El discurso sobre género en la página de Facebook del Movimiento Pro Vida y Pro Familia en Paraguay

Desde la perspectiva del Análisis Crítico del Discurso (ACD) y con la aplicación de la Teoría Fundamentada, el presente artículo busca identificar los componentes constitutivos del discurso del movimiento “Pro Familia” en Paraguay, el cual enaltece a la familia nuclear y heteronormativa, presentándola como el modelo tradicional único aceptable. Para ello se desarrolla un análisis descriptivo y relacional de las estrategias discursivas contenidas en los vídeos publicados en la página de Facebook “Somos muchos, muchos más” del Movimiento Frente Pro Vida y Pro Familia Paraguay, entre los meses de julio y agosto del 2017. A partir de la reconstrucción inductiva de categorías generales, de elementos particulares y de contenidos compartidos entre los interlocutores, se pudo constatar que este movimiento presenta un discurso ideológico, con criterios más bien religiosos y tradicionalistas, y que en su lucha por la hegemonía utiliza como principales recursos el miedo y la representación negativa de sus “rivales”

Herramientas Digitales en el proceso de enseñanza aprendizaje en la asignatura de Emprendimiento y Gestión

The use of digital tools is no longer a fashion or a privilege, but a necessity in a world that needs optimal and quality results; This is more noticeable in education, in the teaching-learning processes of all subjects, specifically in the field of entrepreneurship, which is a strategy for the development of skills in students, in the future, they can create their own business. Precisely, the objective of this article was to elaborate a methodological guide on the knowledge and use of a digital tool to strengthen the teaching-learning process of the Entrepreneurship and Management subject in students of the third year of technical baccalaureate of the Educational Unit "Picoazá ”; for which it is developed on the theoretical foundation and proposes a methodological guide using the digital isEazy Author, to strengthen the teaching-learning process of the subject of entrepreneurship and management in the third-year students of the technical baccalaureate of the aforementioned educational institution. Methodologically, it was applied in a quantitative approach, deductive method, with the survey technique, applied to the sample that was made up of teachers and students; concluding that the level of learning of the subject of entrepreneurship and management by the students is acceptable, one of the causes being little use of digital tools, for which it is necessary to implement a methodological guide using the digital tool isEazy Author , which will strengthen said learning.La utilización de las herramientas digitales ya no es una moda o un privilegio, sino una necesidad en un mundo que necesita resultados óptimos y de calidad; esto es más notorio en educación, en los procesos de enseñanza aprendizaje de todas las asignaturas, específicamente en materia de emprendimiento que es una estrategia para el desarrollo de competencias en los estudiantes, a futuro, puedan crear su propio negocio. Precisamente el presente articulo tuvo como objetivo el de elaborar una guía metodológica en el conocimiento y uso de una herramienta digital para fortalecer el proceso enseñanza aprendizaje de la asignatura de Emprendimiento y Gestión en los estudiantes del tercer año de bachillerato técnico de la Unidad Educativa “Picoazá”; para lo cual se desarrolla en la fundamentación teórica y propone una guía metodológica utilizando la digital isEazy Author, para fortalecer el proceso enseñanza aprendizaje de la asignatura de emprendimiento y gestión en los estudiantes de tercero de bachillerato técnico de la institución educativa ya señalada. Metodológicamente se aplicó en enfoque cuantitativo, método deductivo, con la técnica de la encuesta, aplicada a la muestra que estuvo conformada por docentes y estudiantes; concluyendo que el nivel de aprendizaje de la asignatura de emprendimiento y gestión por parte de los estudiantes es aceptable, siendo una de la causas poca utilización de las herramientas digitales, por lo que se hace necesario la implementación de una guía metodológica utilizando herramienta digital isEazy Author, que fortalecerá dicho aprendizaje

Effect of high-intensity interval versus continuous exercise training on functional capacity and quality of life in patients with coronary artery disease.

There is strong evidence that exercise training has beneficial health effects in patients with cardiovascular disease. Most studies have focused on moderate continuous training (MCT); however, a body of evidence has begun to emerge demonstrating that highintensity interval training (HIIT) has significantly better results in terms of morbidity and mortality. The aim of this study was to compare the effects of MCT versus HIIT on functional capacity and quality of life and to assess safety. Seventy-two patients with ischemic heart disease were assigned to either HITT or MCT for 8 weeks. We analyzed cardiopulmonary exercise stress test data, quality of life, and adverse events.High-intensity interval training resulted in a significantly greater increase in V · O 2 peak (4.5 ± 4.7 mL·kg − 1 ·min − 1 ) compared with MCT (2.5 ± 3.6 mL·kg − 1 ·min − 1 ) ( P < .05). The aerobic threshold (V T 1 ) increased by 21% in HIIT and 14% in MCT. Furthermore, there was a significant ( P < .05) increase in the distance covered in the 6-minute walk distance test in the HIIT group (49.6 ± 6.3 m) when compared with the MCT group (29.6 ± 12.0 m). Both training protocols improved quality of life. No adverse events were reported in either of the groups.On the basis of the results of this study, HIIT should be considered for use in cardiac rehabilitation as it resulted in a greater increase in functional capacity compared with MCT. We also observed greater improvement in quality of life without any increase in cardiovascular risk.post-print377 K

Business Consulting Luker Chocolate

Luker Chocolate es una unidad de negocio de la empresa CasaLuker que comenzó su proceso de internacionalización hace diez años con el objetivo de posicionar el cacao fino de aroma colombiano y de impactar positivamente a las comunidades cacaoteras fomentando el desarrollo agrícola del país. Esta consultoría tuvo como objetivo la identificación de los problemas que enfrenta Luker Chocolate para así explotar la oportunidad de negocio más conveniente para la compañía y de esta forma proponer una solución que permita continuar con su plan de crecimiento sostenible. Dentro de los hallazgos encontrados se observó una alta dependencia de los mercados de Estados Unidos y de Europa, haciendo evidente la necesidad de desarrollar planes concretos de expansión a nuevos mercados internacionales, específicamente al mercado asiático. El conocimiento de la compañía sobre la región de Asia es mínimo, debido a que su acercamiento ha sido netamente reactivo, razón por la cual se realizó una investigación de mercado con fuentes secundarias con el propósito de identificar cuál de los países evaluados sería el más recomendable para hacer el ingreso, así como a que canal se debe ingresar. De esta forma, se identifica a China como el país con mayores probabilidades de éxito y se selecciona a Shanghái como ciudad para comenzar la expansión como mercado piloto desarrollando la estrategia comercial y de mercadeo bajo el modelo del marketing mix. La evaluación financiera del proyecto se realizó contemplando tres escenarios. El pesimista no es atractivo en el corto y mediano plazo, sin embargo, con el medio y el optimista se logra punto de equilibrio en el tercer y segundo año respectivamente y al finalizar el sexto año, para el escenario medio, se lograría un valor presente neto de $2,457 millones de pesos Colombianos con una tasa interna de retorno del 32.2$5,991 millones de pesos colombianos con una tasa interna de retorno del 66.8%, haciendo el proyecto viable.Luker Chocolate is a Business unit of CasaLuker company that began its internationalization process ten years ago with the aim of positioning Colombian fine flavor cocoa and with the commitment to impact positively the cocoa communities where they work by promoting the country's agricultural development. The objective of this consultancy was to identify the problems faced by Luker Chocolate in order to identify the most convenient business opportunity for the company and thus propose a solution that allows it to continue with its sustainable growth plan. Among the findings found, a high dependence on the markets of the United States and Europe was observed, making evident the need to develop concrete expansion plans to new international markets, specifically the Asian market. The company's knowledge of the Asian region is minimal, because its approach has been clearly reactive, which is why a market research was carried out with secondary sources in order to identify which of the evaluated countries would be the most recommended for make the entry, as well as which channel to enter. In this way, China was identified as the country with the greatest probability of success and Shanghai is selected as the city to begin the expansion as a pilot market, developing the commercial and marketing strategy under the marketing mix model. The financial assessment of the project was carried out considering three scenarios. The pessimistic is not attractive in the short and medium term, however with the medium and the optimistic one breakeven is achieved in the third and second year respectively and at the end of the sixth year for the medium scenario a net present value of $2,457 million Colombia pesos would be achieved. with an internal rate of return of 32.2$5,991 million would be achieved with an internal rate of return of 66.8%, making the project feasible

Statin use and the risk of colorectal cancer in a population-based electronic health records study

There is extensive debate regarding the protective effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on colorectal cancer (CRC). We aimed to assess the association between CRC risk and exposure to statins using a large cohort with prescription data. We carried out a case-control study in Catalonia using the System for Development of Primary Care Research (SIDIAP) database that recorded patient diseases history and linked data on reimbursed medication. The study included 25 811 cases with an incident diagnosis of CRC between 2010 and 2015 and 129 117 frequency-matched controls. Subjects were classified as exposed to statins if they had ever been dispensed statins. Analysis considering mean daily defined dose, cumulative duration and type of statin were performed. Overall, 66 372 subjects (43%) were exposed to statins. There was no significant decrease of CRC risk associated to any statin exposure (OR = 0.98; 95% CI: 0.95-1.01). Only in the stratified analysis by location a reduction of risk for rectal cancer was observed associated to statin exposure (OR = 0.87; 95% CI: 0.81-0.92). This study does not support an overall protective effect of statins in CRC, but a protective association with rectal cancer merits further research

Statin use and the risk of colorectal cancer in a population-based electronic health records study

There is extensive debate regarding the protective effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on colorectal cancer (CRC). We aimed to assess the association between CRC risk and exposure to statins using a large cohort with prescription data. We carried out a case-control study in Catalonia using the System for Development of Primary Care Research (SIDIAP) database that recorded patient diseases history and linked data on reimbursed medication. The study included 25 811 cases with an incident diagnosis of CRC between 2010 and 2015 and 129 117 frequency-matched controls. Subjects were classified as exposed to statins if they had ever been dispensed statins. Analysis considering mean daily defined dose, cumulative duration and type of statin were performed. Overall, 66 372 subjects (43%) were exposed to statins. There was no significant decrease of CRC risk associated to any statin exposure (OR = 0.98; 95% CI: 0.95-1.01). Only in the stratified analysis by location a reduction of risk for rectal cancer was observed associated to statin exposure (OR = 0.87; 95% CI: 0.81-0.92). This study does not support an overall protective effect of statins in CRC, but a protective association with rectal cancer merits further research

Preeclampsia severa de aparición temprana: características clínico epidemiológicas en la unidad de cuidados intensivos materno del INMP agosto del 2014 a setiembre del 2018

Objective: to acknowledge the pathological, clinical and epidemiological characteristics of early-onset severe preeclampsia and late-onset severe preeclampsia in patients admitted in the maternal intensive care unit (MICU) of the maternal perinatal national institute (INMP). Methods: We develop a comparative transversal descriptive study. Clinical charts were reviewed from August first of 2014 until September thirty of 2018 getting 332 charts of early-onset preeclampsia and 325 charts of the late-onset type. Results: The mean age of the patients with early-onset severe preeclampsia was 27.84 years (IC 26.88- 28.81) (p: 0.72), the mean for hospital stay was higher in the patients with the early-onset type (p: 0.006). The new born showed statistical difference in weight (p=0.000), height (p=0.000) and the APGAR score was lower in the early-onset group (p=0.000). We did not found difference statistically significative between early-onset severe preeclampsia and eclampsia (p=0.481). Conclusion: we did not found differences between early onset preeclampsia and eclampsia. New born had lower weight, height and APGAR score in the early-onset group than in the late-onset group.Objetivo: conocer las características epidemiológicas clínicas y patológicas de la Preeclampsia severa (PES) de aparición temprana y la PES de aparición tardía de pacientes admitidas a la Unidad de Cuidados Intensivos Maternos (UCIM) del Instituto Nacional Materno Perinatal (INMP). Material y métodos: se realizó un estudio descriptivo transversal comparativo en el que se revisaron las historias clínicas desde EL primero de agosto del 2014 hasta el 30 de Setiembre del 2018 obteniendo 332 registros de pacientes con PES de aparición Temprana y 325 registros de pacientes con PES de aparición tardía.Resultados: La edad promedio de las pacientes con diagnóstico de PES de aparición temprana fue 27.84 años [IC 26.88- 28.81 (p: 0.72)], el promedio de estancia hospitalaria fue mayor en las pacientes con PES de aparición temprana (p 0.006). Los recién nacidos mostraron diferencias significativas con respecto al peso (p= 0.000), la talla (p= 0.000); el APGAR al minuto fue significativamente menor en el grupo de aparición temprana (p=0.000). No se encuentra diferencia significativa entre la PES de aparición temprana y la eclampsia (p=0.481). Conclusión: No observamos diferencias significativas entre PES de aparición temprana y eclampsia. Los recién nacidos, presentan peso, talla y APGAR menores en el grupo de aparición temprana que el grupo de aparición tardía

