1,727 research outputs found
Automatic Pulmonary Nodule Detection in CT Scans Using Convolutional Neural Networks Based on Maximum Intensity Projection
Accurate pulmonary nodule detection is a crucial step in lung cancer
screening. Computer-aided detection (CAD) systems are not routinely used by
radiologists for pulmonary nodule detection in clinical practice despite their
potential benefits. Maximum intensity projection (MIP) images improve the
detection of pulmonary nodules in radiological evaluation with computed
tomography (CT) scans. Inspired by the clinical methodology of radiologists, we
aim to explore the feasibility of applying MIP images to improve the
effectiveness of automatic lung nodule detection using convolutional neural
networks (CNNs). We propose a CNN-based approach that takes MIP images of
different slab thicknesses (5 mm, 10 mm, 15 mm) and 1 mm axial section slices
as input. Such an approach augments the two-dimensional (2-D) CT slice images
with more representative spatial information that helps discriminate nodules
from vessels through their morphologies. Our proposed method achieves
sensitivity of 92.67% with 1 false positive per scan and sensitivity of 94.19%
with 2 false positives per scan for lung nodule detection on 888 scans in the
LIDC-IDRI dataset. The use of thick MIP images helps the detection of small
pulmonary nodules (3 mm-10 mm) and results in fewer false positives.
Experimental results show that utilizing MIP images can increase the
sensitivity and lower the number of false positives, which demonstrates the
effectiveness and significance of the proposed MIP-based CNNs framework for
automatic pulmonary nodule detection in CT scans. The proposed method also
shows the potential that CNNs could gain benefits for nodule detection by
combining the clinical procedure.Comment: Submitted to IEEE TM
Highly accurate model for prediction of lung nodule malignancy with CT scans
Computed tomography (CT) examinations are commonly used to predict lung
nodule malignancy in patients, which are shown to improve noninvasive early
diagnosis of lung cancer. It remains challenging for computational approaches
to achieve performance comparable to experienced radiologists. Here we present
NoduleX, a systematic approach to predict lung nodule malignancy from CT data,
based on deep learning convolutional neural networks (CNN). For training and
validation, we analyze >1000 lung nodules in images from the LIDC/IDRI cohort.
All nodules were identified and classified by four experienced thoracic
radiologists who participated in the LIDC project. NoduleX achieves high
accuracy for nodule malignancy classification, with an AUC of ~0.99. This is
commensurate with the analysis of the dataset by experienced radiologists. Our
approach, NoduleX, provides an effective framework for highly accurate nodule
malignancy prediction with the model trained on a large patient population. Our
results are replicable with software available at
http://bioinformatics.astate.edu/NoduleX
Multi-scale analysis of lung computed tomography images
A computer-aided detection (CAD) system for the identification of lung
internal nodules in low-dose multi-detector helical Computed Tomography (CT)
images was developed in the framework of the MAGIC-5 project. The three modules
of our lung CAD system, a segmentation algorithm for lung internal region
identification, a multi-scale dot-enhancement filter for nodule candidate
selection and a multi-scale neural technique for false positive finding
reduction, are described. The results obtained on a dataset of low-dose and
thin-slice CT scans are shown in terms of free response receiver operating
characteristic (FROC) curves and discussed.Comment: 18 pages, 12 low-resolution figure
Towards automatic pulmonary nodule management in lung cancer screening with deep learning
The introduction of lung cancer screening programs will produce an
unprecedented amount of chest CT scans in the near future, which radiologists
will have to read in order to decide on a patient follow-up strategy. According
to the current guidelines, the workup of screen-detected nodules strongly
relies on nodule size and nodule type. In this paper, we present a deep
learning system based on multi-stream multi-scale convolutional networks, which
automatically classifies all nodule types relevant for nodule workup. The
system processes raw CT data containing a nodule without the need for any
additional information such as nodule segmentation or nodule size and learns a
representation of 3D data by analyzing an arbitrary number of 2D views of a
given nodule. The deep learning system was trained with data from the Italian
MILD screening trial and validated on an independent set of data from the
Danish DLCST screening trial. We analyze the advantage of processing nodules at
multiple scales with a multi-stream convolutional network architecture, and we
show that the proposed deep learning system achieves performance at classifying
nodule type that surpasses the one of classical machine learning approaches and
is within the inter-observer variability among four experienced human
observers.Comment: Published on Scientific Report
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