Systematic Renormalization in Hamiltonian Light-Front Field Theory: The Massive Generalization

Hamiltonian light-front field theory can be used to solve for hadron states in QCD. To this end, a method has been developed for systematic renormalization of Hamiltonian light-front field theories, with the hope of applying the method to QCD. It assumed massless particles, so its immediate application to QCD is limited to gluon states or states where quark masses can be neglected. This paper builds on the previous work by including particle masses non-perturbatively, which is necessary for a full treatment of QCD. We show that several subtle new issues are encountered when including masses non-perturbatively. The method with masses is algebraically and conceptually more difficult; however, we focus on how the methods differ. We demonstrate the method using massive phi^3 theory in 5+1 dimensions, which has important similarities to QCD.Comment: 7 pages, 2 figures. Corrected error in Eq. (11), v3: Added extra disclaimer after Eq. (2), and some clarification at end of Sec. 3.3. Final published versio

The Modification of Spousal Interaction After Aphasia

Researchers have investigated the ways spouses collaboratively overcome the communication barriers they face subsequent to aphasia in one of the partners (e.g., Oelschlaeger & Damico, 2003). These studies have demonstrated ways that the interactional dynamic is employed to re-establish social action after aphasia. However, little has been done to determine how spousal dyads created these modifications. This study was undertaken to investigate how the evolution of the described adaptations to conversation within spousal dyads was accomplished

The Origins of [CII] Emission in Local Star-forming Galaxies

The [CII] 158um fine-structure line is the brightest emission line observed in local star-forming galaxies. As a major coolant of the gas-phase interstellar medium, [CII] balances the heating, including that due to far-ultraviolet photons, which heat the gas via the photoelectric effect. However, the origin of [CII] emission remains unclear, because C+ can be found in multiple phases of the interstellar medium. Here we measure the fractions of [CII] emission originating in the ionized and neutral gas phases of a sample of nearby galaxies. We use the [NII] 205um fine-structure line to trace the ionized medium, thereby eliminating the strong density dependence that exists in the ratio of [CII]/[NII] 122um. Using the FIR [CII] and [NII] emission detected by the KINGFISH and Beyond the Peak Herschel programs, we show that 60-80% of [CII] emission originates from neutral gas. We find that the fraction of [CII] originating in the neutral medium has a weak dependence on dust temperature and the surface density of star formation, and a stronger dependence on the gas-phase metallicity. In metal-rich environments, the relatively cooler ionized gas makes substantially larger contributions to total [CII] emission than at low abundance, contrary to prior expectations. Approximate calibrations of this metallicity trend are provided.Comment: 8 pages, accepted for publication in Ap

Glueballs in a Hamiltonian Light-Front Approach to Pure-Glue QCD

We calculate a renormalized Hamiltonian for pure-glue QCD and diagonalize it. The renormalization procedure is designed to produce a Hamiltonian that will yield physical states that rapidly converge in an expansion in free-particle Fock-space sectors. To make this possible, we use light-front field theory to isolate vacuum effects, and we place a smooth cutoff on the Hamiltonian to force its free-state matrix elements to quickly decrease as the difference of the free masses of the states increases. The cutoff violates a number of physical principles of light-front pure-glue QCD, including Lorentz covariance and gauge covariance. This means that the operators in the Hamiltonian are not required to respect these physical principles. However, by requiring the Hamiltonian to produce cutoff-independent physical quantities and by requiring it to respect the unviolated physical principles of pure-glue QCD, we are able to derive recursion relations that define the Hamiltonian to all orders in perturbation theory in terms of the running coupling. We approximate all physical states as two-gluon states, and use our recursion relations to calculate to second order the part of the Hamiltonian that is required to compute the spectrum. We diagonalize the Hamiltonian using basis-function expansions for the gluons' color, spin, and momentum degrees of freedom. We examine the sensitivity of our results to the cutoff and use them to analyze the nonperturbative scale dependence of the coupling. We investigate the effect of the dynamical rotational symmetry of light-front field theory on the rotational degeneracies of the spectrum and compare the spectrum to recent lattice results. Finally, we examine our wave functions and analyze the various sources of error in our calculation.Comment: 75 pages, 17 figures, 1 tabl

The Impact of Spontaneous Recovery in Clinical Aphasiology

In clinical aphasiology, there are a number of well-accepted concepts that are considered organizing constructs in the discipline. One such construct is the concept of spontaneous recovery (SR). This construct influences the expectations that we hold regarding the time frame for greatest recovery and for best clinical response, and a host of theoretical and organizing principles that determine much of our planning and research design and that guide our expectations with respect to treatment, recovery, reimbursement, and explanatory mechanisms for recovery. However, the construct itself has been little studied

Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low - and high- grade glioma surgery

