Automatic detection and prediction of discontinuities in laser beam butt welding utilizing deep learning

Laser beam butt welding of thin sheets of high-alloy steel can be really challenging due to the formation of joint gaps, affecting weld seam quality. Industrial approaches rely on massive clamping systems to limit joint gap formation. However, those systems have to be adapted for each individually component geometry, making them very cost-intensive and leading to a limited flexibility. In contrast, jigless welding can be a high flexible alternative to substitute conventionally used clamping systems. Based on the collaboration of different actuators, motions systems or robots, the approach allows an almost free workpiece positioning. As a result, jigless welding gives the possibility for influencing the formation of the joint gap by realizing an active position control. However, the realization of an active position control requires an early and reliable error prediction to counteract the formation of joint gaps during laser beam welding. This paper proposes different approaches to predict the formation of joint gaps and gap induced weld discontinuities in terms of lack of fusion based on optical and tactile sensor data. Our approach achieves 97.4 % accuracy for video-based weld discontinuity detection and a mean absolute error of 0.02 mm to predict the formation of joint gaps based on tactile length measurements by using inductive probes

Production batch sizing and inventory level control using simulation software

Computer simulation has great application potential in the area of Production Engineering as a tool to support decision making as it allows to simulate the functioning of a real system through logical relationships, in order to observe its behavior under different scenarios. Which could not be practiced in the real system. In line with this aspect, the present work aims to present a report on the application of simulation for the design of production batches and inventory control, highlighting the process necessary for the construction of the generated simulation model, as well as the challenges and opportunities observed. In order to achieve the proposed objective, a literature review was carried out on the topics of interest; the choice and understanding of simulation software and; the survey of data from a large auto parts manufacturer located in the interior of the state of São Paulo. The main results were an increase in production volume from the inclusion and dimensioning of a buffer after the assembly process and a balance between the number of items of each component of the product structure in the supply with the real capacity of manufacturing cell processing. Cabe ressaltar que o modelo de simulação produto da pesquisa deste artigo pode ser aplicado como um sistema de apoio à decisão do gestor para a elaboração do planejamento estratégico e do planejamento operacional com o propósito de melhorar a capacidade de análise e decisão. It is important mentioning that the simulation model in this article can be applied as a support system decision for the preparation of strategic planning and operational planning, with the purpose of improving the analysis capacity for decision-making

Feelings of loneliness, COVID-19-specific-health anxiety and depressive symptoms during the first COVID-19 wave in Swiss persons with multiple sclerosis.

The aim of our study was to investigate whether self-reported feeling of loneliness (FoL) and COVID-19-specific health anxiety were associated with the presence of depressive symptoms during the first coronavirus disease 2019 (COVID-19) wave. Questionnaires of 603 persons of the Swiss Multiple Sclerosis Registry (SMSR) were cross-sectionally analyzed using descriptive and multivariable regression methods. The survey response rate was 63.9%. Depressive symptoms were assessed by the Beck Depression Inventory-Fast Screen (BDI-FS). COVID-19-specific health anxiety and FoL were measured using two 5-item Likert scaled pertinent questions. High scoring FoL (2.52, 95% confidence interval (CI) (2.06-2.98)) and/or COVID-19 specific health anxiety (1.36, 95% CI (0.87-1.85)) were significantly associated with depressive symptoms. Further stratification analysis showed that the impact of FoL on depressive symptoms affected all age groups. However, it was more pronounced in younger PwMS, whereas an impact of COVID-19 specific health anxiety on depressive symptoms was particularly observed in middle-aged PwMS. FoL and COVID-19-specific health anxiety were age-dependently associated with depressive symptoms during the first COVID-19 wave in Switzerland. Our findings could guide physicians, health authorities, and self-help groups to better accompany PwMS in times of public health crises

MCDA for sustainability assessment – insights to Helmholtz Association activities

The "MCDA for sustainability assessment – insights to Helmholtz Association activities" Working Paper aims to compile and reflect previous and on-going work within the Helmholtz Association related to MCDA, in particular, to present use cases and key methodological aspects. It has a focus on but is not limited to energy technologies and systems and is mainly based on the presentations held at the online workshop “Multi criteria decision analysis for sustainability assessment of energy technologies and systems”. The workshop was organized within the activities of the Helmholtz program ESD Topic 1 "Energy System Transformation" and took place on November 22nd, 2021

Whole brain radiation therapy alone versus radiosurgery for patients with 1–10 brain metastases from small cell lung cancer (ENCEPHALON Trial): study protocol for a randomized controlled trial

Background: Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosurgery (SRS). Methods/design: The present single-center prospective randomized study, conducted at Heidelberg University Hospital, compares neurocognitive function, as objectively measured by significant deterioration in Hopkins Verbal Learning Test – Revised total recall at 3 months. Fifty-six patients will be randomized to receive either SRS of all brain metastases (up to ten lesions) or WBRT. Secondary endpoints include intracranial progression (local tumor progression and number of new cerebral metastases), extracranial progression, overall survival, death due to brain metastases, local (neurological) progression-free survival, progression-free survival, changes in other cognitive performance measures, quality of life and toxicity. Discussion: Recent evidence suggests that SRS might be a promising treatment option for SCLC patients with brain metastases. The present trial is the first to prospectively investigate the treatment response, toxicity and neurocognition of WBRT and SRS in SCLC patients. Trial registration: Clinicaltrials.gov NCT03297788 . Registered September 29, 2017

Folding and Self-Assembly of the TatA Translocation Pore Based on a Charge Zipper Mechanism

SummaryWe propose a concept for the folding and self-assembly of the pore-forming TatA complex from the Twin-arginine translocase and of other membrane proteins based on electrostatic “charge zippers.” Each subunit of TatA consists of a transmembrane segment, an amphiphilic helix (APH), and a C-terminal densely charged region (DCR). The sequence of charges in the DCR is complementary to the charge pattern on the APH, suggesting that the protein can be “zipped up” by a ladder of seven salt bridges. The length of the resulting hairpin matches the lipid bilayer thickness, hence a transmembrane pore could self-assemble via intra- and intermolecular salt bridges. The steric feasibility was rationalized by molecular dynamics simulations, and experimental evidence was obtained by monitoring the monomer-oligomer equilibrium of specific charge mutants. Similar “charge zippers” are proposed for other membrane-associated proteins, e.g., the biofilm-inducing peptide TisB, the human antimicrobial peptide dermcidin, and the pestiviral ERNS protein

Lack of gene-language correlation due to reciprocal female but directional male admixture in Austronesians and non-Austronesians of East Timor

Nusa Tenggara, including East Timor, located at the crossroad between Island Southeast Asia, Near Oceania, and Australia, are characterized by a complex cultural structure harbouring speakers from two different major linguistic groups of different geographic origins (Austronesian (AN) and non-Austronesian (NAN)). This provides suitable possibilities to study gene-language relationship; however, previous studies from other parts of Nusa Tenggara reported conflicting evidence about gene-language correlation in this region. Aiming to investigate gene-language relationships including sex-mediated aspects in East Timor, we analysed the paternally inherited non-recombining part of the Y chromosome (NRY) and the maternally inherited mitochondrial (mt) DNA in a representative collection of AN-and NAN-speaking groups. Y-SNP (single-nucleotide polymorphism) data were newly generated for 273 samples and combined with previously established Y-STR (short tandem repeat) data of the same samples, and with previously established mtDNA data of 290 different samples with, however, very similar representation of geographic and linguistic coverage of the country. We found NRY and mtDNA haplogroups of previously described putative East/Southeast Asian (E/SEA) and Near Oceanian (NO) origins in both AN and NAN speakers of East Timor, albeit in different proportions, suggesting reciprocal genetic admixture between both linguistic groups for females, but directional admixture for males. Our data underline the dual genetic origin of East Timorese in E/SEA and NO, and highlight that substantial genetic admixtur

Hochwasserschutz an der Mulde - Vorbeugender Hochwasserschutz durch Wasserrückhalt in der Fläche unter besonderer Berücksichtigung naturschutzfachlicher Aspekte am Beispiel des Flusseinzugsgebietes der Mulde in Sachsen

Ziele für das vorliegende Projekt: - Entwicklung einer auf beliebige Einzugsgebiete übertragbaren Methodik, das Wasserrückhaltepotenzial flächendeckend zu ermitteln und Karten oder Pläne für die Ausweisung von potenziellen Hochwasserminderungsgebieten herzustellen, - Identifizierung von Synergieeffekten zwischen den Zielen und Maßnahmen des vorbeugenden Hochwasserschutzes und des Naturschutzes, - Entwicklung je eines Katalogs von multifunktionalen Hochwasserschutzmaßnahmen - dargestellt in sogenannten »Maßnahmen-Steckbriefen« - für die Bereiche Siedlungswasserwirtschaft und Landwirtschaft, - Softwarebezogene Verknüpfung eines vorhandenen Entscheidungshilfesystems mit den GIS-technisch aufbereiteten Daten des Muldeeinzugsgebietes und Aufstellen eines Regelwerks zur Definition geeigneter Maßnahmen, - Erstellung einer »Maßnahmenkarte« für den Bereich Siedlungswasserwirtschaft zur Beantwortung der Frage, welche Maßnahme an welchem Ort möglich und sinnvoll ist, - Erstellung von einzugsgebietsweiten »Fachplanerkarten« für den Bereich Landwirtschaft zur Beantwortung der Frage wo eine bestimmte Maßnahme möglich und sinnvoll ist, - Handlungsempfehlungen und beispielhafte Anwendungen naturschutzfachlicher Maßnahmen, - Beispielhafte Berechnung der Auswirkungen angenommener Umsetzungsszenarien im Bereich der Siedlungswasserwirtschaft und der Landwirtschaft auf den Hochwasserabfluss im Muldegebiet, - Erarbeitung einer Handlungsstrategie zur Umsetzung der vorgeschlagen Ziele und Maßnahmen (Umsetzungsinstrumente, Integration in die räumliche Planung), - Ökonomische Bewertung der vorgeschlagenen Ziele und Maßnahmen, unterteilt nach den Bereichen Siedlungswasserwirtschaft und Landwirtschaft, - Bewertung der derzeitigen Fördermöglichkeiten im Bereich der Landwirtschaft und Erarbeitung von Verbesserungsvorschlägen, - Zusammenfassende Bewertung flächenbezogener Maßnahmen zur Erhöhung des Wasserrückhalts bei Hochwasserereignissen und Ausblick auf weitergehende Untersuchungen

Helena’s Many Daughters: More Mitogenome Diversity behind the Most Common West Eurasian mtDNA Control Region Haplotype in an Extended Italian Population Sample

The high number of matching haplotypes of the most common mitochondrial (mt)DNA lineages are considered to be the greatest limitation for forensic applications. This study investigates the potential to solve this constraint by massively parallel sequencing a large number of mitogenomes that share the most common West Eurasian mtDNA control region (CR) haplotype motif (263G 315.1C 16519C). We augmented a pilot study on 29 to a total of 216 Italian mitogenomes that represents the largest set of the most common CR haplotype compiled from a single country. The extended population sample confirmed and extended the huge coding region diversity behind the most common CR motif. Complete mitogenome sequencing allowed for the detection of 163 distinct haplotypes, raising the power of discrimination from 0 (CR) to 99.6% (mitogenome). The mtDNAs were clustered into 61 named clades of haplogroup H and did not reveal phylogeographic trends within Italy. Rapid individualization approaches for investigative purposes are limited to the most frequent H clades of the dataset, viz. H1, H3, and H7