Pemberian Kombinasi Vitamin B1, B6 dan B12 sebagai Faktor Determinan Penurunan Nilai Total Gejala pada Pasien Neuropati Perifer Diabetik

Diabetic neuropathy is defined as symptoms of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes. According to the earlier studies symptoms of neuropathy such as pain, burning, paresthesia/tingling and numbness can be reduced with neurotropic supplementation. The aim of the research is to determine vitamin B1, ­B6 and B12 as a determinant factor in the reduce total symptom score in patient with diabetic peripheral neuropathy. This research used case series studies and choose 43 sample with consecutive sampling method. We observed symptoms of diabetic peripheral neuropathy (pain, burning, tingling and numbness) measured as total symptoms score, among the patients treated with vitamin B1 (100mg), ­B6 (100mg) and B12 (5000mcg) for a month. Measurement of total symptoms score performed at first meeting, the second week later (day-14) and the fourth week later (day-30). The data were analyzed using univariate and bivariate statistics. The patients (n=43) consisted of 20 male (46.5 %) and 23 female (53.5 %). The symptoms of diabetic peripheral neuropathy (pain, burning, tingling and numbness) that measured by total symptoms score compared with first visit (4.70 ± 1.83), second visit (2.99 ± 1.61) and third (2:37 ± 1.62). Bivariate analysis, showed a correlation between a reduction in total symptoms score after giving therapy of vitamin B1 (100mg), ­B6 (100mg) and B12 (5000mcg) with p = 0.00. Vitamin B1, ­B6 and B12 proved to be a determinant factor to reduce total symptoms score (pain, burning, tingling, and numbness) in patients with diabetic peripheral neuropathy

Efficacy of Vitamin B1, B6, and B12 Forte Therapy in Peripheral Neuropathy Patients

Background: Peripheral neuropathy can be caused by diabetes mellitus, nutritional deficiencies, entrapment or Carpal Tunnel Syndrome (CTS), and idiopathic.Objective: To determine the therapeutic efficacy of Vitamin B1, B6, and B12 forte in relieving symptoms of peripheral neuropathy.Methods: This was pre- and post-experimental study involving patients with moderate peripheral neuropathy (Toronto Clinical Neuropathy Score [TCNS] ≥6 and Michigan Neuropathy Screening Instrument [MNSI] ≥7) taken from outpatient neurological clinic of Dr. Kariadi Hospital, Semarang. The patient was prescribed Vit B1 100 mg, B6 100 mg, and B12 5000 mcg once daily for 2 months. Evaluation of the numerical pain rating scale in the form of VAS and Total Symptom Score (TSS) was conducted at the first and second month. The VAS score difference test was conducted with the Wilcoxon test and TSS with the Post Hoc test and considered significant if p <0.05.Results: There were 30 patients aged 18 - 65 years, consisted of 70% female and 30% male. The etiology of peripheral neuropathy were idiopathic (40%), CTS (26.7%), DM (23.3%), and HNP (10%). There were significant differences of the VAS scale  and TSS at every evaluations.Conclusion: Administration of VitB1, B6, and B12 forte relieved symptoms of moderate peripheral neuropathy with improvement of VAS and TSS score

Changes in Life Quality of Chronic Kidney Disease Patients with Hemodialysis Who Are Given Vitamin B1, B6, and B12 Parenterally

Background: Chronic kidney disease (CKD) is a disease that causes a progressive decrease in kidney function, which can end in kidney failure disease and will have an impact on decreasing quality of life. Previous research has shown that by giving vitamins B1, B6, and B12 can improve quality of life. Aim: To measure changes in quality of life in patients with chronic kidney disease who were given vitamins B1, B6, and B12 parenterally. Material and Methods: This study used quasi experimental (one group pre and post test) in 117 patients who were selected in Bethesda Hospital and Panti Rapih Hospital Yogyakarta hemodialysis unit. Patients were given vitamins B Combination injections twice a week in each hemodialysis for 4 weeks. Quality of life was measured by SF-8 questionnaire on the first day of hemodialysis before given vitamins (pre-test) and on the 30th day, after eight injection of vitamins B1, B6, and B12 (post test). Results: The mean age of observed patients were 51.58 ± 12.51 years. From 117 patients, 73 patients (62,4%) were male and 44 patients (37.6%) were female. The improvement in overall quality of life in patients was not significant (p= 0.055). Quality of life improvement was only significant in the male group (p = 0.016). Conclusion: There was no significant difference after 4-weeks-injections of vitamins B Combination to the overall quality of life in chronic kidney disease patients undergoing hemodialysis. But there was found a significant improvement in quality of life in the male patients with chronic kidney disease who had hemodialysis. Keywords : chronic kidney disease, quality of life, vitamins B1, B6, and B12, SF-8 questionnaire

Supplement Consumption among Post stroke Patients in Dr. Hasan Sadikin General Hospital Bandung

Background: Stroke is one of the leading causes of global disability. Post stroke rehabilitation program becomes the key to gain functional recovery. Thus it minimizes disabilities. Multiple studies have been carried out to gain greater functional outcomes for post stroke patients, including medical therapy such as supplements. However, supplement effectiveness in providing stroke recovery or prevention is still debatable. There is no data of supplement consumption among post stroke patients; therefore, the aim of this study was to determine the supplement consumption among post stroke patients.Methods: This study was a cross sectional descriptive study using primary data with a consecutive sampling method. Minimum samples for this study were 42 post stroke respondents who followed rehabilitation program. This study was conducted at Physical Medicine and Rehabilitation Clinic of Dr. Hasan Sadikin General Hospital Bandung from June until November 2013. The interviews were done after written informed consent was obtained. Descriptive statistics such as frequency distributin and proportion were used to analyze the data.Results: From 42 respondents, 23 (55%) respondents consumed the supplement. From 34 supplements recorded, 56% were herbs supplements; followed by multivitamin (29%), mineral (6%), multivitamin and mineral (6%), and other supplement (3%). The most frequent ingredients composed in the supplements were B1, B6 and B12 vitamin (7%).Conclusions: More than a half of post stroke patients at Physical Medicine and Rehabilitation Clinic Dr. Hasan Sadikin General Hospital are supplement users, with herbal supplements as the majority. The most frequent ingredients used are B1, B6 and B12 vitamin. [AMJ.2016;3(3):451–8]DOI: 10.15850/amj.v3n3.86

A prospective observational study on prescribing patterns of drugs used in alcoholic liver disease patients at tertiary care teaching hospital

Background: Rational drug prescribing can be defined as appropriate drugs prescribed in the right dose, at correct time intervals and for a sufficient duration. Alcoholic Liver Disease (ALD) and its complications are the principle cause for morbidity and mortality rate and accounts for elevated social and economic costs. The drug use will be a challenge for the physicians as there was no specific treatment for ALD, and decisions regarding treatment are critically depends on the symptoms and complications.Methods: A uni-centric prospective (observational) study was conducted for a period of 6months, to evaluate the current prescribing patterns used in treating ALD. All the patients admitted with diagnosis of ALD in General medicine department, both male and female medical wards were included in the study. General medicine outpatient department, special population such as pregnancy and psychiatry, patients below 18years and those who are not willing to sign in informed consent form was excluded from the study.Results: Number of males (98.02%) between age group 31-40years (29.6%) was more prone when compared to females (1.77%). Portal hypertension (30.35%) followed by jaundice (11.30%) and Ascites (10.71%) were frequently observed complications associated co-morbidities with ALD. WHO prescribing indicators showed deviation from there standard reference values. Diuretics (15.73%), antibiotics (13.14%), vitamin supplements (11.11%) and antacids (10.13%) categories were the most commonly prescribed for patients. The drugs prescribed from NLEM-2015 (82.11%) shows deviation from standard values.Conclusions: Futhermore, multi-centered studies should be conducted to draw best results on prescribing patterns of ALD in India

Pharmacy Newsletter : October 2020

Content: Medication Reconciliation – Call for Focus Medication Errors | Look alike Drug Interaction Corner: Benzodiazepine & Opioids What Do We Need to Know about Remdesivir A Question From Toxicology| American Academy of Clinical Toxicology COVID-19 Pandemic, It’s Time to get back on track with Children’s Immunizationhttps://ecommons.aku.edu/pharmacy_newsletter/1036/thumbnail.jp

