Influential Article Review - Journal Progression and Organizational Model

This paper examines journal research. We present insights from a highly influential paper. Here are the highlights from this paper: This commentary reflects on how the themes in the Journal of Organization Design have evolved along with the field of organization design itself. Using topic modeling of abstracts, I assess the key topics or themes in the Journal of Organization Design and compare them to themes underlying design studies in mainstream management journals. I propose some mechanisms behind the differences and similarities and offer some implications for the future of the journal. For our overseas readers, we then present the insights from this paper in Spanish, French, Portuguese, and German

The effects of vendor and quality control variability in the procurement of raw materials in a bio-pharmaceutical company

Thesis (M. Eng. in Logistics)--Massachusetts Institute of Technology, Engineering Systems Division, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 65-66).Pharmaceutical companies have traditionally placed little emphasis on supply chain efficiencies and operations costs. With the changing landscape of expiring intellectual property rights and increased market segmentation, the need for improved supplier relations and inventory management is becoming paramount. This thesis presents a study of a procurement system within a biopharmaceutical company. The many sources of variation in delivery lead times from both suppliers and internal departments coupled with variation in manufacturing demand, has resulted in excess raw-material inventory at the company. By using discrete-events-simulation software to model the system and its inputs, we generate insights that can help the materials management team maximize their efforts to improve the system performance. In this particular case, it was found that reducing supplier lead time variability was far more effective in reducing the need for inventory than reducing average lead times or even internal lead times from the Quality Control department. The pharmaceutical company involved in this study would be best served by focusing its efforts on working with suppliers to increase the consistency of delivery for their raw materials. This increased consistency will allow them to reduce total inventory costs by reducing the variability of the raw-material supplies.by Jake T. Wheeler.M.Eng.in Logistic

Central Falls Welcome Sign Project Phase 2

For this design, the intent was to create a completely different identity for the City of Central Falls, as well as create a stronger connection with the state of Rhode Island. The curved shape that is created by the top portion of the design suggests a relationship with the Ocean State and the symbol of the wave that is seen throughout the State and even its license plate. It also creates a more modern approach with its abstract shape as well as creates a new and recognizable destination for tourists and locals. The use of brick for the base suggests that although new and different and for the future, it still holds true to the principles that make Central Falls the City it is today

Urban Design of Bristol Waterfront, Lower Thames Street

The marketplace is going to be one of the highlights on Thames Street, serving as a destination for leisure, shopping and dining. The concept of the project is to have indoor space continue out to the water, providing an outdoor space for dining and leisure, but also giving the boardwalk a resting point. The building is planned as two floors, with the fish market and multipurpose area on the first and an eatery, sitting area, balcony and facilities on the second. The building will be made of a light metal frame with panels to enclose the space and is designed with a folded glass panel that can be opened up to the outside, yet decrease wind pressure in a storm

Adams Memorial Library Children\u27s Room

The library spaces that were deemed most successful by the education students were those completed by the Robin Hood Foundation, which frequently rehabilitates underutilized spaces in inner-city schools to insert interactive, colorful and children-friendly library and learning spaces. Some shared suggestions to ensure such children- friendly accessibility were low bookshelves with book covers facing outwards, engaging and lively color schemes and comfortable furnishings

Radial spoke protein 9 is necessary for axoneme assembly in <i>Plasmodium</i> but not in trypanosomatid parasites

Flagella are important for eukaryote cell motility, including in sperm, and are vital for life cycle progression of many unicellular eukaryotic pathogens. The ‘9+2’ axoneme in most motile flagella comprises nine outer doublet and two central-pair singlet microtubules. T-shaped radial spokes protrude from the outer doublets towards the central pair and are necessary for effective beating. We asked whether there were radial spoke adaptations associated with parasite lineage-specific properties in apicomplexans and trypanosomatids. Following an orthologue search for experimentally uncharacterised radial spoke proteins (RSPs), we identified and analysed RSP9. Trypanosoma brucei and Leishmania mexicana have an extensive RSP complement, including two divergent RSP9 orthologues, necessary for flagellar beating and swimming. Detailed structural analysis showed that neither orthologue is needed for axoneme assembly in Leishmania. In contrast, Plasmodium has a reduced set of RSPs including a single RSP9 orthologue, deletion of which in Plasmodium berghei leads to failure of axoneme formation, failed male gamete release, greatly reduced fertilisation and inefficient life cycle progression in the mosquito. This indicates contrasting selection pressures on axoneme complexity, likely linked to the different mode of assembly of trypanosomatid versus Plasmodium flagella

First-year Sloan Digital Sky Survey-II (SDSS-II) Supernova Results: Hubble Diagram and Cosmological Parameters

We present measurements of the Hubble diagram for 103 Type Ia supernovae (SNe) with redshifts 0.04 < z < 0.42, discovered during the first season (Fall 2005) of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey. These data fill in the redshift "desert" between low- and high-redshift SN Ia surveys. We combine the SDSS-II measurements with new distance estimates for published SN data from the ESSENCE survey, the Supernova Legacy Survey, the Hubble Space Telescope, and a compilation of nearby SN Ia measurements. Combining the SN Hubble diagram with measurements of Baryon Acoustic Oscillations from the SDSS Luminous Red Galaxy sample and with CMB temperature anisotropy measurements from WMAP, we estimate the cosmological parameters w and Omega_M, assuming a spatially flat cosmological model (FwCDM) with constant dark energy equation of state parameter, w. For the FwCDM model and the combined sample of 288 SNe Ia, we find w = -0.76 +- 0.07(stat) +- 0.11(syst), Omega_M = 0.306 +- 0.019(stat) +- 0.023(syst) using MLCS2k2 and w = -0.96 +- 0.06(stat) +- 0.12(syst), Omega_M = 0.265 +- 0.016(stat) +- 0.025(syst) using the SALT-II fitter. We trace the discrepancy between these results to a difference in the rest-frame UV model combined with a different luminosity correction from color variations; these differences mostly affect the distance estimates for the SNLS and HST supernovae. We present detailed discussions of systematic errors for both light-curve methods and find that they both show data-model discrepancies in rest-frame $U$-band. For the SALT-II approach, we also see strong evidence for redshift-dependence of the color-luminosity parameter (beta). Restricting the analysis to the 136 SNe Ia in the Nearby+SDSS-II samples, we find much better agreement between the two analysis methods but with larger uncertainties.Comment: Accepted for publication by ApJ

Priorities for synthesis research in ecology and environmental science

ACKNOWLEDGMENTS We thank the National Science Foundation grant #1940692 for financial support for this workshop, and the National Center for Ecological Analysis and Synthesis (NCEAS) and its staff for logistical support.Peer reviewedPublisher PD

Priorities for synthesis research in ecology and environmental science

ACKNOWLEDGMENTS We thank the National Science Foundation grant #1940692 for financial support for this workshop, and the National Center for Ecological Analysis and Synthesis (NCEAS) and its staff for logistical support.Peer reviewedPublisher PD

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies