Affine vector fields on Finsle manifolds

We give characterizations of affine transformations and affine vector fields in terms of the spray. By utilizing the Jacobi type equation that characterizes affine vector fields, we prove some rigidity theorems of affine vector fields on compact or forward complete non-compact Finsler manifolds with non-positive total Ricci curvature.Comment: 9 page

Four new species of the genus Eurytenes Foerster (Hymenoptera: Braconidae: Opiinae) from China

The species of Eurytenes Foerster in China are revised and four new species are described fromChina: E. basinervis sp. n., E. glabratus sp. n., E. setoputeus sp. n. and E. rugosulcus sp. n. This genus is recorded from China for the first time

UTAUT Model, Smart Exhibition Sorted by Relevance: Word Cloud Visualization Review

The aim of the paper is to introduce a visualization method with word cloud visualization to illustrate evolution of the smart exhibition, other relevant exhibition modes with virtual presentation and the articles in the application of UTAUT model in a set of documents. The relationship between UTAUT model and smart area, and the smart exhibition and some other smart areas is to be presented rapidly and evidently. This article provides interactive visual analysis of smart exhibition sorted by relevance and the industries or fields in the application of the UTAUT Model by a set of key words, at different time points based on the presentation of D2 or D3 to highlight the core word to make the trend of the smart exhibition clearly understood

Tie-dye technique and pattern features

Relationship between tie-dye technique and image pattern has been studied. Based on digital image processing, average value of HSV (hue, saturation, value) tri-component of valid tie-dye area, proportion of incompletely dyed area in HSV color space and the Tamura first three texture features of digital tie-dye image have been extracted. Then, the repeated tests and analysis of variance (ANOVA) of rotation speed and concentration have been done. The results show the obvious impact of concentration and rotation speed on the color and texture feature of tie-dye pattern. Furthermore, back propagation neutral network is developed and partial pattern features with low correlation is used to forecast the tie-dye concentration and rotation speed. The experiment results show the 100% rate of forecast, which proves that pattern features can effectively achieve the technique forecast

Global analysis of genomic instability caused by DNA replication stress in Saccharomyces cerevisiae

One important source of genomic instability associated with tumor cells is DNA replication stress. In the current study, replication stress was induced in yeast by a 10-fold reduction in the level of the replicative DNA polymerase δ. By DNA microarray analysis and high-throughput DNA sequencing, we showed that this stress resulted in very high rates of both large (aneuploidy, mitotic recombination, deletions and duplications, and translocations) and small (point mutations and small insertion/deletions) genetic alterations. Some of these changes resulted in a selective growth advantage of the cells, demonstrating the role of elevated genetic instability in the rapid evolution of cells in challenging growth conditions

The MLH1 2101C>A (Q701K) variant increases the risk of gastric cancer in Chinese males

<p>Abstract</p> <p>Background</p> <p>Gastric cancer is one of the most common cancers affecting East Asians, and <it>MLH1 </it>could play a critical role during tumorigenesis in this condition.</p> <p>Methods</p> <p>Samples from 236 Chinese patients suffering from gastric cancer were screened for <it>MLH1 </it>germline mutations. Carrier frequencies of the mutations were compared between gastric cancer patients and 240 cancer-free controls. Bioinformatic analysis was used to predict the effect of these mutations on protein function and mRNA splicing.</p> <p>Results</p> <p>Six <it>MLH1 </it>sequence alterations were identified in gastric cancer patients including two promoter region substitutions, -93G>A and -28A>G, and four missense mutations 649C>T (R217C), 655A>G (I219V), 1151T>A (V384D) and 2101C>A (Q701K). Compared with the <it>MLH1 </it>2101CC genotype, the 2101CA genotype was associated with a risk of gastric cancer (OR = 8.42, 95% CI = 1.04-68.06) in males. Furthermore, the <it>MLH1 </it>2101C>A mutant was predicted by <it>in silico </it>analysis to affect exon splicing ability. Immunohistochemistry of one index patient carrying the <it>MLH1 </it>2101C>A mutation demonstrated a loss of MLH1 protein and normal expression of MSH2 and E-cadherin. No significant differences were demonstrated between cases and controls for the other five <it>MLH1 </it>variants but the data indicated an ethnic difference in the frequency of these variations between Eastern Asians and Western populations.</p> <p>Conclusions</p> <p>An ethnic-specific <it>MLH1 </it>mutation spectrum occurred in Chinese gastric cancer patients. The <it>MLH1 </it>2101C>A mutation could be a marker for susceptibility to gastric cancer, particularly in males.</p