A Ética como Competência Profissional na Formação: o pedagogo em foco

Este artigo visa compreender a ética como competência profissional transversal e autônoma no campo da formação do pedagogo. Discute as temáticas da competência e competência profissional; da ética, ética profissional como competência no cerne da formação do pedagogo. É pesquisa de cunho qualitativo, assente na revisão de literatura de renomados pensadores na esfera das competências profissionais. Dialoga especialmente com Boterf (2003), Caetano (2010), Estrela e Silva (2010), Garcia (1999) e Perrenoud (2000). Inaugura a discussão da ética enquanto dimensão práxis transversal e competência máxima no corpo da formação profissional

Modeling and measurement of the vibrational response of the ovine head as it relates to intracranial pressure

A combined experimental and analytical approach was taken to understand the vibrational characteristics of the ovine head, as a framework to use vibrational measurements to monitor changes in intracranial pressure. Modal analysis was performed on excised ovine heads to establish the spatial and spectral behavior of the head as a function of the presence of the soft extracranial and intracranial tissues and boundary conditions. Measurements of ovine cranial bone thickness, density, moisture content, and modulus of elasticity provided material property values for incorporation into analytical models of the ovine skull. Simplified spherical models were used in a parametric analysis to determine the sensitivity of the skull to changes in material properties and geometry. A detailed finite element model of the ovine skull was obtained by digitizing the cranial cavity of an ovine skull in 3D. Isotropic, homogeneous material properties which were measured for ovine cranial bone were incorporated into the detailed geometric model. The calculated modal shapes from the finite element model were validated by high correlations to experimental modal shapes as calculated by the Modal Assurance Criterion. While the finite element model described the vibrational behavior of the head adequately, it was relatively insensitive to increases in internal pressure of 50 cm H2O

Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial.

PurposeTo determine whether SD-101, a Toll-like receptor 9 agonist, potentiates the antitumor activity of anti-PD-1 antibodies in patients with anti-PD-1/PD-L1 naïve, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).Patients and methodsPatients with PD-1 Ab-naïve HNSCC received either 2 mg SD-101 injected in one to four lesions or 8 mg SD-101 injected into a single lesion weekly × 4 doses then every 3 weeks × 7 doses. Pembrolizumab was administered at 200 mg every 3 weeks.ResultsA total of 28 patients received 2 mg and 23 received 8 mg per injection, respectively. A total of 76% of patients had received prior systemic therapy. Combined positive score was ≥1 to < 20 in 35 patients (70%) and ≥ 20 in 15 patients (30%) of 50 patients with available data. There were 12 patients with grade ≥3 treatment-related adverse events (24%), and no treatment-related deaths. The objective response rate was 24% including 2 complete and 10 partial responses. The median duration of response was 7.0 [95% confidence interval (CI): 2.1-11.1] months. The response rate was higher in human papillomavirus-positive (HPV+) patients (44%, N = 16). Responses were not associated with PD-L1 expression levels or IFNγ-related gene expression at baseline. Responses were observed both in injected (32%) and in noninjected lesions (29%). Progression-free and overall survival at 9 months were 19.0% (95% CI: 9.1-31.7) and 64.7% (95% CI: 45.3-78.7), respectively.ConclusionsSD-101 combined with pembrolizumab induced objective responses, especially in HPV+ tumors, which were frequently associated with increased intratumoral inflammation and effector immune cell activity