29,294 research outputs found
Knowing Your Population: Privacy-Sensitive Mining of Massive Data
Location and mobility patterns of individuals are important to environmental
planning, societal resilience, public health, and a host of commercial
applications. Mining telecommunication traffic and transactions data for such
purposes is controversial, in particular raising issues of privacy. However,
our hypothesis is that privacy-sensitive uses are possible and often beneficial
enough to warrant considerable research and development efforts. Our work
contends that peoples behavior can yield patterns of both significant
commercial, and research, value. For such purposes, methods and algorithms for
mining telecommunication data to extract commonly used routes and locations,
articulated through time-geographical constructs, are described in a case study
within the area of transportation planning and analysis. From the outset, these
were designed to balance the privacy of subscribers and the added value of
mobility patterns derived from their mobile communication traffic and
transactions data. Our work directly contrasts the current, commonly held
notion that value can only be added to services by directly monitoring the
behavior of individuals, such as in current attempts at location-based
services. We position our work within relevant legal frameworks for privacy and
data protection, and show that our methods comply with such requirements and
also follow best-practice
BCAS: A Web-enabled and GIS-based Decision Support System for the Diagnosis and Treatment of Breast Cancer
For decades, geographical variations in cancer rates have been observed but the precise determinants of such geographic differences in breast cancer development are unclear. Various statistical models have been proposed. Applications of these models, however, require that the data be assembled from a variety of sources, converted into the statistical models’ parameters and delivered effectively to researchers and policy makers. A web-enabled and GIS-based system can be developed to provide the needed functionality. This article overviews the conceptual web-enabled and GIS-based system (BCAS), illustrates the system’s use in diagnosing and treating breast cancer and examines the potential benefits and implications for breast cancer research and practice
EDMON - Electronic Disease Surveillance and Monitoring Network: A Personalized Health Model-based Digital Infectious Disease Detection Mechanism using Self-Recorded Data from People with Type 1 Diabetes
Through time, we as a society have been tested with infectious disease outbreaks of different magnitude, which often pose major public health challenges. To mitigate the challenges, research endeavors have been focused on early detection mechanisms through identifying potential data sources, mode of data collection and transmission, case and outbreak detection methods. Driven by the ubiquitous nature of smartphones and wearables, the current endeavor is targeted towards individualizing the surveillance effort through a personalized health model, where the case detection is realized by exploiting self-collected physiological data from wearables and smartphones.
This dissertation aims to demonstrate the concept of a personalized health model as a case detector for outbreak detection by utilizing self-recorded data from people with type 1 diabetes. The results have shown that infection onset triggers substantial deviations, i.e. prolonged hyperglycemia regardless of higher insulin injections and fewer carbohydrate consumptions. Per the findings, key parameters such as blood glucose level, insulin, carbohydrate, and insulin-to-carbohydrate ratio are found to carry high discriminative power. A personalized health model devised based on a one-class classifier and unsupervised method using selected parameters achieved promising detection performance. Experimental results show the superior performance of the one-class classifier and, models such as one-class support vector machine, k-nearest neighbor and, k-means achieved better performance. Further, the result also revealed the effect of input parameters, data granularity, and sample sizes on model performances.
The presented results have practical significance for understanding the effect of infection episodes amongst people with type 1 diabetes, and the potential of a personalized health model in outbreak detection settings. The added benefit of the personalized health model concept introduced in this dissertation lies in its usefulness beyond the surveillance purpose, i.e. to devise decision support tools and learning platforms for the patient to manage infection-induced crises
Aerospace Medicine and Biology: A continuing bibliography with indexes (supplement 156)
This bibliography lists 170 reports, articles, and other documents introduced into the NASA scientific and technical information system in June 1976
Code, space and everyday life
In this paper we examine the role of code (software) in the spatial formation of
collective life. Taking the view that human life and coded technology are folded into
one another, we theorise space as ontogenesis. Space, we posit, is constantly being
bought into being through a process of transduction – the constant making anew of a
domain in reiterative and transformative practices - as an incomplete solution to a
relational problem. The relational problem we examine is the ongoing encounter
between individuals and environment where the solution, to a greater or lesser extent,
is code. Code, we posit, is diversely embedded in collectives as coded objects, coded
infrastructure, coded processes and coded assemblages. These objects, infrastructure,
processes and assemblages possess technicity, that is, unfolding or evolutive power to
make things happen; the ability to mediate, supplement, augment, monitor, regulate,
operate, facilitate, produce collective life. We contend that when the technicity of
code is operationalised it transduces one of three forms of hybrid spatial formations:
code/space, coded space and backgrounded coded space. These formations are
contingent, relational, extensible and scaleless, often stretched out across networks of
greater or shorter length. We demonstrate the coded transduction of space through
three vignettes – each a day in the life of three people living in London, UK, tracing
the technical mediation of their interactions, transactions and mobilities. We then
discuss how code becomes the relational solution to five different classes of problems
– domestic living, travelling, working, communicating, and consuming
Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England
Purebred dog health is thought to be compromised by an increasing occurence of inherited diseases but inadequate prevalence data on common disorders have hampered efforts to prioritise health reforms. Analysis of primary veterinary practice clinical data has been proposed for reliable estimation of disorder prevalence in dogs. Electronic patient record (EPR) data were collected on 148,741 dogs attending 93 clinics across central and south-eastern England. Analysis in detail of a random sample of EPRs relating to 3,884 dogs from 89 clinics identified the most frequently recorded disorders as otitis externa (prevalence 10.2%, 95% CI: 9.1-11.3), periodontal disease (9.3%, 95% CI: 8.3-10.3) and anal sac impaction (7.1%, 95% CI: 6.1-8.1). Using syndromic classification, the most prevalent body location affected was the head-and-neck (32.8%, 95% CI: 30.7-34.9), the most prevalent organ system affected was the integument (36.3%, 95% CI: 33.9-38.6) and the most prevalent pathophysiologic process diagnosed was inflammation (32.1%, 95% CI: 29.8-34.3). Among the twenty most-frequently recorded disorders, purebred dogs had a significantly higher prevalence compared with crossbreds for three: otitis externa (P = 0.001), obesity (P = 0.006) and skin mass lesion (P = 0.033), and popular breeds differed significantly from each other in their prevalence for five: periodontal disease (P = 0.002), overgrown nails (P = 0.004), degenerative joint disease (P = 0.005), obesity (P = 0.001) and lipoma (P = 0.003). These results fill a crucial data gap in disorder prevalence information and assist with disorder prioritisation. The results suggest that, for maximal impact, breeding reforms should target commonly-diagnosed complex disorders that are amenable to genetic improvement and should place special focus on at-risk breeds. Future studies evaluating disorder severity and duration will augment the usefulness of the disorder prevalence information reported herein
Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia
Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials
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