Mujeres en la arqueología de Mendoza: Pioneras, silencios y nuevas voces

This preliminary article arose from the interest of a group of women archaeologists from different parts of the Province of Mendoza (Argentina) who met with the aim of generating a new perspective on the place of women in the local history of the discipline. This vision, based on their own accounts, makes it possible to highlight, rethink, and question this history and clarify the current situation. To address this issue, we worked on three areas of analysis. The first focuses on recognizing the trajectories of women pioneers and finding evidence of them in the history of archaeology in Mendoza. The second area analyzes the professional disparity between men and women within the discipline. The third area investigates the types of violence in the professional and academic environment. The results show the historical invisibility of pioneer women archaeologists in the province between the 1940s and 1970s. It was also possible to recognize the disparity and professional segregation between women and men in the field of teaching and research, where women achieve less progress in professional careers. Finally, we describe concrete actions of gender violence experienced by women archaeologists today, which reveals the internalization of the mechanisms of patriarchal coercion within the academic system.  Este trabajo, de carácter preliminar, surgió del interés de un grupo de arqueólogas de diferentes regiones de la Provincia de Mendoza (Argentina) reunidas con el objetivo de generar una nueva mirada acerca del lugar de las mujeres en la historia local de la disciplina. Esta visión basada en relatos propios permitió evidenciar, repensar y cuestionar esta historia y seguidamente exponer la situación actual. Para abordar esta problemática se trabajó en el análisis de tres ejes. El primero, se centró en reconocer las trayectorias de las pioneras y evidenciar su presencia en la historia de la arqueología en Mendoza; el segundo eje analizó la existencia de disparidad profesional entre varones y mujeres dentro de la disciplina; el tercero indagó sobre los tipos de violencia ejercida en el ámbito profesional y académico. Los resultados demuestran la invisibilización histórica que han tenido las mujeres pioneras de la disciplina en la provincia entre las décadas de 1940 y 1970. También pudo reconocerse la disparidad y segregación profesional entre mujeres y varones en el ámbito de la docencia y la investigación, en la que las mujeres logran menores avances en la carrera profesional. Por último, se pusieron de manifiesto las acciones concretas de violencia de género experimentadas por las arqueólogas en la actualidad, que dan cuenta de la interiorización de los mecanismos de coerción del patriarcado dentro del sistema académico.

Clinical Presentation, Management, and Evolution of Lymphomas in Patients with Inflammatory Bowel Disease: An ENEIDA Registry Study

Simple Summary An increased risk of hematological malignancies, mainly lymphomas, has been described in patients with inflammatory bowel disease (IBD). Because there are scarce data about the management and evolution of lymphomas in patients with IBD, the aim of our study was to analyze these points in those patients with IBD and lymphoma diagnosis included in the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD). We found that most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies. The five-year survival rate was 85% for non-Hodgkin lymphoma and 84% in patients with Hodgkin lymphoma. An increased risk of lymphoma has been described in patients with inflammatory bowel disease (IBD). The aims of our study were to determine the clinical presentation, the previous exposure to immunosuppressive and biologic therapies, and the evolution of lymphomas in patients with IBD. IBD patients with diagnosis of lymphoma from October 2006 to June 2021 were identified from the prospectively maintained ENEIDA registry of GETECCU. We identified 52 patients (2.4 cases of lymphoma/1000 patients with IBD; 95% CI 1.8-3.1). Thirty-five were men (67%), 52% had ulcerative colitis, 60% received thiopurines, and 38% an anti-TNF drug before lymphoma diagnosis. Age at lymphoma was lower in those patients treated with thiopurines (53 +/- 17 years old) and anti-TNF drugs (47 +/- 17) than in those patients not treated with these drugs (63 +/- 12; p < 0.05). Five cases had relapse of lymphoma (1.7 cases/100 patient-years). Nine patients (17%) died after 19 months (IQR 0-48 months). Relapse and mortality were not related with the type of IBD or lymphoma, nor with thiopurines or biologic therapies. In conclusion, most IBD patients had been treated with thiopurines and/or anti-TNF agents before lymphoma diagnosis, and these patients were younger at diagnosis of lymphoma than those not treated with these drugs. Relapse and mortality of lymphoma were not related with these therapies