Perbedaan Antara Asupan Vitamin B1, B6 Dan B12 Dengan Kejadian Dysmenorrhea Pada Remaja Putri Di Sman 8 Kota Malang Dan Ma Nurul Ulum Munjungan Kabupaten Trenggalek

Dysmenorrhea merupakan salah satu masalah menstruasi yang paling sering dialami oleh remaja putri. Dysmenorrhea dibagi menjadi dysmenorrhe primer dan sekunder. Dysmenorrhea terjadi tanpa disertai patologi organ pelvik. Kekurangan mikronutrien yakni vitamin B1, B6 dan B12 merupakan salah satu faktor penyebab dari dysmenorrhe primer. Konsumsi seimbang dari ketiga vitamin pada menu harian dapat mencegah terjadinya dysmenorrhe primer karena ketiga vitamin ini mampu menghambat sintesa prostaglandin. Penelitian ini bertujuan untuk mengetahui perbedaan antara asupan vitamin B1, B6 dan B12 dengan kejadian dysmenorrhea pada remaja di SMAN 8 Kota Malang dan MA Nurul Ulum Munjungan, Trenggalek. Desain penelitian yang digunakan adalah observasional analitik menggunakan metode cross sectional. Sampel dalam penelitian ini berjumlah 84 orang yang dipilih dengan menggunakan teknik proportional stratified random sampling. Uji analisis hubungan asupan Vitamin B1, B6 dan B12 dengan kejadian dysmenorrhea menggunakan uji Spearman Rank dan Regresi Linier. Hasil uji Spearman diperoleh nilai p<0,05 untuk hubungan asupan Vitamin B1, B6 dan B12 dengan kejadian dysmenorrhea. Hasil analisis Regresi Linier diperoleh p<0,05. Uji beda dilakukan untuk melihat adanya perbedaan antara asupan vitamin B1, B6 dan B12 dari kedua sekolah dilakukan menggunakan uji MannWhitney. Hasil uji menunjukkan p>0,05. Sehingga dapat disimpulkan bahwa tidak ada perbedaan asupan vitamin B1, B6 dan B12 dari SMAN 8 Kota Malang dan MA Nurul Ulum Munjungan, akan tetapi zat mikronutrien yang paling berpengaruh dari kedua sekolah berbeda. Vitamin B12 merupakan vitamin yang paling berpengaruh di SMAN 8 Kota Malang, sedangkan di MA Nurul Ulum Munjungan Vitamin B1 yang paling berpengaruh

Supplement Consumption among Post stroke Patients in Dr. Hasan Sadikin General Hospital Bandung

Background: Stroke is one of the leading causes of global disability. Post stroke rehabilitation program becomes the key to gain functional recovery. Thus it minimizes disabilities. Multiple studies have been carried out to gain greater functional outcomes for post stroke patients, including medical therapy such as supplements. However, supplement effectiveness in providing stroke recovery or prevention is still debatable. There is no data of supplement consumption among post stroke patients; therefore, the aim of this study was to determine the supplement consumption among post stroke patients.Methods: This study was a cross sectional descriptive study using primary data with a consecutive sampling method. Minimum samples for this study were 42 post stroke respondents who followed rehabilitation program. This study was conducted at Physical Medicine and Rehabilitation Clinic of Dr. Hasan Sadikin General Hospital Bandung from June until November 2013. The interviews were done after written informed consent was obtained. Descriptive statistics such as frequency distributin and proportion were used to analyze the data.Results: From 42 respondents, 23 (55%) respondents consumed the supplement. From 34 supplements recorded, 56% were herbs supplements; followed by multivitamin (29%), mineral (6%), multivitamin and mineral (6%), and other supplement (3%). The most frequent ingredients composed in the supplements were B1, B6 and B12 vitamin (7%).Conclusions: More than a half of post stroke patients at Physical Medicine and Rehabilitation Clinic Dr. Hasan Sadikin General Hospital are supplement users, with herbal supplements as the majority. The most frequent ingredients used are B1, B6 and B12 vitamin. [AMJ.2016;3(3):451–8]DOI: 10.15850/amj.v3n3.86