Moving magnetoencephalography towards real-world applications with a wearable system

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessible to many people, and limits the experimental questions that can be addressed. For example, it has been difficult to apply neuroimaging to investigation of the neural substrates of cognitive development in babies and children, or in adult studies that require unconstrained head movement (e.g. spatial navigation). Here, we develop a new type of MEG system that can be worn like a helmet, allowing free and natural movement during scanning. This is possible due to the integration of new quantum sensors2,3 that do not rely on superconducting technology, with a novel system for nulling background magnetic fields. We demonstrate human electrophysiological measurement at millisecond resolution whilst subjects make natural movements, including head nodding, stretching, drinking and playing a ball game. Results compare well to the current state-of-the-art, even when subjects make large head movements. The system opens up new possibilities for scanning any subject or patient group, with myriad applications such as characterisation of the neurodevelopmental connectome, imaging subjects moving naturally in a virtual environment, and understanding the pathophysiology of movement disorders

Localising epileptiform activity and eloquent cortex using magnetoencephalography

In patients with drug resistant epilepsy, the surgical resection of epileptogenic cortex allows the possibility for seizure freedom, provided that epileptogenic and eloquent brain tissue can be accurately identified prior to surgery. This is often achieved using various techniques including neuroimaging, electroencephalographic (EEG), neuropsychological and invasive measurements. Over the last 20 years, magnetoencephalography (MEG) has emerged as a non-invasive tool that can provide important clinical information to patients with suspected neocortical epilepsy being considered for surgery. The standard clinical MEG analyses to localise abnormalities are not always successful and therefore the development and evaluation of alternative methods are warranted. There is also a continuous need to develop MEG techniques to delineate eloquent cortex. Based on this rationale, this thesis is concerned with the presurgical evaluation of drug resistant epilepsy patients using MEG and consists of two themes: the first theme focuses on the refinement of techniques to functionally map the brain and the second focuses on evaluating alternative techniques to localise epileptiform activity. The first theme involved the development of an alternative beamformer pipeline to analyse Elekta Neuromag data and was subsequently applied to data acquired using a pre-existing and a novel language task. The findings of the second theme demonstrated how beamformer based measures can objectively localise epileptiform abnormalities. A novel measure, rank vector entropy, was introduced to facilitate the detection of multiple types of abnormal signals (e.g. spikes, slow waves, low amplitude transients). This thesis demonstrates the clinical capacity of MEG and its role in the presurgical evaluation of drug resistant epilepsy patients

Neuromagnetic Decomposition of Social Interaction

Not Available

Reconstruction Methods for Free-Breathing Dynamic Contrast-Enhanced MRI

Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is a valuable diagnostic tool due to the combination of anatomical and physiological information it provides. However, the sequential sampling of MRI presents an inherent tradeoff between spatial and temporal resolution. Compressed Sensing (CS) methods have been applied to undersampled MRI to reconstruct full-resolution images at sub-Nyquist sampling rates. In exchange for shorter data acquisition times, CS-MRI requires more computationally intensive iterative reconstruction methods. We present several model-based image reconstruction (MBIR) methods to improve the spatial and temporal resolution of MR images and/or the computational time for multi-coil MRI reconstruction. We propose efficient variable splitting (VS) methods for support-constrained MRI reconstruction, image reconstruction and denoising with non-circulant boundary conditions, and improved temporal regularization for breast DCE-MRI. These proposed VS algorithms decouple the system model and sparsity terms of the convex optimization problem. By leveraging matrix structures in the system model and sparsifying operator, we perform alternating minimization over a list of auxiliary variables, each of which can be performed efficiently. We demonstrate the computational benefits of our proposed VS algorithms compared to similar proposed methods. We also demonstrate convergence guarantees for two proposed methods, ADMM-tridiag and ADMM-FP-tridiag. With simulation experiments, we demonstrate lower error in spatial and temporal dimensions for these VS methods compared to other object models. We also propose a method for indirect motion compensation in 5D liver DCE-MRI. 5D MRI separates temporal changes due to contrast from anatomical changes due to respiratory motion into two distinct dimensions. This work applies a pre-computed motion model to perform motion-compensated regularization across the respiratory dimension and improve the conditioning of this highly sparse 5D reconstruction problem. We demonstrate a proof of concept using a digital phantom with contrast and respiratory changes, and we show preliminary results for motion model-informed regularization on in vivo patient data.PHDElectrical Engineering: SystemsUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttps://deepblue.lib.umich.edu/bitstream/2027.42/138498/1/mtle_1.pd

Quality control of visual gamma oscillation frequency in studies of pharmacology, cognitive neuroscience and large-scale multi-site collaborations

In visual cortex, high-contrast grating stimuli induce neurons to oscillate synchronously with a centre frequency in the gamma range (~30–80 Hz). The peak frequency of visual gamma oscillations is modulated by numerous factors, including stimulus properties, cortical architecture and genetics, however, it can be measured reliably over time. As demonstrated by both animal models and human pharmacological studies, the gamma peak frequency is determined by the excitation/inhibition balance and the time constants of GABAergic processes. This oscillatory parameter could thus reflect inter-individual differences in cortical function/physiology, representing a possible biomarker for pharmacological treatment in conditions such as epilepsy, autism and schizophrenia. This thesis demonstrates the importance of measuring the gamma peak frequency accurately and reliably in magnetoencephalographic (MEG) recordings. In Chapter 2, a novel quality-control (QC) approach was validated for peak frequency estimation and identification of poor-quality data. In Chapter 3, QC of a previous pharmacological MEG study of visual gamma with tiagabine revealed a marked drug-induced reduction of peak frequency. Although contrasting with the null finding originally reported (Muthukumaraswamy et al., 2013), the result is supported by both animal models and recent human studies, demonstrating the potentialities of appropriate QC routines. In Chapter 4, testing for the effect of spatial attention on the gamma peak frequency in primary visual cortex resulted in no evidence of a change. However, the modulation of gamma amplitude by attention was consistent with a role in feed-forward signal propagation across the visual hierarchy. In Chapter 5, the QC approach was used to compare visual gamma data recorded at different sites of the UK MEG Partnership, demonstrating the feasibility of combining data from different MEG systems. These results have implications particularly for pharmacological and large-scale multi-site studies, both of which are emerging as promising approaches for the study of brain function with MEG

Image and Video Forensics

Nowadays, images and videos have become the main modalities of information being exchanged in everyday life, and their pervasiveness has led the image forensics community to question their reliability, integrity, confidentiality, and security. Multimedia contents are generated in many different ways through the use of consumer electronics and high-quality digital imaging devices, such as smartphones, digital cameras, tablets, and wearable and IoT devices. The ever-increasing convenience of image acquisition has facilitated instant distribution and sharing of digital images on digital social platforms, determining a great amount of exchange data. Moreover, the pervasiveness of powerful image editing tools has allowed the manipulation of digital images for malicious or criminal ends, up to the creation of synthesized images and videos with the use of deep learning techniques. In response to these threats, the multimedia forensics community has produced major research efforts regarding the identification of the source and the detection of manipulation. In all cases (e.g., forensic investigations, fake news debunking, information warfare, and cyberattacks) where images and videos serve as critical evidence, forensic technologies that help to determine the origin, authenticity, and integrity of multimedia content can become essential tools. This book aims to collect a diverse and complementary set of articles that demonstrate new developments and applications in image and video forensics to tackle new and serious challenges to ensure media authenticity