Here, we have isolated and examined AMR patterns of 654 enteric
pathogens and investigated complete genome sequences of isolates from
six representative genera, which in aggregate encode resistance against
22 antibiotics representing nine distinct drug classes. This study
revealed that ~97% isolates are resistant against ≥2 antibiotics, ~24%
isolates are resistant against ≥10 antibiotics and ~3% isolates are
resistant against ≥15 antibiotics. Analyses of whole genome sequences of
six extensive drug resistant enteric pathogens revealed presence of
multiple mobile genetic elements, which are physically linked with
resistance traits. These elements are therefore appearing to be
responsible for disseminating drug resistance among bacteria through
horizontal gene transfer. The present study provides insights into the
linkages between the resistance patterns to certain antibiotics and
their usage in India
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