Drug adherence in patient group with Parkinson's disease

Background Patients with Parkinson’s disease needs medicines administered frequently to manage their condition and maintain their quality of life. Poor medicine adherence may influence health negatively, and cause an unnecessary medicine wastage. It is therefore important that they are effectively supported to ensure that they adhere to their medicine regime. The aim of the study is to identify barriers to medicine adherence in patients with Parkinson’s disease or Parkinsonism and to identify interventions to improve medicine adherence. Method A postal questionnaire containing 39 statements was sent to 430 patients. The statements were used to identify patient barriers to adherence. A focus group consisting of healthcare professionals discussed interventions to improve medicine adherence. Results 229 (53,3%) patients responded to the questionnaire. The main barriers to adherence are; having enough time with doctor and pharmacist; being requested to attend to follow-up sessions; knowing where to get help if needed; having the ability to solve problems appearing when taking medicines; worry about side-effects; feeling that taking medicines is a burden and knowing enough about their medicines to decide whether to take them. Disease length did not relate to the responded barriers to non-adherence. Motivation- intention and ability to remember- to take medicines are important barriers to non-adherence. Conclusion There are several barriers to medicine adherence in the study population, indicating there is a need for interventions from healthcare professionals to improve adherence and increase the health of this patient group.Masteroppgave i FarmasiFARM399/05HMATF-FAR

Medicine Adherence & Augmented Reality

The purpose of this Exploratory is to scrutinise, develop and focus a project aiming to deliver multimedia information to the enquiring patient from trusted sources, using mobile phone based augmented reality technology to link this information to medicines, packaging, and pharmacy bags or support literature. This project ultimately aims to prove that such a platform would improve adherence behaviour

Beliefs about medicines and non-adherence in patients with stroke, diabetes mellitus and rheumatoid arthritis: a cross-sectional study in China

OBJECTIVES: To investigate beliefs about medicines and their association with medicine adherence in patients with chronic diseases in China. DESIGN: A cross-sectional questionnaire-based study SETTING: Two large urban hospitals in Hefei and Tianjin, China PARTICIPANTS: Hospital inpatients (313 stroke patients) and outpatients (315 diabetic patients and 339 rheumatoid arthritis (RA) patients) were recruited between January 2014 and September 2014. OUTCOME MEASURES: The Beliefs about Medicines Questionnaire (BMQ), assessing patients' beliefs about the specific medicine (Specific-Necessity and Specific-Concerns) prescribed for their conditions (stroke/diabetes/RA) and more general background beliefs about pharmaceuticals as a class of treatment (BMQ-General Benefit, Harm and Overuse); the Perceived Sensitivity to Medicines scale (PSM) assessed patients' beliefs about how sensitive they were to the effects of medicines and the Medication Adherence Report Scale. The association between non-adherence and beliefs about medicines was assessed using a logistic regression model. RESULTS: Patients with diabetes mellitus had a stronger perceived need for treatment (mean (SD) Specific-Necessity score, 3.75 (0.40)) than patients with stroke (3.69 (0.53)) and RA (3.66 (0.44)) (p=0.049). Moderate correlations were observed between Specific-Concerns and General-Overuse, General-Harm and PSM (Pearson correlation coefficients, 0.39, 0.49 and 0.49, respectively, p<0.01). Three hundred and eleven patients were non-adherent to their medicine (159 (51.0%) in the stroke group, 60 (26.7%) in the diabetes mellitus group and 62 (19.8%) in the RA group, p<0.01). Across the whole sample, after adjusting for demographic characteristics, non-adherence was associated with patients who had higher concerns about their medicines (OR, 1.35, 95% CI 1.07 to 1.71) and patients who believed that they were personally sensitive to the effects of medications (OR 1.44, 95% CI 1.16 to 1.85). CONCLUSION: The BMQ is a useful tool to identify patients at risk of non-adherence. In the future, adherence intervention studies may use the BMQ to screen for patients who are at risk of non-adherence and to map interventional support

Improvement medicine adherence on quality of life in hypertension patients

Hypertensive patients who do not take medication therapy for a long time will cause complications that will cause discomfort and affect their quality of life. This condition can be prevented and treated by having routine drug therapy. This study aims to determine the relationship between medication adherence and quality of life in hypertensive patients at the Mantrijeron Health Center, Yogyakarta. This research was a quantitative study using a cross-sectional design. The sample was taken using a purposive sampling technique with 74 respondents being hypertensive patients. The data collection instruments were the medication adherence report scale and the World Health Organization Quality of Life questionnaire. Bivariate analysis used the Pearson's correlation test which showed p = 0.027 (<0.05). These results indicate a significant relationship between medication adherence and the quality of life of hypertensive patients. The conclusion of this study is that there is a relationship between medication adherence and the quality of life of hypertensive patients. it is suggested that increasing medication adherence among hypertension patients can improve their quality of life

Medicine adherence and associated factors in immigrants and refugees:a systematic review

Medicine nonadherence is a major contributing factor to morbidity and mortality. Almost half of the chronically ill patients are nonadherent to their medication. Vulnerable groups like immigrants and refugees are at a higher risk of poor medication adherence. This study aims to determine the rate of medicine adherence and the factors associated with medicine nonadherence in a population of immigrants and refugees. A protocol-led (PROSPERO ID: CRD42021285419) systematic review was conducted by searching PubMed, Medline, Embase, Scopus, CINAHL, and Cochrane Library for studies published between 1st January 2000 and 4th November 2021. PRISMA guidelines were followed. The NIH quality assessment tool and CASP checklist were used to quality assess the papers. Data were searched, screened, and extracted. Extracted data were tabulated for descriptive and narrative analyses. 15 studies were conducted across six countries including participants with various medical conditions. The rate of medicine adherence reported ranged from 10.1% to 74.5%. Higher rates of nonadherence were observed in immigrants and refugees compared to migrant and native groups. Socio-economic factors, including language proficiency, level of education, and financial burden, and patient-related factors involving cultural behaviours and beliefs were common themes for nonadherence among immigrants and refugees. Further research is required to address the effect of nonadherence on clinical outcomes. Studies should focus on using a consistent definition of adherence and the same objective methods to measure rates of adherence to allow for meta-analysis of data and definitive results. Healthcare professionals (HCPs) are recommended to target interventions at improving adherence and reducing modifiable risk factors in immigrants and refugees, thus reducing health disparities among the population

Why don’t patients take their analgesics? A meta-ethnography assessing the perceptions of medication adherence in patients with osteoarthritis

Introduction/objectives: Whilst analgesics and medications have demonstrated efficacy for people with osteoarthritis, their effectiveness is dependent on adherence. This has previously been reported as particularly low in this population. The purpose of this meta-ethnography was to explore possible perceptions for this. Method: A systematic review of published and unpublished literature was undertaken. All qualitative studies assessing the attitudes or perceptions of people with osteoarthritis towards medication adherence were eligible. Study quality was assessed using the Critical Appraisal Skills Programme Qualitative tool. Analysis was undertaken using a meta-ethnography approach, distilling to a third order construct and developing a line of argument. Results: From 881 citations, five studies met the eligibility criteria. The meta-ethnography generated a model where medication adherence for people with osteoarthritis is perceived as a balance between the willingness or preference to take medications with the alterative being toleration of symptoms. Motivators to influence this ‘balance’ may fluctuate and change over time but include: severity of symptoms, education and understanding of osteoarthritis and current medications, or general health which may raise issues for poly-pharmacy as other medications are added or substituted into the patient’s formulary. Conclusions: Medicine adherence in people with osteoarthritis is complex, involving motivators which will fluctuate in impact on individuals at different points along the disease progression. Awareness of each motivator may better inform clinicians as to what education, support or change in prescription practice should be adopted to ensure that medicine adherence is individualised to better promote long-term behaviour change

The Correlation of Financial Models and Medicine Adherence in Patients With Diabetes Mellitus Inatalation of Outpatient at RSUD Ngudi Waluyo Wlingi

