The Relationship Between Landing Error Scoring System-Real Time and Dorsiflexion Range of Motion in Recreational Athletes

Participation in physical activity is important for overall health; however, lower extremity injuries are a major risk associated with physical activity. Injuries can lead to time away from physical activity and be associated with negative health consequences. The most common injuries are traumatic injuries to the knee and ankle; which may be related to poor landing mechanics and decreased range of motion. Previous research utilizing motion analysis systems have determined people with greater dorsiflexion range of motion (DROM) demonstrated smaller ground reaction forces and greater knee and hip flexion displacement while landing; indicating a softer landing strategy. The ability to screen for landing mechanics and range of motion deficiencies is an important step in the prevention of physical activity related injuries. Therefore, the purpose of this thesis was to examine the relationship between jump landing biomechanics and DROM utilizing real-time, field-based assessments in recreational athletes. Thirty-six collegiate club soccer and basketball athletes participated in a single testing session. Jump-landing mechanics were assessed with the Landing Error Scoring System-Real Time (LESS-RT) and DROM was measured with the Weight Bearing Lunge Test (WBLT). Spearman’s rank correlations identified a weak, insignificant relationship between the WBLT summary and LESS-RT (r = 0.11, p = 0.52). Although a significant relationship was not identified, scores from individual items on the LESS-RT related to knee flexion, trunk flexion, and knee valgus were the primary contributors to poor landing mechanics and warrant further examination. Although these findings do not support previous laboratory studies, it appears the LESS-RT and WBLT may provide unique information to be considered when examining injury risk. We reject the hypothesis that there would be a relationship between LESS-RT and WBLT; however, measures of DROM and LESS-RT items in these recreational sport participants revealed areas of further examination for these lower extremity assessments

Evaluation of Balance and a Timed Walk on Ankle Brachial Pressure Index and Potential Blood Measures of Cardiovascular Health

Clinicians are focused on ways to preserve function, independence, and quality of life in the aging adult population. Heart disease is the leading cause of death in the U.S.[1]. Thus, assessing the extent of this disease is a high priority in preserving health throughout the lifespan. When determining risk of cardiovascular (CV) disease, functional assessments are recognized as a way to embed function-focused care into assessing disease risk [2]. Ankle-brachial pressure index (ABPI) is a non-invasive reliable predictor for identifying cardiovascular disease risk and mortality [3]. Thus, the purpose was to evaluate the association between functional assessments and ankle brachial pressure index in an aged population. Data was collected from the 1999-2002 National Health and Nutrition Examination Survey, which included 1696 adults (age 40-70 years). Measurements evaluated were functional assessments of a vestibular balance test and a timed 20ft walking test, and laboratory measurements of right and left leg ABPI score. Results found poor balance associated with higher odds of being in a high-risk ABPI category when looking at both left ABPI (odds ratio [OR] = 1.70; 95%CI: 0.58, 5.0) and right ABPI (OR = 2.37; 95%CI: 0.76, 7.33). Slower timed walk scores were associated with increased odds of being in the high-risk ABPI category for the left (OR = 3.21; 95%CI: 1.73, 5.98) and right (OR = 3.44; 95%CI: 2.13, 5.58). When combined, those with poor balance and slower walking speed are at higher odds for being in the high-risk ABPI category for the left (OR = 1.97; 95% 0.80, 4.85) and right (OR = 2.55; 95% 1.23, 5.79). We conclude, functional assessments are associated with a commonly used measure of CV disease risk, ABPI. Specifically, functional assessments of balance and walking speed are suggestive of risk category of ABPI, which indicates risk category for CV disease [4].https://digitalcommons.odu.edu/gradposters2020_education/1003/thumbnail.jp

Microplastic contamination of drinking water: a systematic review.

BackgroundMicroplastics (MPs) are omnipresent in the environment, including the human food chain; a likely important contributor to human exposure is drinking water.ObjectiveTo undertake a systematic review of MP contamination of drinking water and estimate quantitative exposures.MethodsThe protocol for the systematic review employed has been published in PROSPERO (PROSPERO 2019, Registration number: CRD42019145290). MEDLINE, EMBASE and Web of Science were searched from launch to the 3rd of June 2020, selecting studies that used procedural blank samples and a validated method for particle composition analysis. Studies were reviewed within a narrative analysis. A bespoke risk of bias (RoB) assessment tool was used.Results12 studies were included in the review: six of tap water (TW) and six of bottled water (BW). Meta-analysis was not appropriate due to high statistical heterogeneity (I 2 >95%). Seven studies were rated low RoB and all confirmed MP contamination of drinking water. The most common polymers identified in samples were polyethylene terephthalate (PET) and polypropylene (PP), Methodological variability was observed throughout the experimental protocols. For example, the minimum size of particles extracted and analysed, which varied from 1 to 100 μm, was seen to be critical in the data reported. The maximum reported MP contamination was 628 MPs/L for TW and 4889 MPs/L for BW, detected in European samples. Based on typical consumption data, this may be extrapolated to a maximum yearly human adult uptake of 458,000 MPs for TW and 3,569,000 MPs for BW.ConclusionsThis is the first systematic review that appraises the quality of existing evidence on MP contamination of drinking water and estimates human exposures. The precautionary principle should be adopted to address concerns on possible human health effects from consumption of MPs. Future research should aim to standardise experimental protocols to aid comparison and elevate quality

The patients' experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence.

