5 research outputs found
SĂ©verine Bortot, Dominique Michelet, VĂ©ronique Darras (editores). "Almacenamiento prehispĂĄnico del Norte de MĂ©xico al Altiplano Central"
Salvador Bernabéu, Christophe Giudicelli y Gilles Havard (coords.): "La indianización. Cautivos, renegados, «hommes libres» y prisioneros en los confines americanos S. XVI-XIX"
Juan JosĂ© Batalla Rosado y Miguel Ăngel Ruz Barrio (coords.): "CĂłdices del Centro de MĂ©xico. AnĂĄlisis comparativos y estudios individuales"
A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies