTI-COIL IPT SYSTEM 5. MULTI-COIL ACTIVATION PROCEDURE 6. EXPERIMENTAL INVESTIGATIONS 7. CONCLUSION AND OUTLOO

Inductive Wireless Power Transfer Charging for Electric vehicles - A Review

Considering a future scenario in which a driverless Electric Vehicle (EV) needs an automatic charging system without human intervention. In this regard, there is a requirement for a fully automatable, fast, safe, cost-effective, and reliable charging infrastructure that provides a profitable business model and fast adoption in the electrified transportation systems. These qualities can be comprehended through wireless charging systems. Wireless Power Transfer (WPT) is a futuristic technology with the advantage of flexibility, convenience, safety, and the capability of becoming fully automated. In WPT methods resonant inductive wireless charging has to gain more attention compared to other wireless power transfer methods due to high efficiency and easy maintenance. This literature presents a review of the status of Resonant Inductive Wireless Power Transfer Charging technology also highlighting the present status and its future of the wireless EV market. First, the paper delivers a brief history throw lights on wireless charging methods, highlighting the pros and cons. Then, the paper aids a comparative review of different type’s inductive pads, rails, and compensations technologies done so far. The static and dynamic charging techniques and their characteristics are also illustrated. The role and importance of power electronics and converter types used in various applications are discussed. The batteries and their management systems as well as various problems involved in WPT are also addressed. Different trades like cyber security economic effects, health and safety, foreign object detection, and the effect and impact on the distribution grid are explored. Prospects and challenges involved in wireless charging systems are also highlighting in this work. We believe that this work could help further the research and development of WPT systems.publishedVersio

Doctor of Philosophy

dissertationMagnetic fields are permeable to the biological tissues and can induce electric field in the conductive structures. Some medical devices take advantage of this ability to transfer energy from the source to the receiving site without direct contact. Prosthetic devices such as retinal implants use time-varying magnetic field to achieve wireless power transfer to the implanted magnetic coil. However, devices such as magnetic stimulators use the induction principle to create an electric field at the stimulation site. Efficiency of these devices is primarily dependent on the design of the magnetic coils. Therefore, in this work, we designed and validated efficient magnetic coils for wireless power transfer to implanted devices and magnetic stimulation of the peripheral nerves. Typical wireless power transfer (WPT) systems uses two-coil based design to achieve contactless power transfer to the implanted electronics. These systems achieve low power transfer efficiency (< 30%) and frequency bandwidth. Moreover, efficient wireless system requires high coupling and load variation tolerance during device operation. To design an electromagnetic safe WPT system, the power absorbed by the tissue and radiated field due to the proximal magnetic coils needs to be minimized. In this work, we proposed a multi-coil power transfer system which solves some of the current challenges. The proposed multi-coil WPT system achieves more than twice the power transfer efficiency, controllable voltage gain, wider frequency bandwidth, higher tolerance to coupling and load variations, lower absorbed power in the tissue and lower radiated field from the magnetic coil than a comparable two-coil system. In this work, we have developed analytic models of the multi-coil WPT system and validated the accuracy of the solutions using experiments. Magnetic coils play an important role in controlling the distribution of induced electric field inside the nerve during magnetic stimulation. In the past, homogeneous models were used to estimate the field profile inside conductive tissue due to the time varying current in the magnetic coil. Moreover, the effect of the surrounding media and stimulation mechanisms was understudied, which limits the optimization accuracy of the magnetic coils. In this work, we developed anatomically correct tissue models to study the effect of tissue heterogeneity and the surrounding media on the induced electric field. We also developed an optimization algorithm for designing energy efficient cm-size magnetic coils, that were then used for ex-vivo magnetic stimulation of the frog's sciatic nerve