Description of a digital computer simulation of an Annular Momentum Control Device (AMCD) laboratory test model

A description of a digital computer simulation of an Annular Momentum Control Device (AMCD) laboratory model is presented. The AMCD is a momentum exchange device which is under development as an advanced control effector for spacecraft attitude control systems. The digital computer simulation of this device incorporates the following models: six degree of freedom rigid body dynamics; rim warp; controller dynamics; nonlinear distributed element axial bearings; as well as power driver and power supply current limits. An annotated FORTRAN IV source code listing of the computer program is included

Analysis and simulation of a magnetic bearing suspension system for a laboratory model annular momentum control device

A linear analysis and the results of a nonlinear simulation of a magnetic bearing suspension system which uses permanent magnet flux biasing are presented. The magnetic bearing suspension is part of a 4068 N-m-s (3000 lb-ft-sec) laboratory model annular momentum control device (AMCD). The simulation includes rigid body rim dynamics, linear and nonlinear axial actuators, linear radial actuators, axial and radial rim warp, and power supply and power driver current limits

Real-time digital-computer-hardware simulation of a spacecraft with control-moment-gyroscope stabilization

Computer simulation of Apollo Telescope Mount to evaluate performance of control moment gyroscope system used for stabilizatio

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma‑induced coagulopathy in adult trauma patients with bleeding

This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2015, Issue 2. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.Trauma-induced coagulopathy (TIC) is a disorder of the blood clotting process that occurs soon after trauma injury. A diagnosis of TIC on admission is associated with increased mortality rates, increased burdens of transfusion, greater risks of complications and longer stays in critical care. Current diagnostic testing follows local hospital processes and normally involves conventional coagulation tests including prothrombin time ratio/international normalized ratio (PTr/INR), activated partial prothrombin time and full blood count. In some centres, thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are standard tests, but in the UK they are more commonly used in research settings

EVALUATION OF PREHOSPITAL BLOOD PRODUCTS TO ATTENUATE ACUTE COAGULOPATHY OF TRAUMA IN A MODEL OF SEVERE INJURY AND SHOCK IN ANESTHETIZED PIGS

This material is licensed under the terms of the Open Government Licence except where otherwise statedUK Ministry of Defence

A near-infrared spectroscopic screening of the red giant populations in omega Centauri

Near-infrared spectra of 21 giants in omega Centauri, spanning the whole range of metallicities observed in this cluster, are presented. This work is part of a coordinated photometric and spectroscopic campaign in the optical and in the infrared, aimed at studying the complex stellar population of omega Centauri and understanding its formation and chemical evolution. By analyzing the several CO and OH molecular bands and atomic lines in the spectra of the selected giants, metal abundances and abundance ratios have been obtained. The existence of three major metallicity regimes at [Fe/H]=-1.6, -1.2 and [Fe/H]<-0.5 has been confirmed. The most metal-rich stars in our sample show a lower (if any) alpha-enhancement when compared to the more metal-poor components, suggesting that they should have formed in a medium significantly polluted by type Ia supernova ejecta. Isotopic carbon abundances have been also inferred, providing an average 13C/12C=4, which clearly indicates that extra-mixing processes occurred in the stellar interiors during the ascent on the Red Giant Branch.Comment: 22 pages, 7 .ps figures. aastex. Accepted for pubilcation in the Astrophysical Journa

Manageable creativity

This article notes a perception in mainstream management theory and practice that creativity has shifted from being disruptive or destructive to 'manageable'. This concept of manageable creativity in business is reflected in a similar rhetoric in cultural policy, especially towards the creative industries. The article argues that the idea of 'manageable creativity' can be traced back to a 'heroic' and a 'structural' model of creativity. It is argued that the 'heroic' model of creativity is being subsumed within a 'structural' model which emphasises the systems and infrastructure around individual creativity rather than focusing on raw talent and pure content. Yet this structured approach carries problems of its own, in particular a tendency to overlook the unpredictability of creative processes, people and products. Ironically, it may be that some confusion in our policies towards creativity is inevitable, reflecting the paradoxes and transitions which characterise the creative process

Developing Artemisia annua for the extraction of artemisinin to treat multi-drug resistant malaria

Keynote Lecture presented at the 23rd Conference on Isoprenoids. Minsk, Belarus, September 4-7, 2016Semi-synthetic derivatives of the sesquiterpene artemisinin have worldwide become the main treatment for P. falciparum malaria. Artemisinin-combination therapies (ACTs), containing artemether or artesunate combined with non-isoprenoid drugs, are recommended as first line treatment by the World Health Organization, particularly in areas where resistance against quinine and quinine analogues has developed. Whereas methods for the total synthesis of artemisinin have been developed, artemisinin extracted from the leaves of Artemisia annua L. (Asteraceae) is still the preferred source for commercial production of antimalarial drugs. The biosynthetic pathway of artemisinin is well-known and a number of genes that regulate artemisinin biosynthesis have been identified. Various attempts have been made to enhance the yield of artemisinin in crops or plant cell cultures through the use of genetic engineering. Another approach has been semi-synthesis of artemisinin via artemisinic acid in genetically engineered yeast. Although genetic engineering holds a great promise for the future, currently the largest improvements in artemisinin yield have been obtained through creation of high-yielding varieties by classical breeding programs combined with modern agricultural production techniques

The Brexit Botnet and User-Generated Hyperpartisan News

In this paper we uncover a network of Twitterbots comprising 13,493 accounts that tweeted the U.K. E.U. membership referendum, only to disappear from Twitter shortly after the ballot. We compare active users to this set of political bots with respect to temporal tweeting behavior, the size and speed of retweet cascades, and the composition of their retweet cascades (user-to-bot vs. bot-to-bot) to evidence strategies for bot deployment. Our results move forward the analysis of political bots by showing that Twitterbots can be effective at rapidly generating small to medium-sized cascades; that the retweeted content comprises user-generated hyperpartisan news, which is not strictly fake news, but whose shelf life is remarkably short; and, finally, that a botnet may be organized in specialized tiers or clusters dedicated to replicating either active users or content generated by other bots

The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder

Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the zinc-finger ZNF804A gene. These illnesses have also been associated with white matter abnormalities, reflected by reductions in fractional anisotropy (FA), measured using diffusion tensor imaging (DTI). We assessed the impact of the CACNA1C psychosis risk variant on FA in SZ, BD and health. 230 individuals (with existing ZNF804A rs1344706 genotype data) were genotyped for CACNA1C rs1006737 and underwent DTI. FA data was analysed with tract-based spatial statistics and threshold-free cluster enhancement significance correction (p < 0.05) to detect effects of CACNA1C genotype on FA, and its potential interaction with ZNF804A genotype and with diagnosis, on FA. There was no significant main effect of the CACNA1C genotype on FA, nor diagnosis by genotype(s) interactions. Nevertheless, when inspecting SZ in particular, risk allele carriers had significantly lower FA than the protective genotype individuals, in portions of the left middle occipital and parahippocampal gyri, right cerebelleum, left optic radiation and left inferior and superior temporal gyri. Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ. Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737