An exploration of absence and presence through the mediums of bronze, glass and resin figurative sculpture, within a narrative of memory

This research study was based upon three critical components. These include absence and presence, memory and the female nude. The problem statement aimed to determine how compositionally sound pairings and groupings of bronze, glass and resin figurative sculptures may be manipulated to create visual equilibrium in a work and communicate an inherent conceptual element. This necessitated the following research question which explored what the role of memory and the imago is within dualistic representations of the absent and present, as represented in the mediums of bronze, glass and resin. The creative and research processes culminate in the body of artwork, entitled Absence and Presence: in Search of Memory and the Imago, which is presented as a narrative installation and exhibition of sculptural work. This body of work was driven by the creation of a signifier and allegory for an absent presence or present absence which will always evoke the contemplation of this interplay between these two terms and the ways in which they define and become one another within the narrative of personal memory. Personal memories will always collide with the present and bring with them the memories of absence, but encourage the subject to make tangible this absence in order to confront it and in doing so, realise that it cannot be addressed separately from the presence which defines i

Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Unbalanced immune responses to pathogens can be life-threatening although the underlying regulatory mechanisms remain unknown. Here, we show a hypoxia-inducible factor 1α–dependent microRNA (miR)–210 up-regulation in monocytes and macrophages upon pathogen interaction. MiR-210 knockout in the hematopoietic lineage or in monocytes/macrophages mitigated the symptoms of endotoxemia, bacteremia, sepsis, and parasitosis, limiting the cytokine storm, organ damage/dysfunction, pathogen spreading, and lethality. Similarly, pharmacologic miR-210 inhibition improved the survival of septic mice. Mechanistically, miR-210 induction in activated macrophages supported a switch toward a proinflammatory state by lessening mitochondria respiration in favor of glycolysis, partly achieved by downmodulating the iron-sulfur cluster assembly enzyme ISCU. In humans, augmented miR-210 levels in circulating monocytes correlated with the incidence of sepsis, while serum levels of monocyte/macrophage-derived miR-210 were associated with sepsis mortality. Together, our data identify miR-210 as a fine-tuning regulator of macrophage metabolism and inflammatory responses, suggesting miR-210–based therapeutic and diagnostic strategies

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Dynamiques techniques et environnementales dans la vallée de la Falémé (Sénégal) : résultats de la 20ème campagne du programme « Peuplement humain et paléoenvironnement en Afrique

International audienc

Dynamiques techniques et environnementales dans la vallée de la Falémé (Sénégal) : résultats de la 20ème campagne du programme « Peuplement humain et paléoenvironnement en Afrique »

Cet article présente les résultats de la campagne de terrain menée au Sénégal oriental en 2017 dans le cadre du programme international « Peuplement humain et paléoenvironnement en Afrique ». Il intègre les résultats de deux projets complémentaires : le projet ANR-FNS CheRCHA, ainsi que le projet FNS Falémé. Le premier vise à reconstituer le cadre chronostratigraphique et les évolutions culturelles au Pléistocène et à l'Holocène ancien et moyen dans la vallée de la Falémé, tandis que le second est ciblé sur les dynamiques techniques des deux derniers millénaires au Sénégal oriental

A Felső-Tisza vidékének vízerőkészlet vizsgálata.

Szakdolgozatom kezdetén bemutatom közvetlen régiónk és hazánk vízenergia hasznosítását, majd áttérek a Felső-Tisza vidékén található nagy folyók - Tisza, Túr, Szamos, Kraszna - vízgyűjtő területeinek lehatárolására, amit kiegészítek vízhozam adatok elemzésével, majd egy kiválasztott műtárgyon javaslatot teszek egy megvalósuló vízenergia hasznosítás esetleges módosítására.szakirányú továbbképzésMegújuló energetikai szakemberg