A Precision Treatment Model for Internet-Delivered Cognitive Behavioral Therapy for Anxiety and Depression among University Students:A Secondary Analysis of a Randomized Clinical Trial

Importance: Guided internet-delivered cognitive behavioral therapy (i-CBT) is a low-cost way to address high unmet need for anxiety and depression treatment. Scalability could be increased if some patients were helped as much by self-guided i-CBT as guided i-CBT. Objective: To develop an individualized treatment rule using machine learning methods for guided i-CBT vs self-guided i-CBT based on a rich set of baseline predictors. Design, Setting, and Participants: This prespecified secondary analysis of an assessor-blinded, multisite randomized clinical trial of guided i-CBT, self-guided i-CBT, and treatment as usual included students in Colombia and Mexico who were seeking treatment for anxiety (defined as a 7-item Generalized Anxiety Disorder [GAD-7] score of ≥10) and/or depression (defined as a 9-item Patient Health Questionnaire [PHQ-9] score of ≥10). Study recruitment was from March 1 to October 26, 2021. Initial data analysis was conducted from May 23 to October 26, 2022. Interventions: Participants were randomized to a culturally adapted transdiagnostic i-CBT that was guided (n = 445), self-guided (n = 439), or treatment as usual (n = 435). Main Outcomes and Measures: Remission of anxiety (GAD-7 scores of ≤4) and depression (PHQ-9 scores of ≤4) 3 months after baseline. Results: The study included 1319 participants (mean [SD] age, 21.4 [3.2] years; 1038 women [78.7%]; 725 participants [55.0%] came from Mexico). A total of 1210 participants (91.7%) had significantly higher mean (SE) probabilities of joint remission of anxiety and depression with guided i-CBT (51.8% [3.0%]) than with self-guided i-CBT (37.8% [3.0%]; P =.003) or treatment as usual (40.0% [2.7%]; P =.001). The remaining 109 participants (8.3%) had low mean (SE) probabilities of joint remission of anxiety and depression across all groups (guided i-CBT: 24.5% [9.1%]; P =.007; self-guided i-CBT: 25.4% [8.8%]; P =.004; treatment as usual: 31.0% [9.4%]; P =.001). All participants with baseline anxiety had nonsignificantly higher mean (SE) probabilities of anxiety remission with guided i-CBT (62.7% [5.9%]) than the other 2 groups (self-guided i-CBT: 50.2% [6.2%]; P =.14; treatment as usual: 53.0% [6.0%]; P =.25). A total of 841 of 1177 participants (71.5%) with baseline depression had significantly higher mean (SE) probabilities of depression remission with guided i-CBT (61.5% [3.6%]) than the other 2 groups (self-guided i-CBT: 44.3% [3.7%]; P =.001; treatment as usual: 41.8% [3.2%]; P &lt;.001). The other 336 participants (28.5%) with baseline depression had nonsignificantly higher mean (SE) probabilities of depression remission with self-guided i-CBT (54.4% [6.0%]) than guided i-CBT (39.8% [5.4%]; P =.07). Conclusions and Relevance: Guided i-CBT yielded the highest probabilities of remission of anxiety and depression for most participants; however, these differences were nonsignificant for anxiety. Some participants had the highest probabilities of remission of depression with self-guided i-CBT. Information about this variation could be used to optimize allocation of guided and self-guided i-CBT in resource-constrained settings. Trial Registration: ClinicalTrials.gov Identifier: NCT04780542.</p