多成分反応を利用した高付加価値ヘテロ環化合物の効率的合成法に関する研究

九州工業大学博士学位論文（要旨）学位記番号：工博甲第436号 学位授与年月日：平成29年3月24

DATA Analytics of Agriculture Production, Wages and Income in Rural Areas of India using Big Data and Python Matplot Lib

Agriculture Sector is the major contribution in GDP growth rate of India and Most of the Rural India it will become major resource of Income generator it contains different sectors like paddy, poultry, fisheries, Milk, and other crops. In this paper we studied general, commercial, dairy and other related Agricultural out comes and their Incomes and wages. In this paper we are performing different Data Analytics by taking parameters Daily wages, Income and production of Rural India. In this we are using Big Data Hive and Python Matplotlib to produce Graphical Analytical Reports. and finding results of different crops and daily wages of rural workers. The results we are finding year of production, crop wise production, crop wise and sector wise wages and Income of different crops. In this paper we collected Data and sample Analytical Reports from Agriculture Statistics Ministry of Agriculture, Co operation & Farmers Welfare and Data.gov.in . we are revealing different Analytical Reports regarding wages, Income and Production

Altered bactericidal activity aginst staphylococcus aureus in tuberculous bronchoalveolr lavage fluids

Altered bactericidal activity against Staphylococcus aureus in tuberculous bronchoalveolar lavage fluids. P. Selvaraj, N. Venkataprasad, V.K. Vijayan, P.R. Narayanan. ©ERS Journals Ltd 1994. ABSTRACT: We wished to evaluate the pulmonary defence capacity against common bacterial infections in patients with pulmonary tuberculosis. Bactericidal activity against Staphylococcus aureus of bronchoalveolar lavage fluids (cell-free supernatants) of patients with active (n=13) and inactive pulmonary tuberculosis (n=8), and normal individuals (n=6), were studied. The 2 and 4 h bactericidal activities were higher than the 0 h activity in lavage fluids of healthy subjects and patients with inactive pulmonary tuberculosis. Active tuberculous lavage fluids were equally competent in their bactericidal activity against S. aureus at 0 and 2 h, but a reduced S. aureus hilling was seen at 4 h of incubation. Estimation of total phospholipid levels revealed no significant difference between the various lavage fluids. This reduced hilling of S. aureus showed a relationship with the cellular components (lymphocytes and macrophages) of active tuberculous lavage fluids. A reduced hilling was associated with no lymphocytic alveolitis, and an increased hilling with lymphocytic alveolitis. This study suggests that alveolar lining material of patients with active pulmonary tuberculosis has less bactericidal activity against bacterial infections, such as S. aureus

Procoagulant activity of bronchoalveolar lavage fluids taken from the site of tuberculous lesions

Procoagulant activity of bronchoalveolar lavage fluids taken from the site of tuberculous lesions. P. Selvaraj, N. Venkataprasad, V.K. Vijayan, R Prabhakar, P.R Narayanan. ©ERS Journals Ltd 1991. ABSTRACT: We wanted to determine the procoagulant activity (PCA) of bronchoalveolar lavage fluids, in order to understand the macrophage-mediated lung injury at the site of tuberculous lesion. Alveolar lavage fluids taken from the site of a lesion (radiologically abnormal site (RAS)) and an unaffected site (radiologically normal site (RNS)) of active pulmonary tuberculosis (TB) patients (n=7) and inactive (cured) patients (n=9) were studied for their PCA producing potential. The observed results were not significant using Mann-Whitney test, and thus all increases/decreases reported below are trends/ tendencies only. An increased PCA was seen in 4 out of 7 cell-free lavage supernatants of active- TB taken from the site of lesion (RAS), compared to only 1 out of 9 in inactive- TB. The PCA producing potential of the alveolar macrophages of RAS and RNS of active-TB patients was enhanced when the alveolar macrophages were cocultured with autologous peripheral blood lymphocytes under in vitro condition. Stimulation with purified protein derivative (PPD) of M. tuberculosis showed a variable (increased or decreased) PCA production. Peripheral blood monocytes and total mononuclear cells (monocytes + lymphocytes) of active-TB patients stimulated with or without PPD showed increased PCA production, compared with normal individuals and inactive-TB patients. The present study suggests that increased production of PCA by the alveolar macrophages, in collaboration with lymphocytes and other cells at the site of tuberculous lesions will result in fibrin formation. The deposition of fibrin in the alveoli may lead to further lung injury