Biomarkers are indicators of biological processes and hold promise for the diagnosis and treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked intra- and inter-tumor variability. The extent of surgical resection is a significant factor influencing post-surgical recurrence and prognosis. Here, we used fluorescence and reflectance spectral signatures for in vivo quantification of multiple biomarkers during glioma surgery, with fluorescence contrast provided by exogenously-induced protoporphyrin IX (PpIX) following administration of 5-aminolevulinic acid. We performed light-transport modeling to quantify multiple biomarkers indicative of tumor biological processes, including the local concentration of PpIX and associated photoproducts, total hemoglobin concentration, oxygen saturation, and optical scattering parameters.We developed a diagnostic algorithm for intra-operative tissue delineation that accounts for the combined tumor-specific predictive capabilities of these quantitative biomarkers. Tumor tissue delineation achieved accuracies of up to 94% (specificity=94%, sensitivity=94%) across a range of glioma histologies beyond current state-of-the-art optical approaches, including state-of-the-art fluorescence image guidance. This multiple biomarker strategy opens the door to optical methods for surgical guidance that use quantification of well-established neoplastic processes. Future work would seek to validate the predictive power of this proof-of-concept study in a separate larger cohort of patients

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information regarding the effect of berberine on colon tumor growth is limited. Here, we investigated the mechanisms underlying the effects of berberine on regulating the fate of colon tumor cells, specifically the mouse immorto-Min colonic epithelial (IMCE) cells carrying the Apcmin mutation, and of normal colon epithelial cells, namely young adult mouse colonic epithelium (YAMC) cells. Berberine decreased colon tumor colony formation in agar, and induced cell death and LDH release in a time- and concentration-dependent manner in IMCE cells. In contrast, YAMC cells were not sensitive to berberine-induced cell death. Berberine did not stimulate caspase activation, and PARP cleavage and berberine-induced cell death were not affected by a caspase inhibitor in IMCE cells. Rather, berberine stimulated a caspase-independent cell death mediator, apoptosis-inducing factor (AIF) release from mitochondria and nuclear translocation in a ROS production-dependent manner. Amelioration of berberine-stimulated ROS production or suppression of AIF expression blocked berberine-induced cell death and LDH release in IMCE cells. Furthermore, two targets of ROS production in cells, cathepsin B release from lysosomes and PARP activation were induced by berberine. Blockage of either of these pathways decreased berberine-induced AIF activation and cell death in IMCE cells. Thus, berberine-stimulated ROS production leads to cathepsin B release and PARP activation-dependent AIF activation, resulting in caspase-independent cell death in colon tumor cells. Notably, normal colon epithelial cells are less susceptible to berberine-induced cell death, which suggests the specific inhibitory effects of berberine on colon tumor cell growth

Anastral spindle assembly and γ-tubulin in Drosophila oocytes

<p>Abstract</p> <p>Background</p> <p>Anastral spindles assemble by a mechanism that involves microtubule nucleation and growth from chromatin. It is still uncertain whether γ-tubulin, a microtubule nucleator essential for mitotic spindle assembly and maintenance, plays a role. Not only is the requirement for γ-tubulin to form anastral <it>Drosophila </it>oocyte meiosis I spindles controversial, but its presence in oocyte meiosis I spindles has not been demonstrated and is uncertain.</p> <p>Results</p> <p>We show, for the first time, using a bright GFP fusion protein and live imaging, that the <it>Drosophila </it>maternally-expressed γTub37C is present at low levels in oocyte meiosis I spindles. Despite this, we find that formation of bipolar meiosis I spindles does not require functional γTub37C, extending previous findings by others. Fluorescence photobleaching assays show rapid recovery of γTub37C in the meiosis I spindle, similar to the cytoplasm, indicating weak binding by γTub37C to spindles, and fits of a new, potentially more accurate model for fluorescence recovery yield kinetic parameters consistent with transient, diffusional binding.</p> <p>Conclusions</p> <p>The FRAP results, together with its mutant effects late in meiosis I, indicate that γTub37C may perform a role subsequent to metaphase I, rather than nucleating microtubules for meiosis I spindle formation. Weak binding to the meiosis I spindle could stabilize pre-existing microtubules or position γ-tubulin for function during meiosis II spindle assembly, which follows rapidly upon oocyte activation and completion of the meiosis I division.</p

Magnetic coupling in a hybrid Mn(ii) acetylene dicarboxylate

The design of ligands that mediate through-bond long range super-exchange in metal–organic hybrid materials would expand chemical space beyond the commonly observed short range, low temperature magnetic ordering. Here we examine acetylene dicarboxylate as a potential ligand that could install long range magnetic ordering due to its spatially continuous frontier orbitals. Using a known Mn(II)-containing coordination polymer we compute and measure the electronic structure and magnetic ordering. In this case, the latter is weak owing to the sub-optimal ligand coordination geometry, with a critical temperature of 2.5 K