PURPOSE: Bladder cancer (BC) is a common disease with disparate treatment options and variable outcomes. Despite the disease's high prevalence, little is known of the lived experience of affected patients. National patient experience surveys suggest that those with BC have poorer experiences than those with other common cancers. The aim of this review is to identify first-hand accounts of the lived experiences of diagnosis through to survivorship. METHOD: This is a systematic review of the qualitative evidence reporting first-hand accounts of the experiences of being diagnosed with, treated for and surviving bladder cancer. A thematic analysis and 'best-fit' framework synthesis was undertaken to classify these experiences. RESULTS: The inconsistent nature of symptoms contributes to delays in diagnosis. Post-diagnosis, many patients are not actively engaged in the treatment decision-making process and rely on their doctor's expertise. This can result in patients not adequately exploring the consequences of these decisions. Learning how to cope with a 'post-surgery body', changing sexuality and incontinence are distressing. Much less is known about the quality of life of patients receiving conservative treatments such as Bacillus Calmette-Guerin (BCG). CONCLUSIONS: The review contributes to a greater understanding of the lived experience of bladder cancer. Findings reflect a paucity of relevant literature and a need to develop more sensitive patient-reported outcome measures (PROMs) and incorporate patient-reported outcomes in BC care pathways. IMPLICATIONS FOR CANCER SURVIVORS: Collective knowledge of the patients' self-reported experience of the cancer care pathway will facilitate understanding of the outcomes following treatment

Patient and Public Involvement in Health Research in Low and Middle-Income Countries: a systematic review

Objectives: Patient and public involvement (PPI) is argued to lead to higher quality health research, which is more relatable to and helps empower the public. We synthesised the evidence to look for examples of PPI in health research in low/middle-income countries (LMICs), looking at levels of involvement and impact. Additionally, we considered the impact of who was undertaking the research on the level of involvement and reported impact. Design: Systematic review. Data sources EMBASE, Medline and PsychINFO, along with hand-searching references, grey literature, Google search and expert advice. Eligibility criteria: Any health research with evidence of patient or public involvement, with no language restrictions dated from 1978 to 1 Dec 2017. Data extraction and synthesis: Data relating to stage and level of involvement, as well as impact, were extracted by one researcher (NC), and a coding framework was developed using an inductive approach to examine the impact of PPI on research. Extracted data were then independently coded by a second lay researcher (RK) to validate the data being collected. Discrepancies were referred to a third independent reviewer (MT) for review and consensus reached. Results: Sixty-two studies met the inclusion criteria. The review revealed the most common stage for PPI was in research planning, and the most common level of involvement was collaboration. Most studies did not provide evidence of effectiveness or elaborate on the impact of PPI, and they tended to report impact from the researcher's perspective. Where impact was mentioned, this generally related to increased relevance to the community, empowerment of participants and alterations in study design. Conclusions: The literature describing approaches to and impact of PPI on LMIC health research is sparse. As PPI is essential to conducting high-quality research, it should be fully reported and evaluated at the end of the research project

Microplastic contamination of seafood intended for human consumption: a systematic review and meta-analysis

Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure.Objectives: The objectives were to conduct a systematic review and meta-analysis of the levels of MP contamination in seafood, and to subsequently estimate the annual human uptake.Methods: MEDLINE, EMBASE and Web of Science were searched from launch (1947, 1974 and 1900, respectively) up to October 2020 for all studies reporting MP content in seafood species. Mean, standard deviations (SD) and ranges of MPs found were collated. Studies were appraised systematically using a bespoke Risk of Bias (RoB) assessment tool.Results: Fifty studies were included in the systematic review and 19 in the meta-analysis. Evidence was available on four phyla; molluscs, crustaceans, fish and echinodermata. The majority of studies identified MP contamination in seafood and reported MP content below 1MPs/g (microplastics per gram), with 26% of studies rated as having high RoB, mainly due to analysis or reporting weaknesses. Molluscs collected off the coasts of Asia were the most heavily contaminated, coinciding withreported trends of MP contamination in the sea. According to the statistical summary, MP content was 0-10.5 MPs/g in molluscs, 0.1-8.6 MPs/g in crustaceans, 0-2.9 MPs/g in fish and 1MPs/g in echinodermata. Maximum annual human MP uptake was estimated to be close to 55,000 MP particles. Statistical, sample and methodological heterogeneity was high.Discussion: This is the first systematic review, to our knowledge, to assess and quantify MP contamination of seafood and human uptake from its consumption, suggesting that action must be considered in order to reduce human exposure via such consumption. Further high-quality research using standardized methods is needed to cement the scientific evidence on MP contamination and human exposures

