Pachyonychia congenita type I with severe oral leukokeratosis

Pachyonychia Congenita (PC) is a rare autosomal dominant keratin disorder that affects a number of ectodermal structures including the nails and palmoplantar skin, and often involves the oral mucosa, tongue, larynx, teeth and hair. Clinical features are usually present at birth or early infancy. There are two main subtypes of PC. Fingernail thickening and oral keratosis are more common and severe in PC-1 and cystic lesions, hair abnormalities, natal teeth and pili torti are more common in PC-2. We report the case of a 6-year-old boy with PC-1 presenting with severe and painful oral leukokeratosis and extensive caries

Changes in some physico-chemical content of Anatolian buffalo milk according to the some environmental factors

The aim of this study was to determine the some physico-chemical content of raw milk from Anatolian water buffaloes raised under different village conditions in the Tokat province of Northern Turkey. The study materials included 1272 milk samples from 149 water buffaloes raised at 12 separate villages of the Erbaa, Turhal, and Pazar counties in the Tokat Province. Milk samples were collected during the morning milking between the months of February and May 2012 to 2014. The density, freezing point degree, dry matter, nonfat dry matter (or solid non fat), fat, protein, lactose, milk urea nitrogen and casein content of the milk samples were determined. The study results demonstrated that the mean dry matter, nonfat dry matter, fat, protein, lactose, casein content, density, milk urea nitrogen (MUN) and freezing point degree (FPD) of the raw milk samples were 16.99±0.108%, 10.88±0.036%, 5.98±0.107%, 4.85±0.043%, 5.17±0.021%, 3.61±0.036%, 1029±0.056, 21, 22 mg/dl and 0.55°C, respectively. The study data were evaluated according to the water buffaloes’ lactation stage, parity, and season by using the SPSS statistical program. It was concluded that the sampling time, parity, village conditions, stage of lactation and calving age had a significant effect (P<0.05) on the density, freezing point degree, dry matter, nonfat dry matter, fat, protein, lactose, and casein content of raw milk from the Anatolian water buffalo. © 2016, Kasetsart University. All rights reserved.TAGEM/60MANDA2011-01 --This investigation was supported by Republic of Turkey Ministry of Food, Agriculture and Livestock, General Directorate of Agricultural Research and Policies for financial support (TAGEM/60MANDA2011-01). -

Preservice elementary teachers’ perceptions of their self-efficacy in teaching thinking skills

AbstractPreservice teachers’ self-efficacy in teaching the thinking skills included in the curriculum is important to the achievement of objectives. What are the self-efficacy levels of preservice teachers in teaching thinking skills? The present study aims to determine the self-efficacy of preservice teachers in this area. The study is of a descriptive nature and uses the survey model. The study sample consists of a total of 263 third and fourth-year students from Marmara University, Atatürk Education Faculty, Elementary Teacher Education Department. The scale used in the study had been developed for Tebbs’ PhD dissertation entitled “Assessing Teachers’ Self-Efficacy towards Teaching Thinking Skills” and was adapted into Turkish by Kaya (2008). The data were analyzed by using arithmetic means, standard deviation, independent samples t- test, analysis of variance, and Pearson product-moment correlation analysis

[N-(2-Hydroxy­ethyl)ethyl­enediamine]oxalatocopper(II)

In the title mononuclear copper(II) compound, [Cu(C2O4)(C4H12N2O)], the CuII ion has a slightly distorted square-pyramidal geometry, with a tridentate N-(2-hydroxy­ethyl)ethyl­enediamine (HydEt-en) and a bidentate oxalate (ox) ligand. The N atoms of the HydEt-en ligand and the O atoms of ox ligand form the basal plane, while the O atom of the ethanol group of the HydEt-en ligand is located in the axial position. The complex mol­ecules participate in a supra­molecular assembly through N—H⋯O and O—H⋯O hydrogen bonds between HydEt-en and ox ligands

Local and global modes of drug action in biochemical networks

It becomes increasingly accepted that a shift is needed from the traditional target-based approach of drug development to an integrated perspective of drug action in biochemical systems. We here present an integrative analysis of the interactions between drugs and metabolism based on the concept of drug scope. The drug scope represents the set of metabolic compounds and reactions that are potentially affected by a drug. We constructed and analyzed the scopes of all US approved drugs having metabolic targets. Our analysis shows that the distribution of drug scopes is highly uneven, and that drugs can be classified into several categories based on their scopes. Some of them have small scopes corresponding to localized action, while others have large scopes corresponding to potential large-scale systemic action. These groups are well conserved throughout different topologies of the underlying metabolic network. They can furthermore be associated to specific drug therapeutic properties

State stigmatization in urban Turkey : Managing the 'insurgent' squatter dwellers in Dikmen Valley

This paper contributes to the accounts of territorial stigmatisation by examining the state role in it in the case of Turkey, a country that suffers from growing state power. The existing debates are mainly restricted to its function as an economic strategy paving the way for capital accumulation through devaluing working‐class people and places. Drawing on textual analysis of political speeches, local newsletters and mainstream national newspapers and fieldwork material that include interviews and observations in Dikmen Valley where some squatter communities mobilised against the state‐imposed urban transformation project, I demonstrate that state conceptualisation of “problem people” targets the “insurgent” rather than the “unprofitable” groups. Stigma in urban settings functions in inciting the desire to meet the patterns deemed appropriate by the state, rather than the market. Moving from that, I argue that stigma is used as a state‐led political strategy, which is integral to the growing authoritarianism in Turkey

Constraints on Non-Standard Neutrino Interactions and Unparticle Physics with Neutrino-Electron Scattering at the Kuo-Sheng Nuclear Power Reactor

Neutrino-electron scatterings are purely leptonic processes with robust Standard Model (SM) predictions. Their measurements can therefore provide constraints to physics beyond SM. The \nuebar-e data taken at the Kuo-Sheng Reactor Neutrino Laboratory were used to probe two scenarios: Non-Standard Neutrino Interactions (NSI) and Unparticle Physics. New constraints were placed to the NSI parameters (\el,\er) and (\etl,\etr) for the Non-Universal and Flavor-Changing channels, respectively, as well as to the coupling constants for scalar ($\lambda_0$) and vector ($\lambda_1$) unparticles to the neutrinos and electrons.Comment: 8 pages, 6 figures, 1 table ; Published Version in V2 with minor revision

The Mediterranean Island Wetlands (MedIsWet) inventory: strengths and shortfalls of the currently available floristic data

MedIsWet (Conservation of the island wetlands of the Mediterranean Basin) is a MAVA funded project which aims at investigating all seasonal or permanent island wetlands both natural and artificial, with a minimum extent of 0.1 hectares. More than 16,000 wetlands from almost all the Mediterranean, including islands from France, Italy, Malta, Croatia, Cyprus, Tunisia, Turkey, Greece and Spain were mapped. Over 2,500 of them were inventoried in the field and more than 500 scientific contributions catalogued. In total, more than 35,000 plant occurrences were uploaded, in a standardised and comparable way, on the national open-source web portals. These can be related to the recorded threats, uses and other spatially retrievable information. Here, we show strengths and shortfalls of the already available information about the floristic records. Although further improvements are needed, we discuss how these data can be used for research and policy actions and to develop conservation projects

Modularity in Protein Complex and Drug Interactions Reveals New Polypharmacological Properties

Recent studies have highlighted the importance of interconnectivity in a large range of molecular and human disease-related systems. Network medicine has emerged as a new paradigm to deal with complex diseases. Connections between protein complexes and key diseases have been suggested for decades. However, it was not until recently that protein complexes were identified and classified in sufficient amounts to carry out a large-scale analysis of the human protein complex system. We here present the first systematic and comprehensive set of relationships between protein complexes and associated drugs and analyzed their topological features. The network structure is characterized by a high modularity, both in the bipartite graph and in its projections, indicating that its topology is highly distinct from a random network and that it contains a rich and heterogeneous internal modular structure. To unravel the relationships between modules of protein complexes, drugs and diseases, we investigated in depth the origins of this modular structure in examples of particular diseases. This analysis unveils new associations between diseases and protein complexes and highlights the potential role of polypharmacological drugs, which target multiple cellular functions to combat complex diseases driven by gain-of-function mutations