Mapping the engineering education research landscape in Ireland and the UK

The growth of Engineering Education Research (EER) has led to claims about it becoming a globally connected field of inquiry. This paper presents data on the development of EER within the UK and Ireland with the aim of contributing towards our understanding of the field. A computer-aided process was used to extract the names of authors, affiliated with UK and Irish institutions, that had published in a sample of 13 different EER journals in the years 2018 and 2019. We identified 122 UK authors and 17 from the Republic of Ireland. Selected experts in both countries were contacted to obtain complementary data that were used to build a picture of the research landscape in which EER practitioners function. Similarities and differences between EER in both geographic contexts were identified. In both there were few institutions listed as having EER centres, and it was more common for participants to refer to individual researchers. There also appeared to be a lack of formal PhD programmes and funding opportunities in EER within both countries. Whilst recognition for EER in the UK was primarily associated with teaching awards and fellowships, in Ireland EER outputs appeared to be as valued as disciplinary research activities. The overall portrait that emerges from the data collected suggests that in both the UK and Ireland, EER does not benefit from a national support infrastructure but rather, is typically carried out by individuals or small groups of researchers

Mental Health Screening: Pennsylvania\u27s Experience In Juvenile Detention

Describes the Juvenile Detention Centers Association of Pennsylvania\u27s project to examine the mental health needs of detained youths

Eğri bacağın intikamı

Valentine Williams'ın Son Saat'te yayımlanan Eğri Bacağın İntikamı adlı romanının ilk ve son tefrikalar

Inequality and polarisation in health systems’ responsiveness: a cross-country analysis

The World Health Report 2000 proposed three fundamental goals for health systems encompassing population health, health care finance and health systems responsiveness. The goals incorporate both an efficiency and equity dimension. While inequalities in population health and health care finance have motivated two important strands of research, inequalities in responsiveness have received less attention in health economics. This paper examines inequality and polarisation in responsiveness, bridging this gap in the literature and contributing towards an integrated analysis of health systems performance. It uses data from the World Health Survey to measure and compare inequalities in responsiveness across 25 European countries. In order to respect the inherently ordinal nature of the responsiveness data, median-based measures of inequality and polarisation are employed. The results suggest that, in the face of wide differences in the health systems analysed, there exists large variability in inequality in responsiveness across countries

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas.

Anaplastic (ATC) and certain follicular thyroid-carcinomas (FTCs) are radioresistant. The Phosphatidylinositide 3-kinase (PI3K) pathway is commonly hyperactivated in thyroid-carcinomas. PI3K can modify the PI3K-related kinases (PIKKs) in response to radiation: How PIKKs interact with PI3K and contribute to radioresistance in thyroid-carcinomas is unknown. Further uncertainties exist in how these interactions function under the radioresistant hypoxic microenvironment. Under normoxia/anoxia, ATC (8505c) and FTC (FTC-133) cells were irradiated, with PI3K-inhibition (via GDC-0941 and PTEN-reconstitution into PTEN-null FTC-133s) and effects on PIKK-activation, DNA-damage, clonogenic-survival and cell cycle, assessed. FTC-xenografts were treated with 5 × 2 Gy, ± 50 mg/kg GDC-0941 (twice-daily; orally) for 14 days and PIKK-activation and tumour-growth assessed. PIKK-expression was additionally assessed in 12 human papillary thyroid-carcinomas, 13 FTCs and 12 ATCs. GDC-0941 inhibited radiation-induced activation of Ataxia-telangiectasia mutated (ATM), ATM-and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Inhibition of ATM and DNA-PKcs was PI3K-dependent, since activation was reduced in PTEN-reconstituted FTC-133s. Inhibition of PIKK-activation was greater under anoxia: Consequently, whilst DNA-damage was increased and prolonged under both normoxia and anoxia, PI3K-inhibition only reduced clonogenic-survival under anoxia. GDC-0941 abrogated radiation-induced cell cycle arrest, an effect most likely linked to the marked inhibition of ATR-activation. Importantly, GDC-0941 inhibited radiation-induced PIKK-activation in FTC-xenografts leading to a significant increase in time taken for tumours to triple in size: 26.5 ± 5 days (radiation-alone) versus 31.5 ± 5 days (dual-treatment). PIKKs were highly expressed across human thyroid-carcinoma classifications, with ATM scoring consistently lower. Interestingly, some loss of ATM and DNA-PKcs was observed. These data provide new insight into the mechanisms of hypoxia-associated radioresistance in thyroid-carcinoma

2010 YCAP Needs Assessment Report

This report outlines the Yamhill Community Action Partnership (YCAP) areas of need, strength, and improvement. Low income and unemployed individuals receive significant support through YCAP programs, including transportation, housing, and bill pay assistance. YCAP programs were assessed during the spring of 2010 through a client survey