Ogus realization of 1-motives

After introducing the Ogus realization of 1-motives we prove that it is a fully faithful functor. More precisely, following a framework introduced by Ogus, considering an enriched structure on the de Rham realization of 1-motives over a number field, we show that it yields a full functor by making use of an algebraicity theorem of Bost

Nori 1-motives

Let EHM be Nori's category of effective homological mixed motives. In this paper, we consider the thick abelian subcategory EHM_1 generated by the i-th relative homology of pairs of varieties for i = 0,1. We show that EHM_1 is naturally equivalent to the abelian category M_1 of Deligne 1-motives with torsion; this is our main theorem. Along the way, we obtain several interesting results. Firstly, we realize M_1 as the universal abelian category obtained, using Nori's formalism, from the Betti representation of an explicit diagram of curves. Secondly, we obtain a conceptual proof of a theorem of Vologodsky on realizations of 1-motives. Thirdly, we verify a conjecture of Deligne on extensions of 1-motives in the category of mixed realizations for those extensions that are effective in Nori's sense

The Neron-Severi group of a proper seminormal complex variety

We prove a Lefschetz (1,1)-Theorem for proper seminormal varieties over the complex numbers. The proof is a non-trivial geometric argument applied to the isogeny class of the Lefschetz 1-motive associated to the mixed Hodge structure on H^2.Comment: 16 pages; Mathematische Zeitschrift (2008

Impacts of atmospheric rivers on precipitation in Southern South America

This study quantifies the impact of atmospheric rivers (ARs) on precipitation in southern South America. An AR detection algorithm was developed based on integrated water vapor transport (IVT) from 6-hourly CFSR reanalysis data over a 16-yr period (2001-16). AR landfalls were linked to precipitation using a comprehensive observing network that spanned large variations in terrain along and across the Andes from 27° to 55°S, including some sites with hourly data. Along the Pacific (west) coast, AR landfalls are most frequent between 38° and 50°S, averaging 35-40 days yr-1. This decreases rapidly to the south and north of this maximum, as well as to the east of the Andes. Landfalling ARs are more frequent in winter/spring (summer/fall) to the north (south) of ~43°S. ARs contribute 45%-60% of the annual precipitation in subtropical Chile (37°-32°S) and 40%-55% along the midlatitude west coast (37°-47°S). These values significantly exceed those in western North America, likely due to the Andes being taller. In subtropical and midlatitude regions, roughly half of all events with top-quartile precipitation rates occur under AR conditions. Median daily and hourly precipitation in ARs is 2-3 times that of other storms. The results of this study extend knowledge of the key roles of ARs on precipitation, weather, and climate in the South American region. They enable comparisons with other areas globally, provide context for specific events, and support local nowcasting and forecasting.Fil: Viale, Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Regional de Investigaciones Cientifícas y Tecnológicas; Argentina. Universidad de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Valenzuela, Raúl. Universidad de Chile; ChileFil: Garreaud, René D.. Universidad de Chile; ChileFil: Ralph, F. Martin. University of California at San Diego; Estados Unido

Association of candidate gene polymorphisms with milk technological traits, yield, composition, and somatic cell score in Italian Holstein-Friesian sires

open6siAdvances in DNA-based marker technology have enabled the identification of genomic regions underlying complex phenotypic traits in livestock species. The incorporation of detected quantitative trait loci into genetic evaluation provides great potential to enhance selection accuracies, hence expediting the genetic improvement of economically important traits. The objective of the present study was to investigate 96 single nucleotide polymorphisms (SNP) located in 53 candidate genes previously reported to have effects on milk production and quality traits in a population of highly selected Holstein-Friesian bulls. A total of 423 semen samples were used to genotype the bulls through a custom oligo pool assay. Forty-five SNP in 32 genes were found to be associated with at least 1 of the tested traits. Most significant and favorable SNP trait associations were observed for polymorphisms located in CCL3 and AGPAT6 genes for fat yield (0.037 and 0.033 kg/d, respectively), DGKG gene for milk yield (0.698 kg/d), PPARGC1A, CSN1S1, and AGPAT6 genes for fat percentage (0.127, 0.113, and 0.093%, respectively), GHR gene for protein (0.064%) and casein percentage (0.053%), and TLR4 gene for fat (0.090%), protein (0.066%), and casein percentage (0.050%). Somatic cell score was favorably affected by GHR (−0.095) and POU1F1 (−0.137), and interesting SNP-trait associations were observed for polymorphisms located in CSN2, POU1F1, and AGPAT6 genes for rennet coagulation time (−0.592, −0.558, and −0.462 min, respectively), and GHR and CSN2 genes for curd firmness 30 min after rennet addition (1.264 and 1.183 mm, respectively). In addition to the influence of individual SNP, the effects of composite genotypes constructed by grouping SNP according to their individual effects on traits considered in the analysis were also examined. Favorable and significant effects on milk traits were observed for 2 composite genotypes, one including 10 SNP and the other 4 SNP. The former was associated with an increase of milk (0.075 kg/d), fat (0.097 kg/d), protein (0.083 kg/d), and casein yields (0.065 kg/d), and the latter was associated with an increase of fat (0.244%), protein (0.071%), and casein percentage (0.047%). Although further research is required to validate the identified SNP loci in other populations and breeds, our results can be considered as a preliminary foundation for further replication studies on gene-assisted selection programs.openViale, E.; F., Tiezzi; Maretto, F.; De Marchi, M.; Penasa, M.; Cassandro, M.Viale, E.; Tiezzi, F.; Maretto, F.; De Marchi, M.; Penasa, M.; Cassandro, M

