288 research outputs found
Angular distributions of scattered excited muonic hydrogen atoms
Differential cross sections of the Coulomb deexcitation in the collisions of
excited muonic hydrogen with the hydrogen atom have been studied for the first
time. In the framework of the fully quantum-mechanical close-coupling approach
both the differential cross sections for the transitions and
-averaged differential cross sections have been calculated for exotic atom
in the initial states with the principle quantum number at relative
motion energies eV and at scattering angles
. The vacuum polarization shifts of the
-states are taken into account. The calculated in the same approach
differential cross sections of the elastic and Stark scattering are also
presented. The main features of the calculated differential cross sections are
discussed and a strong anisotropy of cross sections for the Coulomb
deexcitation is predicted.Comment: 5 pages, 9 figure
Determination of pulsation periods and other parameters of 2875 stars classified as MIRA in the All Sky Automated Survey (ASAS)
We have developed an interactive PYTHON code and derived crucial ephemeris
data of 99.4% of all stars classified as 'Mira' in the ASAS data base,
referring to pulsation periods, mean maximum magnitudes and, whenever possible,
the amplitudes among others. We present a statistical comparison between our
results and those given by the AAVSO International Variable Star Index (VSX),
as well as those determined with the machine learning automatic procedure of
Richards et al. 2012. Our periods are in good agreement with those of the VSX
in more than 95% of the stars. However, when comparing our periods with those
of Richards et al, the coincidence rate is only 76% and most of the remaining
cases refer to aliases. We conclude that automatic codes require still more
refinements in order to provide reliable period values. Period distributions of
the target stars show three local maxima around 215, 275 and 330 d, apparently
of universal validity, their relative strength seems to depend on galactic
longitude. Our visual amplitude distribution turns out to be bimodal, however
1/3 of the targets have rather small amplitudes (A 2.5) and could
refer to semi-regular variables (SR). We estimate that about 20% of our targets
belong to the SR class. We also provide a list of 63 candidates for period
variations and a sample of 35 multiperiodic stars which seem to confirm the
universal validity of typical sequences in the double period and in the
Petersen diagramsComment: 14 pages, 14 figures, and 8 tables. Accepted to The Astrophysical
Journal Supplement Series, September 201
Suivi thérapeutique de l'imatinib
* Le monitoring (suivi) joue un rôle important pour un traitement et son évaluation - pour autant qu'il se base sur la mesure de marqueurs cliniques adéquats ou de substituts validés.
* Pour ce qui est du traitement d'imatinib, le «therapeutic drug monitoring» (TDM) semble être une option utile pour le contrôle du traitement de la LMC. Il utilise la concentration plasmatique de ce médicament comme marqueur.
* Les concentrations plasmatiques d'imatinib varient considérablement d'un patient à l'autre sous un même schéma posologique, en raison de la variabilité interindividuelle de sa pharmacocinétique. Il a été démontré que l'exposition plasmatique était en corrélation avec le résultat clinique des patients LMC - aussi bien pour la réponse au traitement que pour le profil d'effets indésirables.
* Il n'est pas encore établi si le TDM de l'imatinib doit être utilisé que dans le cas de problèmes cliniques ou si les patients LMC peuvent déjà profiter d'un contrôle préventif systématique «de routine» - de manière à garder la concentration plasmatique dans des marges thérapeutiques. Cela est toujours plus recommandé ces derniers temps.
* Pour répondre à cette question, une étude suisse prospective, randomisée et contrôlée recrute des patients LMC traités par imatinib depuis moins de 5 ans et propose en outre le TDM pour tous les patients en cas de problèmes cliniques.
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* Monitoring spielt eine wichtige Rolle zur Therapieevaluierung und Behandlungsentscheidung - solange es auf der Basis der Messung von entsprechenden klinischen oder validierten Surrogat-Markern stattfindet.
* Im Hinblick auf die Imatinib-Therapie scheint das «Therapeutische Drug-Monitoring» (TDM) ein nützlicher Ansatz zum Therapie-Monitoring der CML-Behandlung zu sein, welches die Plasmakonzentration des Arzneimittels als Marker zur Therapieüberwachung verwendet.
* Imatinib-Plasmakonzentrationen variieren beträchtlich von Patient zu Patient unter dem gleichen Dosierungsschema, aufgrund der interindividuell unterschiedlichen Pharmakokinetik des Arzneimittels. Für die Plasmaexposition wurde gezeigt, dass sie mit dem klinischen Outcome von CML-Patienten korreliert - sowohl im Bezug auf das Therapieansprechen als auch auf das Nebenwirkungsprofil.
* Es ist noch unklar, ob das TDM von Imatinib nur im Falle von klinischen Problemen Verwendung finden sollte oder ob CML-Patienten bereits von einem systematischen, präventiven «Routine»-Monitoring zur Therapieindividualisierung - zur Steuerung der Plasmakonzentration in einen therapeutischen Bereich - profitieren könnten, welches in letzter Zeit immer häufiger empfohlen wird.
* Um diese Fragestellung zu beantworten, nimmt eine prospektive, randomisiert kontrollierte Schweizer Studie CML-Patienten auf, die seit weniger als 5 Jahren mit Imatinib behandelt werden, und bietet das TDM zudem für alle Patienten im Falle von klinischen Problemen an
Hadronic shift in pionic hydrogen
The hadronic shift in pionic hydrogen has been redetermined to be
\,eV by X-ray
spectroscopy of ground state transitions applying various energy calibration
schemes. The experiment was performed at the high-intensity low-energy pion
beam of the Paul Scherrer Institut by using the cyclotron trap and an
ultimate-resolution Bragg spectrometer with bent crystals.Comment: 10 pages, 6 figure
Line shape analysis of the K transition in muonic hydrogen
The K transition in muonic hydrogen was measured with a
high-resolution crystal spectrometer. The spectrum is shown to be sensitive to
the ground-state hyperfine splitting, the corresponding triplet-to-singlet
ratio, and the kinetic energy distribution in the state. The hyperfine
splitting and triplet-to-singlet ratio are found to be consistent with the
values expected from theoretical and experimental investigations and,
therefore, were fixed accordingly in order to reduce the uncertainties in the
further reconstruction of the kinetic energy distribution. The presence of
high-energetic components was established and quantified in both a
phenomenological, i.e. cascade-model-free fit, and in a direct deconvolution of
the Doppler broadening based on the Bayesian approach.Comment: 22 pages, 21 figure
Guidelines for the study of subsidence triggered by hydrocarbon production
This study was carried out by the SEADOG Research Center at Politecnico di Torino (Italy). The purpose of this work was to evaluate which complexity degree would be required to reliably approach a subsidence study for different scenarios. The study was based on sensitivity analyses which were performed using a series of 3D synthetic numerical models of which the structural characteristics and geological and mechanical properties were based on available public data of onshore and offshore hydrocarbon fields in Italy. An array of simulations, both one-way and two-way coupled, were carried out to assess the magnitude and extension of subsidence potentially induced by hydrocarbon production. The results allowed the calculation of subsidence indices defined as the rate of compaction propagation (i.e., the ratio between the maximum surface displacement and the maximum reservoir compaction) and as the rate of volume loss (i.e. the ratio between the volume of the subsidence bowl or cone and the volume variation of the reservoir). These indices together with the degree of the underground systems’ heterogeneity led to the definition of the Intact Rock Qualitative Subsidence Index (IRQSI), upon which the needed complexity degree of a subsidence study can be discerned
Semimechanistic modeling of copeptin and aldosterone kinetics and dynamics in response to rehydration treatment for diabetic ketoacidosis in children
Pharmacolog
Towards a high precision calculation for the pion-nucleus scattering lengths
We calculate the leading isospin conserving few-nucleon contributions to pion
scattering on H, He, and He. We demonstrate that the strong
contributions to the pion-nucleus scattering lengths can be controlled
theoretically to an accuracy of a few percent for isoscalar nuclei and of 10%
for isovector nuclei. In particular, we find the -He scattering length
to be where the uncertainties are
due to ambiguities in the -N scattering lengths and few-nucleon effects,
respectively. To establish this accuracy we need to identify a suitable power
counting for pion-nucleus scattering. For this purpose we study the dependence
of the two-nucleon contributions to the scattering length on the binding energy
of H. Furthermore, we investigate the relative size of the leading two-,
three-, and four-nucleon contributions. For the numerical evaluation of the
pertinent integrals, aMonte Carlo method suitable for momentum space is
devised. Our results show that in general the power counting suggested by
Weinberg is capable to properly predict the relative importance of -nucleon
operators, however, it fails to capture the relative strength of - and
-nucleon operators, where we find a suppression by a factor of 5
compared to the predicted factor of 50. The relevance for the extraction of the
isoscalar -N scattering length from pionic H and He is discussed.
As a side result, we show that beyond the calculation of the -H
scattering length is already beyond the range of applicability of heavy pion
effective field theory.Comment: 24 pages, 14 figures, 10 table
Energy Dependence of the Delta Resonance: Chiral Dynamics in Action
There is an important connection between the low energy theorems of QCD and
the energy dependence of the Delta resonance in pi-N scattering, as well as the
closely related gamma^{*} N -> pi N reaction. The resonance shape is due not
only to the strong pi-N interaction in the p wave but the small interaction in
the s wave; the latter is due to spontaneous chiral symmetry breaking in QCD
(i.e. the Nambu-Goldstone nature of the pion). A brief overview of experimental
tests of chiral perturbation theory and chiral based models is presentedComment: 11 pages, 6 figures, Festschrift for S.N. yan
Clinical usefulness of therapeutic concentration monitoring for imatinib dosage individualization: results from a randomized controlled trial.
PURPOSE: This study assessed whether a cycle of "routine" therapeutic drug monitoring (TDM) for imatinib dosage individualization, targeting an imatinib trough plasma concentration (C min) of 1,000 ng/ml (tolerance: 750-1,500 ng/ml), could improve clinical outcomes in chronic myelogenous leukemia (CML) patients, compared with TDM use only in case of problems ("rescue" TDM).
METHODS: Imatinib concentration monitoring evaluation was a multicenter randomized controlled trial including adult patients in chronic or accelerated phase CML receiving imatinib since less than 5 years. Patients were allocated 1:1 to "routine TDM" or "rescue TDM." The primary endpoint was a combined outcome (failure- and toxicity-free survival with continuation on imatinib) over 1-year follow-up, analyzed in intention-to-treat (ISRCTN31181395).
RESULTS: Among 56 patients (55 evaluable), 14/27 (52 %) receiving "routine TDM" remained event-free versus 16/28 (57 %) "rescue TDM" controls (P = 0.69). In the "routine TDM" arm, dosage recommendations were correctly adopted in 14 patients (median C min: 895 ng/ml), who had fewer unfavorable events (28 %) than the 13 not receiving the advised dosage (77 %; P = 0.03; median C min: 648 ng/ml).
CONCLUSIONS: This first target concentration intervention trial could not formally demonstrate a benefit of "routine TDM" because of small patient number and surprisingly limited prescriber's adherence to dosage recommendations. Favorable outcomes were, however, found in patients actually elected for target dosing. This study thus shows first prospective indication for TDM being a useful tool to guide drug dosage and shift decisions. The study design and analysis provide an interesting paradigm for future randomized TDM trials on targeted anticancer agents
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