Decaying warm dark matter and neutrino masses

Neutrino masses may arise from spontaneous breaking of ungauged lepton number. Due to quantum gravity effects the associated Goldstone boson - the majoron - will pick up a mass. We determine the lifetime and mass required by cosmic microwave background observations so that the massive majoron provides the observed dark matter of the Universe. The majoron DDM scenario fits nicely in models where neutrino masses arise a la seesaw, and may lead to other possible cosmological implications.Comment: 4 pages, 3 figures. Replaced to match published version. Minor changes made to address referees' comments. References adde

Impact of general reionization scenarios on extraction of inflationary parameters

Determination of whether the Harrison--Zel'dovich spectrum for primordial scalar perturbations is consistent with observations is sensitive to assumptions about the reionization scenario. In light of this result, we revisit constraints on inflationary models using more general reionization scenarios. While the bounds on the tensor-to-scalar ratio are largely unmodified, when different reionization schemes are addressed, hybrid models are back into the inflationary game. In the general reionization picture, we reconstruct both the shape and amplitude of the inflaton potential. We find a broader spectrum of potential shapes when relaxing the simple reionization restriction. An upper limit of $10^{16}$ GeV to the amplitude of the potential is found, regardless of the assumptions on the reionization history.Comment: 10 Pages, 9 figure

Cornering (quasi) degenerate neutrinos with cosmology

In light of the improved sensitivities of cosmological observations, we examine the status of quasi-degenerate neutrino mass scenarios. Within the simplest extension of the standard cosmological model with massive neutrinos, we find that quasi-degenerate neutrinos are severely constrained by present cosmological data and neutrino oscillation experiments. % % We find that Planck 2018 observations of cosmic microwave background (CMB) anisotropies disfavour quasi-degenerate neutrino masses at $2.4$ Gaussian $\sigma$'s, while adding Baryon acoustic oscillations (BAO) data brings the rejection to 5.9$\sigma$'s. % The highest statistical significance with which one would be able to rule out quasi-degeneracy would arise if the sum of neutrino masses is $\Sigma m_\nu = 60$ \meV (the minimum allowed by neutrino oscillation experiments); % indeed a sensitivity of 15 meV, as expected from a combination of future cosmological probes, would further improve the rejection level up to 17$\sigma$. % We discuss the robustness of these projections with respect to assumptions on the underlying cosmological model, and also compare them with bounds from $\beta$ decay endpoint and neutrinoless double beta decay studies.Comment: 19 pages, 6 figures, 1 tabl

Regenerative Strategy for Persistent Periprosthetic Leakage around Tracheoesophageal Puncture: Is It an Effective Long-Term Solution?

Autologous tissue-assisted regenerative procedures have been considered effective to close different types of fistula, including the leakage around tracheoesophageal puncture. The aim of this study was to retrospectively review 10 years of lipotransfer for persistent periprosthetic leakage in laryngectomized patients with voice prosthesis. Clinical records of patients who experienced periprosthetic leakage from December 2009 to December 2019 were reviewed. Patients receiving fat grafting were included. The leakage around the prosthesis was assessed with a methylene blue test. Twenty patients experiencing tracheoesophageal fistula enlargement were treated with fat grafting. At the one-month follow-up, all patients were considered improved with no leakage observed. At six months, a single injection was sufficient to solve 75% of cases (n 15), whereas 25% (n 5) required a second procedure. The overall success rate was 80% (n 16). Results remained stable for a follow-up of 5.54 � 3.97 years. Fat grafting performed around the voice prosthesis, thanks to its volumetric and regenerative properties, is a valid and lasting option to solve persistent periprosthetic leakage

Efficient bone formation by gene transfer of human LIM mineralization protein-3

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Sustainable Intensification in Crop-Livestock Systems

Extensive livestock production is the main animal source food system in the Pampas and Campos sub-regions in South America. Beef cattle and sheep convert forage biomass that humans cannot eat into nutrient-dense human-edible foods (meat and milk) and valuable co-products (wool). However, diverse global pressures are acting on Pampas systems including increasing demand for protein sources (food security), climate change, environmental footprint, and competition for land. The integration of small areas of pasture-crop rotations is an alternative for increasing efficiency and sustainable intensification of agroecosystems based on natural grasslands. Rotations led by improved pastures increase the carrying capacity and productivity of traditional Pampas systems, and include crop production (soybean, rice) as an opportunity for farm diversification and resilience. Therefore, mixed crop-livestock systems can feed more people in terms of calories and protein than what is possible with specialized systems. The higher carrying capacity in the area under the rotation may allow less intensive grazing management in larger areas of native grasslands reducing threats to biodiversity. Some of the integrated management practices in crop-livestock systems are perennial pastures to mitigate soil organic carbon losses during cropping, biological nitrogen fixation by legumes, grazing cover crops, crop residue grazing, dual-purpose crops, and harvesting grain and hay for livestock feed. Also, complementary crop and livestock production systems facilitate more efficient nutrient cycling and self-sufficient systems promoting the circular economy concept as a strategic approach toward system sustainability. Key to understanding the potential of mixed crop-livestock systems are productive, environmental, economic, and social factors that determine their performance, as well as trade-offs among them. Development, implementation, maintenance, and analysis of long-term crop-livestock platforms research provides science-based information to address complex biological systems, and to implement innovative public policies at national scale to regulate soil use and to prevent non-sustainable agricultural practices

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations, genome instability, heterochromatin loss, telomere dysfunction and premature entry into cellular senescence. Recently, we reported that telomere dysfunction induces the transcription of telomeric non-coding RNAs (tncRNAs) which control the DNA damage response (DDR) at dysfunctional telomeres. Here we show that progerin-induced telomere dysfunction induces the transcription of tncRNAs. Their functional inhibition by sequence-specific telomeric antisense oligonucleotides (tASOs) prevents full DDR activation and premature cellular senescence in various HGPS cell systems, including HGPS patient fibroblasts. We also show in vivo that tASO treatment significantly enhances skin homeostasis and lifespan in a transgenic HGPS mouse model. In summary, our results demonstrate an important role for telomeric DDR activation in HGPS progeroid detrimental phenotypes in vitro and in vivo