2,671 research outputs found

    Teaching Scenario-Based Planning for Sustainable Landscape Development: An Evaluation of Learning Effects in the Cagliari Studio Workshop

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    This paper investigates the contributions of an intensive educational workshop to advance students’ understanding and skills for collaborative, scenario-based landscape planning. The research design involves a case study workshop with thirty international students and several regional experts as well as a multi-stage, in-process evaluation. The workshop resulted in six different alternative futures for the region of Cagliari, Italy, and a seventh combined version that was considered best by regional reviewers. The students’ learning evaluation showed substantial advances in their relevant understanding and skills. Key aspects of the workshop pedagogy and the evaluation are discussed, and recommendations for future applications presented.Studienstiftung des Deutschen VolkesDAADDF

    Pancreas-Targeted NIR Fluorophores for Dual-Channel Image-Guided Abdominal Surgery

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    Objective: Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas imaging to avoid the intraoperative pancreatic injury. Design: After initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 μmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm NIR fluorophores were employed for dual-channel FLARE™ imaging in pigs: 2 μmol of ZW800-1 for vessels and kidney, 1 μmol of ZW800-3C for lymph nodes, and 2 μmol of ESNF31 for adrenal glands. Results: T700-F demonstrated the highest signal to background ratio (SBR), with peak SBR at 4 h postinjection in mice. In pigs, T700-F produced an SBR ≥ 2 against muscle, spleen, and lymph nodes for up to 8 h after a single intravenous injection. The combination of T700-F with each 800 nm NIR fluorophore provided simultaneous dual-channel intraoperative imaging of pancreas with surrounding organs in real time. Conclusion: Pancreas-targeted NIR fluorophores combined with the FLARE dual-channel imaging system enable the real-time intraoperative pancreas imaging which helps surgeons perform safer and more curative abdominal surgeries

    EIFIS: a modular extreme integral field spectrograph for the 10.4m GTC

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    EIFIS (Extreme Integral FIeld Spectrograph) is a modular integral field spectrograph, based on image slicers, and makes use of new, large format detectors. The concept is thought to cover the largest possible field of view while producing spectroscopy over the complete optical range (3 000 - 10 000 \r{A}) at a medium resolving power of about 2400. In the optimal concept, each module covers a field of view of 38" x 38" with 0.3" spaxels, which is fed into a double spectrograph with common collimator optics. The blue arm covers the spectral range between 3000 and 5600 \r{A} and the red arm between 5400 and 10100 \r{A}, allowing for an overlap range. The spectra are imaged onto 9.2k x 9.2k detectors using a double pseudoslit. The proposed design for the 10.4m Gran Telescopio Canarias uses a total of 6 such modules to cover a total of 2.43 square arcminutes. Here we will present the conceptual design of the instrument and a feasibility study of the optical and mechanical design of the spectrographs. We discuss the limitations and alternative designs and its potential to produce leading edge science in the era of extremely large telescopes and the James Webb Space Telescope.Comment: Submitted to the Proceedings of the SPIE, Astronomical Telescopes and Instrumentatio

    Hawaiʻi Coral Disease database (HICORDIS):species-specific coral health data from across the Hawaiian archipelago

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    AbstractThe Hawaiʻi Coral Disease database (HICORDIS) houses data on colony-level coral health condition observed across the Hawaiian archipelago, providing information to conduct future analyses on coral reef health in an era of changing environmental conditions. Colonies were identified to the lowest taxonomic classification possible (species or genera), measured and assessed for visual signs of health condition. Data were recorded for 286,071 coral colonies surveyed on 1819 transects at 660 sites between 2005 and 2015. The database contains observations for 60 species from 22 genera with 21 different health conditions. The goals of the HICORDIS database are to: i) provide open access, quality controlled and validated coral health data assembled from disparate surveys conducted across Hawaiʻi; ii) facilitate appropriate crediting of data; and iii) encourage future analyses of coral reef health. In this article, we describe and provide data from the HICORDIS database. The data presented in this paper were used in the research article “Satellite SST-based Coral Disease Outbreak Predictions for the Hawaiian Archipelago” (Caldwell et al., 2016) [1]

    Characterizing the limited use of point-of-care ultrasound in Colombian emergency medicine residencies

