Specific wavelength colorimeter

A self contained, specific wavelength, single beam colorimeter is described for direct spectrophotometric measurement of the concentration of a given solute in a test sample. An electrical circuit employing a photoconductive cell converts the optical output into a linear, directly readable meter output. The colorimeter is simple to operate and is adapted for use in zero gravity conditions. In a specific application, the colorimeter is designed to analyze the concentration of iodine in potable water carried aboard a space vehicle such as the 4B stage of Skylab

Maser Source Finding Methods in HOPS

The {\bf H}$_2${\bf O} Southern Galactic {\bf P}lane {\bf S}urvey (HOPS) has observed 100 square degrees of the Galactic plane, using the Mopra radio telescope to search for emission from multiple spectral lines in the 12\,mm band (19.5\,--\,27.5\,GHz). Perhaps the most important of these spectral lines is the 22.2\,GHz water maser transition. We describe the methods used to identify water maser candidates and subsequent confirmation of the sources. Our methods involve a simple determination of likely candidates by searching peak emission maps, utilising the intrinsic nature of water maser emission - spatially unresolved and spectrally narrow-lined. We estimate completeness limits and compare our method with results from the {\sc Duchamp} source finder. We find that the two methods perform similarly. We conclude that the similarity in performance is due to the intrinsic limitation of the noise characteristics of the data. The advantages of our method are that it is slightly more efficient in eliminating spurious detections and is simple to implement. The disadvantage is that it is a manual method of finding sources and so is not practical on datasets much larger than HOPS, or for datasets with extended emission that needs to be characterised. We outline a two-stage method for the most efficient means of finding masers, using {\sc Duchamp}.Comment: 8 pages, 1 table, 4 figures. Accepted for publication in PASA special issue on Source Finding & Visualisatio

Adjunctive strategies in the management of resistant, 'undilatable' coronary lesions after successfully crossing a CTO with a guidewire.

Successful revascularisation of chronic total occlusions (CTOs) remains one of the greatest challenges in the era of contemporary percutaneous coronary intervention (PCI). Such lesions are encountered with increasing frequency in current clinical practice. A predictable increase in the future burden of CTO management can be anticipated given the ageing population, increased rates of renal failure, graft failure and diabetes mellitus. Given recent advances and developments in CTO PCI management, successful recanalisation can be anticipated in the majority of procedures undertaken at high-volume centres when performed by expert operators. Despite advances in device technology, the management of resistant, calcific lesions remains one of the greatest challenges in successful CTO intervention. Established techniques to modify calcific lesions include the use of high-pressure non-compliant balloon dilation, cutting-balloons, anchor balloons and high speed rotational atherectomy (HSRA). Novel approaches have proven to be safe and technically feasible where standard approaches have failed. A step-wise progression of strategies is demonstrated, from well-recognised techniques to techniques that should only be considered when standard manoeuvres have proven unsuccessful. These methods will be described in the setting of clinical examples and include use of very high-pressure non-compliant balloon dilation, intentional balloon rupture with vessel dissection or balloon assisted micro-dissection (BAM), excimer coronary laser atherectomy (ECLA) and use of HSRA in various 'offlabel' settings

New ammonia masers towards NGC6334I

We report the detection of new ammonia masers in the non-metastable (8,6) and (11,9) transitions towards the massive star forming region NGC6334I. Observations were made with the ATCA interferometer and the emitting region appears unresolved in the 2.7" x 0.8" beam, with deconvolved sizes less than an arcsecond. We estimate peak brightness temperatures of 7.8 x 10^5 and 1.2 x 10^5 K for the (8,6) and (11,9) transitions, respectively. The masers appear coincident both spatially and in velocity with a previously detected ammonia (6,6) maser. We also suggest that emission in the (10,9), (9,9) and (7,6) transitions may also be masers, based on their narrow line widths and overlapping velocity ranges with the above masers, as observed with the single-dish Mopra radiotelescope

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children.

© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate the preparation of better and safe medicines for children through linking research and information dissemination. It brings together the capabilities of the industry, academics, hospitals, and regulators within a common platform in order to scope the solid understanding of the major issues, which will underpin the progress towards the future of paediatric medicines we want.The EuPFI was formed in parallel to the adoption of regulations within the EU and USA and has served as a community that drives research and dissemination through publications and the organisation of annual conferences. The membership and reach of this group have grown since its inception in 2007 and continue to develop and evolve to meet the continuing needs and ambitions of research into and development of age appropriate medicines. Five diverse workstreams (age-appropriate medicines, Biopharmaceutics, Administration Devices, Excipients and Taste Assessment & Taste Masking (TATM)) direct specific workpackages on behalf of the EuPFI. Furthermore, EuPFI interacts with multiple diverse professional groups across the globe to ensure efficient working in the area of paediatric medicines. Strong commitment and active involvement of all EuPFI stakeholders have proved to be vital to effectively address knowledge gaps related to paediatric medicines, discuss potential areas for further research and identify issues that need more attention and analysis in the future.Peer reviewedFinal Accepted Versio

Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus.