Hyperuricemia Medication adherence in patients with Diabetes Melitus is important in achieving treatment goals and effective in preventing some of the complications of Diabetes mellitus. Patients with chronical diseases such as Diabetes Mellitus whose treatment requires a long time even a lifetime to note about the social economy, especially how patients pay for treatment. The purpose of this study was to determine the correlation between financial models and medicine adherence in patients with diabetes mellitus of Outpatient in RSUD Ngudi Waluyo Wlingi. This study was a type of nonexperimental research design and analysis of cross sectional. This study was conducted in 68 patients with Tipe 2 Diabetes Mellitus at Outpatient RSUD Ngudi Waluyo Wlingi, in Nopember 2014, the samples were taken by accidental sampling technique. The correlation score of medication adherence with financial models was analized using Spearman Rank test. It was found that there were correlation between financial models and medicine adherence in patients with diabetes mellitus by p value 0,000. It was important to improve health education about medicine adherence and how to acces financing to support their trearments

Medicine Adherence as a Determinant of Complication Development in Diabetes and Hypertension Patients on a Medical Aid Scheme in Zimbabwe

Pharmacotherapy is a significant component of chronic disease management; its efficacy depends on long term, correct, and consistent use; however, medicine adherence rates remain low. The cost of medicines is considered a significant barrier to adherence, especially in low-income settings. This quantitative cross-sectional study was conducted using data from Cimas Medical Aid Society collected between 2015 and 2019. The purpose of the study was to determine the extent of the association between medicine adherence, complication development, and cost of care among diabetic and hypertensive patients while controlling for age and gender on a population that does not experience cost barriers to medicine access. The sample consisted of 23,303 diabetic and hypertensive patients above the age of 16 who purchased chronic medicines through medical aid. The chi-square test bivariate analysis showed a significant association between medicine adherence and complication development in hypertension (p \u3c 0.001) and no association in diabetic patients. Binary logistic regression indicated that nonadherent patients were more likely to develop hypertension complications (OR = 1.428, p \u3c 0.001) in females and older age groups. In diabetes patients, it showed no significant association between adherence and complication development (OR = 0.993, p = 0.841). The claims ratio was higher in nonadherent diabetes (OR = 8.301, p \u3c 0.001) and hypertensive (OR = 2.516, p \u3c 0.001) patients. The implications for positive social change include the findings being used to improve interventions for lowering non-cost barriers to medicine adherence, to reduce complication development, and lower the cost of care for diabetes and hypertension patients

Medicine Adherence as a Determinant of Complication Development in Diabetes and Hypertension Patients on a Medical Aid Scheme in Zimbabwe

Pharmacotherapy is a significant component of chronic disease management; its efficacy depends on long term, correct, and consistent use; however, medicine adherence rates remain low. The cost of medicines is considered a significant barrier to adherence, especially in low-income settings. This quantitative cross-sectional study was conducted using data from Cimas Medical Aid Society collected between 2015 and 2019. The purpose of the study was to determine the extent of the association between medicine adherence, complication development, and cost of care among diabetic and hypertensive patients while controlling for age and gender on a population that does not experience cost barriers to medicine access. The sample consisted of 23,303 diabetic and hypertensive patients above the age of 16 who purchased chronic medicines through medical aid. The chi-square test bivariate analysis showed a significant association between medicine adherence and complication development in hypertension (p \u3c 0.001) and no association in diabetic patients. Binary logistic regression indicated that nonadherent patients were more likely to develop hypertension complications (OR = 1.428, p \u3c 0.001) in females and older age groups. In diabetes patients, it showed no significant association between adherence and complication development (OR = 0.993, p = 0.841). The claims ratio was higher in nonadherent diabetes (OR = 8.301, p \u3c 0.001) and hypertensive (OR = 2.516, p \u3c 0.001) patients. The implications for positive social change include the findings being used to improve interventions for lowering non-cost barriers to medicine adherence, to reduce complication development, and lower the cost of care for diabetes and hypertension patients