Thrombosis: A major contributor to global disease burden

AbstractThrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden due to VTE in low, middle and high income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging from 0.75 to 2.69 per 1,000 individuals in the population. The incidence increased to between 2 and 7 per 1,000 among those 70years of age or more. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low because of population aging. VTE associated with hospitalization was the leading cause of disability-adjusted-life-years (DALYs) lost in low and middle income countries, and second in high income countries, responsible for more DALYs lost than nosocomial pneumonia, catheter-related blood stream infections, and adverse drug events. VTE causes a major burden of disease across low, middle, and high income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems, and to evaluate if improved utilization of preventive measures will reduce the burden

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of therapy are being assessed in ongoing randomized controlled trials (RCTs) that focus on outpatients, hospitalized patients in medical wards, and patients critically ill with COVID-19. This paper provides a perspective of the ongoing or completed RCTs related to antithrombotic strategies used in COVID-19, the opportunities and challenges for the clinical trial enterprise, and areas of existing knowledge, as well as data gaps that may motivate the design of future RCTs. © 2021 American College of Cardiology Foundatio

Introduction of tactile simulator virteasy dental to teach the students of dental faculty at Russian peoples friendship university

Modern rules applicable to educational process, require the introduction of innovative technologies into learning process from higher education institutions. During the last few years the teaching in the countries of Europe and America takes place with the introduction of new technologies for e-learning, the introduction of virtual technologies in educational process. The appearance of clinical situation virtual modeling simulators allowed to introduce the modern opportunities for student learning into the educational process. © 2016, International Journal of Pharmacy and Technology. All rights reserved

Introduction of tactile simulator virteasy dental to teach the students of dental faculty at Russian peoples friendship university

Modern rules applicable to educational process, require the introduction of innovative technologies into learning process from higher education institutions. During the last few years the teaching in the countries of Europe and America takes place with the introduction of new technologies for e-learning, the introduction of virtual technologies in educational process. The appearance of clinical situation virtual modeling simulators allowed to introduce the modern opportunities for student learning into the educational process. © 2016, International Journal of Pharmacy and Technology. All rights reserved