Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Universal DNA methylation age across mammalian tissues

DATA AVAILABILITY STATEMENT : The individual-level data from the Mammalian Methylation Consortium can be accessed from several online locations. All data from the Mammalian Methylation Consortium are posted on Gene Expression Omnibus (complete dataset, GSE223748). Subsets of the datasets can also be downloaded from accession numbers GSE174758, GSE184211, GSE184213, GSE184215, GSE184216, GSE184218, GSE184220, GSE184221, GSE184224, GSE190660, GSE190661, GSE190662, GSE190663, GSE190664, GSE174544, GSE190665, GSE174767, GSE184222, GSE184223, GSE174777, GSE174778, GSE173330, GSE164127, GSE147002, GSE147003, GSE147004, GSE223943 and GSE223944. Additional details can be found in Supplementary Note 2. The mammalian data can also be downloaded from the Clock Foundation webpage: https://clockfoundation.org/MammalianMethylationConsortium. The mammalian methylation array is available through the non-profit Epigenetic Clock Development Foundation (https://clockfoundation.org/). The manifest file of the mammalian array and genome annotations of CpG sites can be found on Zenodo (10.5281/zenodo.7574747). All other data supporting the findings of this study are available from the corresponding author upon reasonable request. The chip manifest files, genome annotations of CpG sites and the software code for universal pan-mammalian clocks can be found on GitHub95 at https://github.com/shorvath/MammalianMethylationConsortium/tree/v2.0.0. The individual R code for the universal pan-mammalian clocks, EWAS analysis and functional enrichment studies can be also found in the Supplementary Code.SUPPLEMENTARY MATERIAL 1 : Supplementary Tables 1–3 and Notes 1–6.SUPPLEMENTARY MATERIAL 2 : Reporting SummarySUPPLEMENTARY MATERIAL 3 : Supplementary Data 1–14.SUPPLEMENTARY MATERIAL 4 : Supplementary Code.Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.https://www.nature.com/nataginghj2024Zoology and EntomologySDG-15:Life on lan

ИССЛЕДОВАНИЕ ВЛИЯНИЯ ГЛУБИНЫ ПОДЗЕМНЫХ ВЗРЫВОВ НА ВЫДЕЛЕНИЕ СЕЙСМИЧЕСКОЙ ЭНЕРГИИ ДИНАМИЧЕСКИХ ЯВЛЕНИЙ

Underground mining, which is carried out in the fields for the purpose of extraction of solid minerals, violate the continuity of the rock mass. Natural redistributed stress state, forming areas of stress concentration, the current close loop around the perimeter of the outcrops of structural elements used geotechnologies. Technological and mass explosions initiate the release of seismic energy in the array and provoke dynamic manifestations of rock pressure, which occur instantly. After opening the ore Deposit by mining, the massif with potential energy to a greater extent begins to activate with the release of significant amounts of kinetic energy. During underground explosions the interrelation of the released total seismic energy of dynamic phenomena and seismic energy of explosions at initiation of charges of VV on various depth is established. A method of unloading rockburst-hazardous areas of mines.Подземные горные работы, которые проводятся на месторождениях с целью до бычи твердых полезных ископаемых, нарушают сплошность массива горных по род. Перераспределяется природное напряженное состояние, формируются зоны концентрации напряжений, действующие вблизи контура по всему периметру об нажений конструктивных элементов применяемых геотехнологий. Технологиче ские и массовые взрывы инициируют выделение сейсмической энергии в массиве и провоцируют динамические проявления горного давления, которые происходят мгновенно. После вскрытия горными выработками рудного участка на место рождении массив в большей степени обладающий потенциальной энергией, начи нает активизироваться с выделением значительных объемов кинетической энер гии. При проведении подземных взрывов установлена взаимосвязь выделяемой сум марной сейсмической энергии динамических явлений и сейсмической энергии взры вов при инициирование зарядов ВВ на различной глубине. Представлен способ раз грузки удароопасных участков месторождений

Биогенные элементы атмосферных выпадений и влияние субсредиземноморских пушистодубовых лесных сообществ на изменение химического состава атмосферных осадков

In this work, a study of the biogenic composition of atmospheric precipitation and its change during the passage through the crowns of trees of a downy oak forest was carried out. First of all, the content of rainwater-soluble compounds of all the considered elements in rainwater under the forest canopy was higher than in rainwater in an open area. It was revealed that the main forms of nitrogen in the atmospheric fallout were nitrates and ammonium. The average concentrations of nitrogen anions in rainwater collected under the canopy were higher than in rainwater collected in the open area. The proportion of nitrite nitrogen in rainwater under the canopy was 6% higher than in rainwater collected in the open area. Simultaneously with the increase in the proportion of nitrite nitrogen, nitrate nitrogen decreased. For all considered biogenic substances, an increase in their content was observed in the warm period of the year. We found an inverse relationship between the concentration of inorganic nitrogen and phosphorus in precipitation and the relative air humidity and wind speed. It was established that the pH of precipitation falling under the crowns of trees was lower than the pH of precipitation in the open area. It was revealed that the increase in the concentration of biogenic elements was in accordance with the phase of plant development during the growing season.В данной работе проведено исследование биогенного состава атмосферных осадков и его изменения при прохождении через кроны деревьев пушистодубового леса. Прежде всего, содержание растворимых в дождевой воде соединений всех рассматриваемых элементов в дождевой воде под пологом леса было выше, чем в дождевой воде на открытой местности. Выявлено, что основными формами азота в атмосферных выпадениях являются нитраты и аммоний. Средние концентрации анионов азота в дождевой воде, собранной под кронами, были выше, чем в дождевой воде, собранной на открытой местности. Доля нитритного азота в дождевой воде под кронами была на 6% выше, чем в дождевой воде, собранной на открытой местности. Одновременно с увеличением доли нитритного азота нитратный азот уменьшался. Для всех рассматриваемых биогенных веществ наблюдалось увеличение их содержания в теплый период года. Обнаружена обратная зависимость концентрации неорганического азота и фосфора в осадках от относительной влажности воздуха и скорости ветра. Установлено, что рН осадков, выпадающих под кронами деревьев, ниже, чем рН осадков на открытой местности. Выявлено, что увеличение концентрации биогенных элементов происходило в соответствии с фазой развития растений в течение вегетационного периода

Resource queuing systems as models of wireless communication systems

The article presents an overview of the resource queuing systems used for modeling of a wide class of real systems with admittedly limited resources. Despite the objective importance of studying of such systems, there have been very few works devoted to their analysis until recently, which was due to the complexity of constructing a random process to describe their functioning and, accordingly, of obtaining the numerical results. However, in recent years, there has been a significant shift in the study of the resource systems - new methods for their analysis have been proposed, which made it possible to construct recursive algorithms suitable for the numerical calculations. In this regard, the current review reflects only a part of the previously obtained results, namely, it considers the resource systems without waiting space with exponentially distributed service time. The authors consider the models of wireless communication systems based on resource queuing systems, expressions for estimating the main probabilistic, and temporal characteristics and algorithms for their calculation. © 2018 Federal Research Center Computer Science and Control of Russian Academy of Sciences

Модель предоставления услуги мультивещания точкой доступа mmWave

The model of an access point in the millimeter wavelength range serving requests for the establishment of sessions for the provision of services both on the principle of “point-to - point” and on the principle of “point-to-many points” is investigated in work. The model considers a random amount of network resource requirements, depending on the location of the user's device, namely, on the distance between the receiver and transmitter. Besides, the model considers the possibility of temporary disruption of direct visibility between devices due to the so-called blockers, which include people, lighting pillars, cars, buildings, etc. Such a violation arising in the case of the movement of objects and transceivers, leads to necessity to increase the volume of resources required to service the user's request, during the whole time of lack of direct visibility. As the main indicators of system performance, the probabilities of a reset of requests for the establishment of unicast and multicast connections, as well as the resource utilization factor of the access point are considered. The reset of request for establishment of connection happens either at the time of receipt of inquiry in the absence of a system resource, necessary for its maintenance, or at the time of emergence of the lock of direct visibility at impossibility to increase the resource which is already allocated for servicing the request by the required amount.В работе исследована модель точки доступа в миллиметровом диапазоне длин волн, обслуживающей запросы на установление сессий для предоставления услуг как по принципу «точка-точка», так и по принципу «точкамного точек». В модели учитывается случайный объем требований к ресурсам сети, зависящий от расположения устройства пользователя, а именно, от расстояния между приёмником и передатчиком. Кроме того, в модели учитывается возможность временного нарушения прямой видимости между устройствами из-за так называемых блокираторов, к которым можно отнести людей, столбы линий освещения, автомобили, здания и т.д. Такое нарушение, возникающее в случае движения объектов и приёмо-передающих устройств, приводит к необходимости увеличения объёма ресурса, требуемого для обслуживания запроса пользователя, в течение всего времени отсутствия прямой видимости. В качестве основных показателей производительности системы рассмотрены вероятности сброса запросов на установление одноадресных и многоадресных соединений, а также коэффициент использования ресурсов точки доступа. Сброс запроса на установление соединения происходит либо в момент поступления запроса при отсутствии необходимого для его обслуживания ресурса системы, либо в момент появления блокиратора прямой видимости при невозможности увеличить уже выделенный для обслуживания запроса ресурс на необходимую величину

Support design using unwedge software for mines of nornickel’s polar division

The method of support design using Unwedge software is proposed and substantiated for mines of Nornickel’s Polar Division. The software allows rapid and qualitative stability analysis for roofs and sidewalls in underground excavations, as well as enables competent failure envelope plotting for an excavation or its area with regard to varying geological and geotechnical conditions, which improves safety and efficiency of mining. The article discusses two case-studies. The first event is roof fall along the system of joints in a development drive in the Kholbin Mine. In that case, the quantitative assessment of rock mass quality was never undertaken, thus, the systems of joints, sizes of wedges, contact conditions of joints, etc. were neglected. The second case describes the support design using Unwedge software for an excavation driven in rock mass of ramp RSH1/6-2 in the Oktyabrsky Mine. The excavation was supported as per the Unwedge design. The calculated safety factors for each rock wedge are higher than 2, which complies with Russian regulatory documents. The excavation stability is predicted for the operational period at the minimum risk of rock falls. © 2019, Publishing house Mining book. All rights reserved

Resource queuing systems with general service discipline

The article gives an overview of resource queuing systems with the concentration on the methods of their investigation. A valuable part of the article is devoted to the method, which leads to a significant simplification of the system analysis while maintaininghigh accuracy of the estimate, and in some cases without any loss of accuracy. Simplification is to consider a system with random resource amount release at the instant of a customer departure instead of a system with the exact resource amount release equal to the occupied by the customer at the beginning of service. Subsequently, for the case of a Poisson flow of arrivals and exponential service time, the equivalence of the results for the initial and the simplified models was rigorously proved. In addition, a significant part of the paper is devoted to the overview of publications on the recurrent service discipline. © 2019 Federal Research Center "Computer Science and Control" of Russian Academy of Sciences. All rights reserved

КАКИМ БОЛЬНЫМ РАКОМ ЯИЧНИКА ПОКАЗАНА КОМБИНАЦИЯ ТРАБЕКТЕДИНА С ПЕГИЛИРОВАННЫМ ЛИПОСОМАЛЬНЫМ ДОКСОРУБИЦИНОМ

Given the high rate of recurrence of ovarian cancer, the search for new therapeutic strategies are topical issue. According to various studies the effectiveness of drug treatment relapse depends on the platinum-free interval, increasing in proportion to its duration. If therapy is platinum-resistant recurrent ovarian cancer is a standard approach, the treatment of platinum-sensitive recurrent algorithm is not fully defined. Comparison of platinum and non-platinum combinations revealed the advantage of combined platinum- treatment for patients with platinum-free interval of more than 6 months without an increase in life expectancy. Non-platinum combination of trabectedin with pegylated liposomal doxorubicin has shown comparable efficacy with an advantage in overall survival in patients with platinum-free interval of 6–12 months. A platinum-free interval prolongation by the use of non-platinum mode increases the efficiency of subsequent platinum-based therapy, increasing the life expectancy of patients . Currently under study molecular markers and prognostic factors allowing to define a group of patients who have the greatest benefit from the use trabectedin with pegylated liposomal doxorubicin as second-line chemotherapy. Учитывая высокую частоту рецидивирования рака яичника, поиск новых терапевтических стратегий представляется актуальным вопросом. По данным различных исследователей, эффективность лекарственного лечения рецидивов зависит от бесплатинового интервала, возрастая пропорционально его продолжительности. Если терапия платинорезистентных рецидивов рака яичника имеет стандартные подходы, то алгоритм лечения платиночувствительных рецидивов до конца не определен. Сравнение платиновых и неплатиновых комбинаций показало преимущество комбинированного платиносодержащего режима для больных с бесплатиновым интервалом более 6 мес без увеличения продолжительности жизни. Неплатиновая комбинация трабектедина с пегилированным липосомальным доксорубицином продемонстрировала сопоставимую эффективность с преимуществом по общей выживаемости в группе больных с бесплатиновым интервалом 6–12 мес, а пролонгирование бесплатинового интервала путем применения неплатинового режима повышает эффективность последующей платиносодержащей терапии, увеличивая продолжительность жизни больных. В настоящее время проводится исследование молекулярных маркеров и прогностических факторов, позволяющих определить группу больных, получающих наибольшую пользу от назначения трабектедина с пегилированным липосомальным доксорубицином во второй линии химиотерапии.

MEASURING OF AIRWAYS RESISTANCE BASED ON INTERRUPTER TECHNIQUE IN PRE-SCHOOLCHILDREN

Authors give information on limits of population norm for expiratory and inspiratory resistance by the interrupter technique indices (RINTexp and RINTinsp accordingly) in 214 healthy children 3–6 years old. Estimation of RINT was performed with spirograph Super Spiro with MicroRint module. Parameters of RINTexp and RINTinsp are similar in boys and girls. RINTexp depends on height of a child. Information on limits of normal rates is presented in this article, and this data can be used in diagnostics of respiratory pathology. Key words: children, age, resistance of airways, RINT, norm.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(5):30-34