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-analysis to identify all relevant research on MP contamination of salt intended for human consumption. Three thousand nine hundred and nineteen papers were identified, with ten fitting the inclusion criteria. A search of the databases MEDLINE, EMBASE and Web of Science, from launch date to September 2020, was conducted. MP contamination of salt varied significantly between four origins, sea salt 0–1674 MPs/kg, lake salt 8–462 MPs/kg, rock and well salt 0–204 MPs/kg. The majority of samples were found to be contaminated by MPs. Corresponding potential human exposures are estimated to be 0–6110 MPs per year (for all origins), confirming salt as a carrier of MPs. A bespoke risk of bias (RoB) assessment tool was used to appraise the quality of the studies, with studies demonstrating moderate to low RoB. These results suggest that a series of recurring issues need to be addressed in future research regarding sampling, analysis and reporting to improve confidence in research findings

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol

Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now available that slow the rate of lung function decline, trials of these treatments have failed to show improvement in symptoms or quality of life. There is an immediate unmet need for evidenced-based interventions that improve patients' symptom burden and make a difference to everyday living. This study aims to assess the feasibility of conducting a definitive randomised controlled trial of a holistic, complex breathlessness intervention in people with IPF. Methods and analysis The trial is a two-centre, randomised controlled feasibility trial of a complex breathlessness intervention compared with usual care in patients with IPF. 50 participants will be recruited from secondary care IPF clinics and randomised 1:1 to either start the intervention within 1 week of randomisation (fast-track group) or to receive usual care for 8 weeks before receiving the intervention (wait-list group). Participants will remain in the study for a total of 16 weeks. Outcome measures will be feasibility outcomes, including recruitment, retention, acceptability and fidelity of the intervention. Clinical outcomes will be measured to inform outcome selection and sample size calculation for a definitive trial. Ethics and dissemination Yorkshire and The Humber – Bradford Leeds Research Ethics Committee approved the study protocol (REC 18/YH/0147). Results of the main trial and all secondary end-points will be submitted for publication in a peer-reviewed journal

Short-Term Removal of Exercise Impairs Glycemic Control in Older Adults: A Randomized Trial

Postprandial glycemia (PPG) predicts cardiovascular disease, and short-term physical inactivity increases PPG in young, active adults. Whether this occurs in older, active adults who may be more prone to bouts of inactivity is unknown. This study determined if postprandial interstitial glucose (PPIG) was impaired in active older adults following the removal of exercise for 3 days (NOEX) compared to active young adults. In this randomized, crossover study, 11 older (69.1 ± 1.9 years) and 9 young (32.8 ± 1.8 years) habitually active (≥90 min/week of exercise) adults completed 3-days of NOEX and 3-days of normal habitual exercise (EX), separated by ≥1 week. Diet was standardized across phases. Glycemic control (3-day average) was assessed via continuous glucose monitoring during both phases. Significant main effects of age and phase were detected (p \u3c 0.05), but no interaction was found for steps/day (p \u3e 0.05) (old EX: 6283 ± 607, old NOEX: 2380 ± 382 and young EX: 8798 ± 623, young NOEX: 4075 ± 516 steps/day). Significant main effects of age (p = 0.002) and time (p \u3c 0.001) existed for 1-h PPIG, but no effect of phase or interactions was found (p \u3e 0.05). Significant main effects (p \u3c 0.05) of age (old: 114 ± 1 mg/dl, young: 106 ± 1 mg/dl), phase (NOEX: 112 ± 1 mg/dl, EX: 108 ± 1 mg/dl), and time (0 min: 100 ± 2, 30 min: 118 ± 2, 60 min: 116 ± 2, 90 min: 111 ± 2, 120 min: 108 ± 2 mg/dl) in 2-h PPIG were detected, but no interaction was found (p \u3e 0.05). However, only significant main effects of phase (NOEX: 14 ± 1 and EX:12 ± 1, p \u3e 0.05) were found for 24-h blood glucose standard deviation. Older adults appear to have impaired glycemic control compared to young adults and exercise removal impairs glycemic control in both populations. Yet, the impairment in glycemic control with exercise removal is not different between old and young adults

A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis

A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosi