COVID 19 in pregnancy: our experience amidst second wave of COVID-19 at a teaching institute

To analyse the obstetrical outcome during second wave of coronavirus disease 2019 (COVID-19) at Level 2 facility. This is a hospital based analytical study conducted at Raj Shree medical and research institute Bareilly. During second wave a total 87 patients presenting to obstetric emergency department, over a period of one month (April 2021 to May 2021). A total of 26 patients were admitted in the hospital. 20 patients were COVID-19 positive and 6 patients were symptomatic with RT-PCR negative report. Out of 20 patients 19 were antenatal case and 1 case was postnatal. There were 2 mortalities among all positive patients. In all COVID-19 positive patients’ majority of the patients were in 26 to 30 years of age (46%). A High proportion presented in third trimester, at the gestation period between 37 to 40 weeks (54%). Around 23% patients had severe symptoms and there were 4 ICU admissions. 65% patients required supplemental oxygen at a rate of >12 l/min. There were a total 2 mortalities; both were in severe category with rapid deterioration. The significant laboratory derangement observed was coagulation profile deranged in 40% cases. COVID-19 second wave was deleterious for obstetric population in an unprecedented manner. A high morbidity and mortality were seen in this duration. Data and evidence which is continuously evolving needs to be shared for global references and knowledge sharing amongst peers

Structural, spectroscopic, electronic, and nonlinear optical behavior investigations of conjugated organic nonlinear optical chalcone derivative 3-(2,3-dichlorophenyl)-1-(pyridine-2-yl)prop-2-en-1-one using DFT

In this paper we have reported the computational studies of structural, spectroscopic and electronic behavior of a chalcone derivative: 3-(2,3- dichlorophenyl )-1-(pyridine-2- yl)prop-2-en-1-one (DCPP) nonlinear optical crystal. The geometry of DCPP molecule have been optimized using density functional theory (DFT) at B3LYP level having extended basis sets 6-311++G(d,p), 6-311+G(d,p), and 6-311G(d,p) with the help of Gaussian 09W program package. The structure parameters calculated with 6-311++G(d,p) basis set have shown best matching with experimental data having  R2 value  equal to 0.99. Taking this optimized geometry FTIR spectra were simulated and analyzed quantitatively with the help of calculated potential energy distribution (PED). For finding the reactivity sites and to understand electronic and optical behavior, natural bond orbital (NBO), the electrostatic potential surface map with isodensity surface, and HOMO-LUMO analysis were also presented. Finally, the nonlinear optical behavior of this calcone derivative was studied by calculating dipole moment (m), polarizability(a) and hyperpolarizability (b) values. The calculated hyperpolarizability btot of DCPP is 17.4593×10-30 esu which is about 90 times greater than urea (β= 0.1947× 10-30 esu). This higher value of hyperpolarizability btot confirms that the present molecule DCPP is a potential candidate for Nonlinear Optical applications

Structural, spectroscopic, electronic, and nonlinear optical behavior investigations of π conjugated organic nonlinear optical chalcone derivative 3-(2,3-dichlorophenyl)-1-(pyridine-2-yl)prop-2-en-1-one using DFT

48-62In this paper, we have reported the computational studies of structural, spectroscopicand electronic behavior of a chalcone derivative:3-(2,3- dichlorophenyl)-1-(pyridine-2- yl)prop-2-en-1-one (DCPP) nonlinear optical crystal. The geometry of DCPP molecule have been optimized using density functional theory (DFT) at B3LYP level having extended basis set 6-311++G(d,p) with the help of Gaussian 09W program package. Taking this optimized geometry FTIR spectrum was simulated and analyzed quantitatively with the help of calculated potential energy distribution (PED). For finding the reactivity sites and to understand electronic and optical behavior, natural bond orbital (NBO), the electrostatic potential surface map with isodensity surface, and HOMO-LUMO analysis were also presented. Finally, the nonlinear optical behavior of this chalcone derivative was studied by calculating dipole moment (µ), polarizability (α) and hyperpolarizability (β) values. The calculated hyperpolarizability βtot of DCPP is 17.4593×10-30esu which is about 90 times greater than urea (β= 0.1947× 10-30 esu). This higher value of hyperpolarizability βtot confirms that the present molecule DCPP is a potential candidate for Nonlinear Optical applications

Effect of mindfulness on online impulse buying: Moderated mediation model of problematic internet use and emotional intelligence

Introduction: Online impulse buying behavior is an unplanned urge to buy a product or service in an online setting and it has several negative consequences for customers, such as guilt and financial distress, and e-commerce firms, such as higher returns and customer complaints. Evidently, it is important to examine the various psychological processes which may assist in a better understanding, therefore addressing the high prevalence of online impulse buying. This study builds upon self-regulation theory to explore how mindfulness influences online impulse buying, and examines problematic internet use as a mediator in the relationship between mindfulness and online impulse buying. Further, this study investigates how emotional intelligence as a moderator plays the role of a suppressant on the adverse impact of problematic Internet use which fuels online impulse buying. Method: A total of 598 individuals working with various servicebased industries responded to the questionnaire. Multiple regression and moderated mediation analysis was used using SPSS and AMOS for analyzing the data. Result: Problematic internet use mediates the relationship between mindfulness and online impulse buying behavior. Emotional intelligence negatively moderates the relationship between problematic internet use and online impulse buying behavior. Discussion: This study findings outlined the inverse relationship of mindfulness & online impulse buying, along with the mediating effect of problematic internet use between mindfulness and online impulse buying. Further, this study showed how emotional intelligence played an important role as a moderator by suppressing the adverse impact of problematic Internet use and preventing online impulse buying. The study offers implications to online marketers in regulating the unplanned purchase process—while minimizing uninhibited buying behavior that leads to regret, and the subsequent intention to return products. Further, social and theoretical implications are discussed

Efficacy of therapeutic ultrasound with soft tissue mobilization in patients of oral submucous fibrosis

Aims: To study the effect of adjuvant therapeutic ultrasound with soft tissue mobilization in the management of patients suffering from oral submucous fibrosis (OSMF). Settings and Design: This study was conducted on OSMF patients visiting the outpatient department of Oral Medicine and Radiology, ITS-CDSR, Muradnagar, Ghaziabad, in collaboration with Physiotherapy Department ITS CDSR. Materials and Methods: Thirty patients diagnosed clinically and histopathologically with OSMF were enrolled in the study. They were divided into two groups consisting 15 patients each in group A and group B.Both A and B groups were given lycopene (12mg/day) and intralesional (I/L) injection (biweekly) for 3 months. Therapeutic ultrasound with soft tissue mobilization was used only in group B. Statistical Analysis Used: An independent t-test was done for intergroup comparison for group 1 and group 2. Results: Two groups show that the difference in the treatment in both the group was highly significant at >0.01 to very highly significant at 0.001. Itshowsthat in group A, the effect is steady, and in group B, the effect is substantialwithin the first 15 days; nevertheless, the total clinical effect after 3 months is similar in both the groups. Conclusions: Therapeutic ultrasound when used as an adjuvant shows a significant improvement in the patient's condition with no reported side effects. Hence, should be incorporated in the treatment protocol for patients with OSMF