An evidence-based multidisciplinary approach focused at creating algorithms for targeted therapy of bsis, cutis, and ciais caused by enterobacterales in critically ill adult patients

Prompt implementation of appropriate targeted antibiotic therapy represents a valuable approach in improving clinical and ecological outcome in critically septic patients. This multidisciplinary opinion article focused at developing evidence-based algorithms for targeted antibiotic therapy of bloodstream (BSIs), complicated urinary tract (cUTIs), and complicated intrabdominal infections (cIAIs) caused by Enterobacterales. The aim was to provide a guidance for intensive care physicians either in appropriately placing novel antibiotics or in considering strategies for sparing the broadest-spectrum antibiotics. A multidisciplinary team of experts (one intensive care physician, one infectious disease consultant, one clinical microbiologist and one MD clinical pharmacologist), performed several rounds of assessment to reach agreement in developing six different algorithms according to the susceptibility pattern (one each for multi-susceptible, extended-spectrum beta-lactamase-producing, AmpC beta-lactamase-producing, Klebsiella pneumoniae carba-penemase (KPC)-producing, OXA-48-producing, and Metallo-beta-lactamase (MBL)-produ-cing Enterobacterales). Whenever multiple therapeutic options were feasible, a hierarchical scale was established. Recommendations on antibiotic dosing optimization were also pro-vided. In order to retrieve evidence-based support for the therapeutic choices proposed in the algorithms, a comprehensive literature search was performed by a researcher on PubMed-MEDLINE from inception until March 2021. Quality and strength of evidence was established according to a hierarchical scale of the study design. Only articles published in English were included. It is expected that these algorithms, by allowing prompt revision of antibiotic regimens whenever feasible, appropriate place in therapy of novel beta-lactams, implementation of strategies for sparing the broadest-spectrum antibiotics, and pharmacoki-netic/pharmacodynamic optimization of antibiotic dosing regimens, may be helpful either in improving clinical outcome or in containing the spread of antimicrobial resistance

A quantum trajectory description of decoherence

A complete theoretical treatment in many problems relevant to physics, chemistry, and biology requires considering the action of the environment over the system of interest. Usually the environment involves a relatively large number of degrees of freedom, this making the problem numerically intractable from a purely quantum-mechanical point of view. To overcome this drawback, a new class of quantum trajectories is proposed. These trajectories, based on the same grounds as Bohmian ones, are solely associated to the system reduced density matrix, since the evolution of the environment degrees of freedom is not considered explicitly. Within this approach, environment effects come into play through a time-dependent damping factor that appears in the system equations of motion. Apart from their evident computational advantage, this type of trajectories also results very insightful to understand the system decoherence. In particular, here we show the usefulness of these trajectories analyzing decoherence effects in interference phenomena, taking as a working model the well-known double-slit experiment.Comment: 8 pages, 3 figure

A Proof of Concept of the Usefulness of a TDM-Guided Strategy for Optimizing Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Ampicillin-Based Regimens in a Case Series of Patients with Enterococcal Bloodstream Infections and/or Endocarditis

(1) Objective: To describe the usefulness of a real-time therapeutic drug monitoring (TDM)-based strategy for optimizing pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) ampicillin-based regimens in a case series of patients affected by suspected or documented enterococcal bloodstream infections (BSIs) and/or infective endocarditis (IE). (2) Methods: Patients treated with CI ampicillin-based regimens for documented or suspected enterococcal BSI/IE who underwent real-time therapeutic drug monitoring (TDM)-based expert clinical pharmacological advice (ECPA) between June 2021 and May 2022 were retrospectively assessed. Ampicillin concentrations were determined at steady state, and the free fraction (fC(ss)) was calculated according to a plasma protein binding of 20%. The fC(ss)/MIC ratio was selected as the PD parameter for ampicillin efficacy and was defined as optimal for values between 4 and 8. The requirement for TDM-guided ampicillin dosing adjustments was assessed. (3) Results: Data for 12 patients with documented (n = 10) or suspected (n = 2) enterococcal infections (7 with BSIs and 5 with IE) were retrieved. The ampicillin PK/PD target was optimal over time in all of the 10 documented infections. None of the enterococcal BSIs persisted. Following the first real-time TDM-based ECPA, ampicillin dosage was decreased by >50% in 11 out of 12 patients (91.7%). (4) Conclusions: CI may be helpful in attaining aggressive ampicillin PK/PD targets in patients affected by enterococcal BSIs and/or IE. Administration of CI ampicillin after loading coupled with real-time TDM-based ECPA could be a valuable strategy for managing enterococcal infections

Screening for carriage of carbapenem-resistant Enterobacteriaceae in settings of high endemicity: A position paper from an Italian working group on CRE infections

A variety of national and international guidelines exist around the management of carbapenem resistant Enterobacteriaceae (CREs), but some of these are several years old and do not reflect current epidemiology and they also do not necessarily give pragmatic advice around active surveillance of CREs in countries with a high burden of cases and limited resources. This paper aims to provide a best practice position paper to guide active surveillance in a variety of scenarios in these settings, and discusses which patients should be screened, what methods could be used for screening, and how results might influence infection prevention interventions