709 research outputs found
In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients
The present study was performed to investigate the capability of gemcitabine and pemetrexed to synergistically interact with respect to cytotoxicity and apoptosis in T24 and J82 bladder cancer cells, and to establish a correlation between drug activity and gene expression of selected genes in tumour samples. The interaction between gemcitabine and pemetrexed was synergistic; indeed, pemetrexed favoured gemcitabine cytotoxicity by increasing cellular population in S-phase, reducing Akt phosphorylation as well as by inducing the expression of a major gemcitabine uptake system, the human equilibrative nucleoside transporter-1 (hENT1), and the key activating enzyme deoxycytidine kinase (dCK) in both cell lines. Bladder tumour specimens showed an heterogeneous gene expression pattern and patients with higher levels of dCK and hENT1 had better response. Moreover, human nucleoside concentrative transporter-1 was detectable only in 3/12 patients, two of whom presented a complete response to gemcitabine. These data provide evidence that the chemotherapeutic activity of the combination of gemcitabine and pemetrexed is synergistic against bladder cancer cells in vitro and that the assessment of the expression of genes involved in gemcitabine uptake and activation might be a possible determinant of bladder cancer response and may represent a new tool for treatment optimization
Inclusive Search for Anomalous Production of High-pT Like-Sign Lepton Pairs in Proton-Antiproton Collisions at sqrt{s}=1.8 TeV
We report on a search for anomalous production of events with at least two
charged, isolated, like-sign leptons with pT > 11 GeV/c using a 107 pb^-1
sample of 1.8 TeV ppbar collisions collected by the CDF detector. We define a
signal region containing low background from Standard Model processes. To avoid
bias, we fix the final cuts before examining the event yield in the signal
region using control regions to test the Monte Carlo predictions. We observe no
events in the signal region, consistent with an expectation of
0.63^(+0.84)_(-0.07) events. We present 95% confidence level limits on new
physics processes in both a signature-based context as well as within a
representative minimal supergravity (tanbeta = 3) model.Comment: 15 pages, 4 figures. Minor textual changes, cosmetic improvements to
figures and updated and expanded reference
Search for Kaluza-Klein Graviton Emission in Collisions at TeV using the Missing Energy Signature
We report on a search for direct Kaluza-Klein graviton production in a data
sample of 84 of \ppb collisions at = 1.8 TeV, recorded
by the Collider Detector at Fermilab. We investigate the final state of large
missing transverse energy and one or two high energy jets. We compare the data
with the predictions from a -dimensional Kaluza-Klein scenario in which
gravity becomes strong at the TeV scale. At 95% confidence level (C.L.) for
=2, 4, and 6 we exclude an effective Planck scale below 1.0, 0.77, and 0.71
TeV, respectively.Comment: Submitted to PRL, 7 pages 4 figures/Revision includes 5 figure
Measurement of the average time-integrated mixing probability of b-flavored hadrons produced at the Tevatron
We have measured the number of like-sign (LS) and opposite-sign (OS) lepton
pairs arising from double semileptonic decays of and -hadrons,
pair-produced at the Fermilab Tevatron collider. The data samples were
collected with the Collider Detector at Fermilab (CDF) during the 1992-1995
collider run by triggering on the existence of and candidates
in an event. The observed ratio of LS to OS dileptons leads to a measurement of
the average time-integrated mixing probability of all produced -flavored
hadrons which decay weakly, (stat.)
(syst.), that is significantly larger than the world average .Comment: 47 pages, 10 figures, 15 tables Submitted to Phys. Rev.