The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV). Similar to NPCs derived from striatum of day 1 postnatal GFP-transgenic mice (GFP-NPCs), iPSC-derived NPCs (iPSC-NPCs) are able to differentiate into terminal neural cell types and express MHC class I and II in response to IFN-γ treatment. However, in contrast to postnatally-derived NPCs, iPSC-NPCs express low levels of carcinoembryonic antigen-cell adhesion molecule 1a (CEACAM1a), the surface receptor for JHMV, and are less susceptible to infection and virus-induced cytopathic effects. The relevance of this in terms of therapeutic application of NPCs resistant to viral infection is discussed

On The Complexity and Completeness of Static Constraints for Breaking Row and Column Symmetry

We consider a common type of symmetry where we have a matrix of decision variables with interchangeable rows and columns. A simple and efficient method to deal with such row and column symmetry is to post symmetry breaking constraints like DOUBLELEX and SNAKELEX. We provide a number of positive and negative results on posting such symmetry breaking constraints. On the positive side, we prove that we can compute in polynomial time a unique representative of an equivalence class in a matrix model with row and column symmetry if the number of rows (or of columns) is bounded and in a number of other special cases. On the negative side, we show that whilst DOUBLELEX and SNAKELEX are often effective in practice, they can leave a large number of symmetric solutions in the worst case. In addition, we prove that propagating DOUBLELEX completely is NP-hard. Finally we consider how to break row, column and value symmetry, correcting a result in the literature about the safeness of combining different symmetry breaking constraints. We end with the first experimental study on how much symmetry is left by DOUBLELEX and SNAKELEX on some benchmark problems.Comment: To appear in the Proceedings of the 16th International Conference on Principles and Practice of Constraint Programming (CP 2010

The nucleic acid revolution continues - will forensic biology become forensic molecular biology?

Molecular biology has evolved far beyond that which could have been predicted at the time DNA identity testing was established. Indeed we should now perhaps be referring to "forensic molecular biology." Aside from DNA's established role in identifying the "who" in crime investigations, other developments in medical and developmental molecular biology are now ripe for application to forensic challenges. The impact of DNA methylation and other post-fertilization DNA modifications, plus the emerging role of small RNAs in the control of gene expression, is re-writing our understanding of human biology. It is apparent that these emerging technologies will expand forensic molecular biology to allow for inferences about "when" a crime took place and "what" took place. However, just as the introduction of DNA identity testing engendered many challenges, so the expansion of molecular biology into these domains will raise again the issues of scientific validity, interpretation, probative value, and infringement of personal liberties. This Commentary ponders some of these emerging issues, and presents some ideas on how they will affect the conduct of forensic molecular biology in the foreseeable future

Factors influencing the utilisation of free-standing and alongside midwifery units in England: a qualitative research study

OBJECTIVE: To identify factors influencing the provision, utilisation and sustainability of midwifery units (MUs) in England. DESIGN: Case studies, using individual interviews and focus groups, in six National Health Service (NHS) Trust maternity services in England. SETTING AND PARTICIPANTS: NHS maternity services in different geographical areas of England Maternity care staff and service users from six NHS Trusts: two Trusts where more than 20% of all women gave birth in MUs, two Trusts where less than 10% of all women gave birth in MUs and two Trusts without MUs. Obstetric, midwifery and neonatal clinical leaders, managers, service user representatives and commissioners were individually interviewed (n=57). Twenty-six focus groups were undertaken with midwives (n=60) and service users (n=52). MAIN OUTCOME MEASURES: Factors influencing MU use. FINDINGS: The study findings identify several barriers to the uptake of MUs. Within a context of a history of obstetric-led provision and lack of decision-maker awareness of the clinical and economic evidence, most Trust managers and clinicians do not regard their MU provision as being as important as their obstetric unit (OU) provision. Therefore, it does not get embedded as an equal and parallel component in the Trust's overall maternity package of care. The analysis illuminates how implementation of complex interventions in health services is influenced by a range of factors including the medicalisation of childbirth, perceived financial constraints, adequate leadership and institutional norms protecting the status quo. CONCLUSIONS: There are significant obstacles to MUs reaching their full potential, especially free-standing midwifery units. These include the lack of commitment by providers to embed MUs as an essential service provision alongside their OUs, an absence of leadership to drive through these changes and the capacity and willingness of providers to address women's information needs. If these remain unaddressed, childbearing women's access to MUs will continue to be restricted

Supersonic combustion engine testbed, heat lightning

The design of a supersonic combustion engine testbed (SCET) aircraft is presented. The hypersonic waverider will utilize both supersonic combustion ramjet (SCRAMjet) and turbofan-ramjet engines. The waverider concept, system integration, electrical power, weight analysis, cockpit, landing skids, and configuration modeling are addressed in the configuration considerations. The subsonic, supersonic and hypersonic aerodynamics are presented along with the aerodynamic stability and landing analysis of the aircraft. The propulsion design considerations include: engine selection, turbofan ramjet inlets, SCRAMjet inlets and the SCRAMjet diffuser. The cooling requirements and system are covered along with the topics of materials and the hydrogen fuel tanks and insulation system. A cost analysis is presented and the appendices include: information about the subsonic wind tunnel test, shock expansion calculations, and an aerodynamic heat flux program