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    Background: Emergency medicine (EM) is a growing specialty in Colombia with five residency programs in the country. EM leadership is interested in incorporating point-of-care (POC) ultrasound into a standardized national EM residency curriculum. This study is a nationwide survey of Colombian EM residents designed to explore the current state of POC ultrasound use within EM residencies and examine specific barriers preventing its expansion. Methods: We conducted a mix-methodology study of all available current EM residents in the five EM residencies in Colombia. The quantitative survey assessed previous ultrasound experience, current use of various applications, desire for further training, and perceived barriers to expanded use. Focus group discussions (FGDs) were conducted with current EM residents to gather additional qualitative insight into their practice patterns and perceived barriers to clinician-performed ultrasound. Results: Sixty-nine EM residents completed the quantitative survey, a response rate of 85% of all current EM residents in Colombia; 52% of resident respondents had previously used ultrasound during their training. Of these, 58% indicated that they had performed <10 scans and 17% reported >40 scans. The most frequently used applications indicated by respondents were trauma, obstetrics, and procedures including vascular access. A quarter indicated they had previously received some ultrasound training, but almost all expressed an interest in learning more. Significant barriers included lack of trained teachers (indicated by 78% of respondents), absence of machines (57%), and limited time (41%). In FGDs, the barriers identified were inter-specialty conflicts over the control of ultrasonography, both institutionally and nationally, and program-specific curriculum decisions to include POC ultrasound. Conclusion: While currently limited in their access, EM residents in Colombia have a strong interest in integrating POC ultrasound into their training. Current barriers to expanded use include traditional barriers such as a lack of equipment seen in many developing countries, as well as inter-specialty conflicts typical of developed countries. Further collaboration is underway to help overcome these obstacles and integrate POC ultrasound into Colombian EM residency training. © 2014 Henwood et al.; licensee Springer

    Dolabelladienols A–C, New Diterpenes Isolated from Brazilian Brown Alga Dictyota pfaffii

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    [Abstract:]The marine brown alga Dictyota pfaffii from Atol das Rocas, in Northeast Brazil is a rich source of dolabellane diterpene, which has the potential to be used in future antiviral drugs by inhibiting reverse transcriptase (RT) of HIV-1. Reexamination of the minor diterpene constituents yielded three new dolabellane diterpenes, (1R*,2E,4R*,7S,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (1), (1R*,2E,4R*,7R*,10S*,11S*,12R*)10,18-diacetoxy-7-hydroxy-2,8(17)-dolabelladiene (2), (1R*,2E,4R*,8E,10S*,11S,12R*)10,18-diacetoxy-7-hydroxy-2,8-dolabelladiene (3), termed dolabelladienols A–C (1–3) respectively, in addition to the known dolabellane diterpenes (4–6). The elucidation of the compounds 1–3 was assigned by 1D and 2D NMR, MS, optical rotation and molecular modeling, along with the relative configuration of compound 4 and the absolute configuration of 5 by X-ray diffraction. The potent anti-HIV-1 activities displayed by compounds 1 and 2 (IC50 = 2.9 and 4.1 μM), which were more active than even the known dolabelladienetriol 4, and the low cytotoxic activity against MT-2 lymphocyte tumor cells indicated that these compounds are promising anti-HIV-1 agents.Brasil. Conselho Nacional de Desenvolvimento Científico e Tecnológico; 490425/2010-0Brasil. Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro ; E-26/103.176/2011Ministerio de Economia y Competitividad; AGL2012-12266-C0

    A saúde da mulher e seus (inúmeros) desafios na contracepção

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    This article aimed to obtain information about the current sociocultural behavioral barriers and investigate the variables related to the use of contraceptives. Integrative literature review through the Virtual Health Library platform carried out from May to July 2022. Fifteen articles that met the determined inclusion criteria were analyzed. Among the selected articles, national and American studies covered 26.6% of the theoretical framework used and the focuses mainly emphasized social factors, attributed as determinants for the choice and correct use of contraceptive methods. There was a need to develop reproductive planning strategies in health services, which encourage the involvement and co-responsibility of men in the couple's reproductive health to reduce the gender disparity accentuated over the years by exclusively female responsibility for fertility.O presente artigo teve como objetivo obter informações sobre as barreiras comportamentais socioculturais vigentes e investigar as variáveis relacionadas ao uso de anticoncepcionais. Revisão integrativa da literatura através da plataforma Biblioteca Virtual em Saúde realizada de maio a julho de 2022. Foram analisados quinze artigos que atenderam aos critérios de inclusão determinados. Dentre os artigos selecionados, os estudos nacionais e estadounidenses contemplaram 26,6% do referencial teórico utilizado e os enfoques enfatizaram, principalmente, os fatores sociais, atribuídos como determinantes para a escolha e uso correto dos métodos contraceptivos. Constatou-se a necessidade de desenvolvimento de estratégias de planejamento reprodutivo nos serviços de saúde, que estimulem o envolvimento e a corresponsabilização do homem na saúde reprodutiva do casal, de forma a reduzir a disparidade de gêneros acentuada ao longo dos anos pela responsabilização exclusivamente feminil sobre a fecundidade

    Estágio supervisionado em cursos de licenciatura: reflexões de docentes formadores / Study supervised in licensing courses: reflections of teaching teachers

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    Apresentamos nesse texto, as análises e reflexões realizadas a partir da nossa experiência e vivência como professores condutores do Estágio Supervisionado em cursos de licenciatura. Para tanto, realizamos uma abordagem das questões legislativas da formação de professores que envolvem o Estágio Supervisionado e das concepções de diferentes pesquisadores do campo educacional. Discutimos sobre alguns aspectos desafiadores da profissionalização do professor, enfocando a importância da indissociabilidade entre a teoria e a prática
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