Search for Charginos with a Small Mass Difference with the Lightest Supersymmetric Particle at \sqrt{s} = 189 GeV
A search for charginos nearly mass-degenerate with the lightest
supersymmetric particle is performed using the 176 pb^-1 of data collected at
189 GeV in 1998 with the L3 detector. Mass differences between the chargino and
the lightest supersymmetric particle below 4 GeV are considered. The presence
of a high transverse momentum photon is required to single out the signal from
the photon-photon interaction background. No evidence for charginos is found
and upper limits on the cross section for chargino pair production are set. For
the first time, in the case of heavy scalar leptons, chargino mass limits are
obtained for any \tilde{\chi}^{+-}_1 - \tilde{\chi}^0_1 mass difference
Study of Z Boson Pair Production in e+e- Collisions at LEP at \sqrt{s}=189 GeV
The pair production of Z bosons is studied using the data collected by the L3
detector at LEP in 1998 in e+e- collisions at a centre-of-mass energy of 189
GeV. All the visible final states are considered and the cross section of this
process is measured to be 0.74 +0.15 -0.14 (stat.) +/- 0.04 (syst.) pb. Final
states containing b quarks are enhanced by a dedicated selection and their
production cross section is found to be 0.18 +0.09 -0.07 (stat.) +/- 0.02
(syst.) pb. Both results are in agreement with the Standard Model predictions.
Limits on anomalous couplings between neutral gauge bosons are derived from
these measurements
Production of Single W Bosons at \sqrt{s}=189 GeV and Measurement of WWgamma Gauge Couplings
Single W boson production in electron-positron collisions is studied with the
L3 detector at LEP. The data sample collected at a centre-of-mass energy of
\sqrt{s} = 188.7GeV corresponds to an integrated luminosity of 176.4pb^-1.
Events with a single energetic lepton or two acoplanar hadronic jets are
selected. Within phase-space cuts, the total cross-section is measured to be
0.53 +/- 0.12 +/- 0.03 pb, consistent with the Standard Model expectation.
Including our single W boson results obtained at lower \sqrt{s}, the WWgamma
gauge couplings kappa_gamma and lambda_gamma are determined to be kappa_gamma =
0.93 +/- 0.16 +/- 0.09 and lambda_gamma = -0.31 +0.68 -0.19 +/- 0.13
Measurement of the W+W-gamma Cross Section and Direct Limits on Anomalous Quartic Gauge Boson Couplings at LEP
The process e+e- -> W+W-gamma is analysed using the data collected with the
L3 detector at LEP at a centre-of-mass energy of 188.6GeV, corresponding to an
integrated luminosity of 176.8pb^-1. Based on a sample of 42 selected W+W-
candidates containing an isolated hard photon, the W+W-gamma cross section,
defined within phase-space cuts, is measured to be: sigma_WWgamma = 290 +/- 80
+/- 16 fb, consistent with the Standard Model expectation. Including the
process e+e- -> nu nu gamma gamma, limits are derived on anomalous
contributions to the Standard Model quartic vertices W+W- gamma gamma and W+W-Z
gamma at 95% CL: -0.043 GeV^-2 < a_0/Lambda^2 < 0.043 GeV^-2 0.08 GeV^-2 <
a_c/Lambda^2 < 0.13 GeV^-2 0.41 GeV^-2 < a_n/Lambda^2 < 0.37 GeV^-2
Search for Low Scale Gravity Effects in e+e- Collisions at LEP
Recent theories propose that quantum gravity effects may be observable at LEP
energies via gravitons that couple to Standard Model particles and propagate
into extra spatial dimensions. The associated production of a graviton and a
photon is searched for as well as the effects of virtual graviton exchange in
the processes: e+e- -> gamma gamma, ZZ, WW, mu mu, tau tau, qq and ee No
evidence for this new interaction is found in the data sample collected by the
L3 detector at LEP at centre-of-mass energies up to 183 GeV. Limits close to 1
TeV on the scale of this new scenario of quantum gravity are set
Study of Z Boson Pair Production in e^+e^- Interactions at \sqrt{s}=192 - 202 GeV
The cross section for the production of Z boson pairs is measured using the
data collected by the L3 detector at LEP in 1999 in e^+e^- collisions at
centre-of-mass energies ranging from 192 GeV up to 202 GeV. Events in all the
visible final states are selected, measuring the cross section of this process.
The special case of final states containing b quarks is also investigated. All
results are in agreement with the Standard Model predictions
- …