Theoretical study of polar and global ozone changes using a coupled radiative-dynamical 2-D model

An existing 2-D model has recently been updated to incorporate ozone-temperature feedbacks with more comprehensive radiative transfer calculations and more detailed temperature data input. Researchers address the following issues: (1) given the observed temperature changes for the past eight years, quantitatively how much ozone change can be produced by the dynamical effect of the temperature change over the Arctic and Antarctic; (2) how much of the reported change in globally averaged ozone can be accounted for by temperature changes; (3) the role of the diabatic circulation changes in the lower stratosphere in determining the timing of the polar spring maximum and minimum; and (4) the role of the seasonal change in the diabatic circulation in causing the fall minimum over the Arctic and Antarctic

Observation of Vortex Pinning in Bose-Einstein Condensates

We report the observation of vortex pinning in rotating gaseous Bose-Einstein condensates (BEC). The vortices are pinned to columnar pinning sites created by a co-rotating optical lattice superimposed on the rotating BEC. We study the effects of two different types of optical lattice, triangular and square. With both geometries we see an orientation locking between the vortex and the optical lattices. At sufficient intensity the square optical lattice induces a structural cross-over in the vortex lattice.Comment: 4 pages, 6 figures. Replaced by final version to appear in Phys. Rev. Let

Theory of minimum effort control

Optimum control theory formulations for solving problems in optimum guidance for interplanetary manned space flight mission

Experimental studies of equilibrium vortex properties in a Bose-condensed gas

We characterize several equilibrium vortex effects in a rotating Bose-Einstein condensate. Specifically we attempt precision measurements of vortex lattice spacing and the vortex core size over a range of condensate densities and rotation rates. These measurements are supplemented by numerical simulations, and both experimental and numerical data are compared to theory predictions of Sheehy and Radzihovsky [17] (cond-mat/0402637) and Baym and Pethick [25] (cond-mat/0308325). Finally, we study the effect of the centrifugal weakening of the trapping spring constants on the critical temperature for quantum degeneracy and the effects of finite temperature on vortex contrast.Comment: Fixed minor notational inconsistencies in figures. 12 pages, 8 figure

The potential for liquid biopsies in the precision medical treatment of breast cancer.

Currently the clinical management of breast cancer relies on relatively few prognostic/predictive clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary tumor biology. Circulating biomarkers, such as circulating tumor DNA (ctDNA) or circulating tumor cells (CTCs) may enhance our treatment options by focusing on the very cells that are the direct precursors of distant metastatic disease, and probably inherently different than the primary tumor's biology. To shift the current clinical paradigm, assessing tumor biology in real time by molecularly profiling CTCs or ctDNA may serve to discover therapeutic targets, detect minimal residual disease and predict response to treatment. This review serves to elucidate the detection, characterization, and clinical application of CTCs and ctDNA with the goal of precision treatment of breast cancer

SLIM : Scalable Linkage of Mobility Data

We present a scalable solution to link entities across mobility datasets using their spatio-temporal information. This is a fundamental problem in many applications such as linking user identities for security, understanding privacy limitations of location based services, or producing a unified dataset from multiple sources for urban planning. Such integrated datasets are also essential for service providers to optimise their services and improve business intelligence. In this paper, we first propose a mobility based representation and similarity computation for entities. An efficient matching process is then developed to identify the final linked pairs, with an automated mechanism to decide when to stop the linkage. We scale the process with a locality-sensitive hashing (LSH) based approach that significantly reduces candidate pairs for matching. To realize the effectiveness and efficiency of our techniques in practice, we introduce an algorithm called SLIM. In the experimental evaluation, SLIM outperforms the two existing state-of-the-art approaches in terms of precision and recall. Moreover, the LSH-based approach brings two to four orders of magnitude speedup

Observation of the Presuperfluid Regime in a Two-Dimensional Bose Gas

In complementary images of coordinate-space and momentum-space density in a trapped 2D Bose gas, we observe the emergence of pre-superfluid behavior. As phase-space density $\rho$ increases toward degenerate values, we observe a gradual divergence of the compressibility $\kappa$ from the value predicted by a bare-atom model, $\kappa_{ba}$. $\kappa/\kappa_{ba}$ grows to 1.7 before $\rho$ reaches the value for which we observe the sudden emergence of a spike at $p=0$ in momentum space. Momentum-space images are acquired by means of a 2D focusing technique. Our data represent the first observation of non-meanfield physics in the pre-superfluid but degenerate 2D Bose gas.Comment: Replace with the version appeared in PR