Alveolar macrophages in patients with pulmonary tuberculosis

Total and HLA-DR positive alveolar macrophages were enumerated in the broncho-alveolar lavage fluids of active pulmonary tuberculosis, inactive pulmonary tuberculosis (treated cases), nontuberculous lung disease patients and normal healthy individuals. A significantly increased number of macrophages was found in the patient groups than the normal individuals: however, there was no difference in HLA-DR positive cells. Among the different patient groups, smokers had more macrophages as well as more HLA-DR positive macrophages than non-smokers and normal subjects Total number of alveolar macrophages of the active tuberculosis non-smoker group was significantly higher than the inactive tuberculosis non-smoker group and normal individuals. On the contrary, a slightly decreased number of HLA-DR positive cells was seen in the non-smoker group of active-TB patients. The present study suggests that infection and smoking induce the accumulation of macrophages in the lung. The implication of these findings in relation to tuberculosis is discussed

MAP REDUCE USING HADOOP FRAMEWORK

This paper describes how Hadoop Frame work was used to process large vast of data., in real time fault tolerant systems and how cluster nodes are created and Replica of data nodes to overcome loss of data. In this paper we focus on the map reducer job , splits the input data-set into independent chunks which are processed by the map tasks in a completely parallel manner

Implications and consequences of ferromagnetism universally exhibited by inorganic nanoparticles

Occurrence of surface ferromagnetism in inorganic nanoprticles as a universal property not only explains many of the unusual magnetic features of oxidic thin films, but also suggests its possible use in creating new materials, as exemplified by multiferroic BaTiO3 nanoparticles. While the use of Mn-doped ZnO and such materials in spintronics appears doubtful, it is possible to have materials exhibiting coexistence of (bulk) superconductivity with (surface) ferromagnetism.Comment: 11 pages, 3 figures, 1 tabl

Immunodominant PstS1 antigen of mycobacterium tuberculosis is a potent biological response modifier for the treatment of bladder cancer

BACKGROUND: Bacillus Calmette Guérin (BCG)-immunotherapy has a well-documented and successful clinical history in the treatment of bladder cancer. However, regularly observed side effects, a certain degree of nonresponders and restriction to superficial cancers remain a major obstacle. Therefore, alternative treatment strategies are intensively being explored. We report a novel approach of using a well defined immunostimulatory component of Mycobacterium tuberculosis for the treatment of bladder cancer. The phosphate transport protein PstS1 which represents the phosphate binding component of a mycobacterial phosphate uptake system is known to be a potent immunostimulatory antigen of M. tuberculosis. This preclinical study was designed to test the potential of recombinant PstS1 to serve as a non-viable and defined immunotherapeutic agent for intravesical bladder cancer therapy. METHODS: Mononuclear cells (PBMCs) were isolated from human peripheral blood and stimulated with PstS1 for seven days. The activation of PBMCs was determined by chromium release assay, IFN-γ ELISA and measurement of lymphocyte proliferation. The potential of PstS1 to activate monocyte-derived human dendritic cells (DC) was determined by flow cytometric analysis of the marker molecules CD83 and CD86 as well as the release of the cytokines TNF-α and IL-12. Survival of presensitized and intravesically treated, tumor-bearing mice was analyzed by Kaplan-Meier curve and log rank test. Local and systemic immune response in PstS1-immunotherapy was investigated by anti-PstS1-specific ELISA, splenocyte proliferation assay and immunohistochemistry. RESULTS: Our in vitro experiments showed that PstS1 is able to stimulate cytotoxicity, IFN-γ release and proliferation of PBMCs. Further investigations showed the potential of PstS1 to activate monocyte-derived human dendritic cells (DC). In vivo studies in an orthotopic murine bladder cancer model demonstrated the therapeutic potential of intravesically applied PstS1. Immunohistochemical analysis and splenocyte restimulation assay revealed that local and systemic immune responses were triggered by intravesical PstS1-immunotherapy. CONCLUSION: Our results demonstrate profound in vitro activation of human immune cells by recombinant PstS1. In addition, intravesical PstS1 immunotherapy induced strong local and systemic immune responses together with substantial anti-tumor activity in a preclinical mouse model. Thus, we have identified recombinant PstS1 antigen as a potent immunotherapeutic drug for cancer therapy