Fatherhood and sperm DNA damage in testicular cancer patients

Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility. Survivors must overcome anxiety and fears about reduced fertility and possible pregnancy-related risks as well as health effects in offspring. There is thus a growing awareness of the need for reproductive counseling of cancer survivors. Studies found a high level of sperm DNA damage in TC patients in comparison with healthy, fertile controls, but no significant difference between these patients and infertile patients. Sperm DNA alterations due to cancer treatment persist from 2 to 5 years after the end of the treatment and may be influenced by both the type of therapy and the stage of the disease. Population studies reported a slightly reduced overall fertility of TC survivors and a more frequent use of ART than the general population, with a success rate of around 50%. Paternity after a diagnosis of cancer is an important issue and reproductive potential is becoming a major quality of life factor. Sperm chromatin instability associated with genome instability is the most important reproductive side effect related to the malignancy or its treatment. Studies investigating the magnitude of this damage could have a considerable translational importance in the management of cancer patients, as they could identify the time needed for the germ cell line to repair nuclear damage and thus produce gametes with a reduced risk for the offspring

Logic and groups

Abelian group logic (AGL) — in other words, the logic which is sound and complete w.r.t. Abelian groups — is a non-trivial inconsistent logic, i.e. what some paraconsistent logicians call a “dialethic” logic

An Abstract Approach to Consequence Relations

We generalise the Blok-J\'onsson account of structural consequence relations, later developed by Galatos, Tsinakis and other authors, in such a way as to naturally accommodate multiset consequence. While Blok and J\'onsson admit, in place of sheer formulas, a wider range of syntactic units to be manipulated in deductions (including sequents or equations), these objects are invariably aggregated via set-theoretical union. Our approach is more general in that non-idempotent forms of premiss and conclusion aggregation, including multiset sum and fuzzy set union, are considered. In their abstract form, thus, deductive relations are defined as additional compatible preorderings over certain partially ordered monoids. We investigate these relations using categorical methods, and provide analogues of the main results obtained in the general theory of consequence relations. Then we focus on the driving example of multiset deductive relations, providing variations of the methods of matrix semantics and Hilbert systems in Abstract Algebraic Logic

Relating Logic and Relating Semantics. History, Philosophical Applications and Some of Technical Problems

Here, we discuss historical, philosophical and technical problems associated with relating logic and relating semantics. To do so, we proceed in three steps. First, Section 1 is devoted to providing an introduction to both relating logic and relating semantics. Second, we address the history of relating semantics and some of the main research directions and their philosophical applications. Third, we discuss some technical problems related to relating semantics, particularly whether the direct incorporation of the relation into the language of relating logic is needed. The starting point for our considerations presented here is the 1st Workshop On Relating Logic and the selected papers for this issue.KKKKKKKK

Applications of Relating Semantics: From non-classical logics to philosophy of science

Here, we discuss logical, philosophical and technical problems associated to relating logic and relating semantics. To do so, we proceed in three steps. The first step is devoted to providing an introduction to both relating logic and relating semantics. We discuss this problem on the example of different languages. Second, we address some of the main research directions and their philosophical applications to non-classical logics, particularly to connexive logics. Third, we discuss some technical problems related to relating semantics, and its application to philosophy of science, language and pragmatics

Guest editors’ introduction

A logic is said to be paraconsistent if it doesn’t license you to infer everything from a contradiction. To be precise, let |= be a relation of logical consequence. We call |= explosive if it validates the inference rule: {A,¬A} |= B for every A and B. Classical logic and most other standard logics, including intuitionist logic, are explosive. Instead of licensing you to infer everything from a contradiction, paraconsistent logic allows you to sensibly deal with the contradiction

On some properties of quasi-MV algebras and square root quasi-MV algebras, IV

In the present paper, which is a sequel to [20, 4, 12], we investigate further the structure theory of quasiMV algebras and √0quasi-MV algebras. In particular: we provide a new representation of arbitrary √0qMV algebras in terms of √0qMV algebras arising out of their MV* term subreducts of regular elements; we investigate in greater detail the structure of the lattice of √0qMV varieties, proving that it is uncountable, providing equational bases for some of its members, as well as analysing a number of slices of special interest; we show that the variety of √0qMV algebras has the amalgamation property; we provide an axiomatisation of the 1-assertional logic of √0qMV algebras; lastly, we reconsider the correspondence between Cartesian √0qMV algebras and a category of Abelian lattice-ordered groups with operators first addressed in [10]