Using opium as a public revenue source - not as easy as it looks: the British Hong Kong experience

This article summarizes the reasons the colonial government in Hong Kong decided to make the internal retail trade in opium a major source of revenue. It also: explains the operation and enforcement of this revenue system; evaluates the fiscal performance of this revenue system; and considers its contemporary and lasting impact on the development of Hong Kong. The primary research focus is on the first 50 years of the operation of the system for it took almost this long for the revenue raising performance of the system finally to match the original, fund-raising expectations.postprin

The Role of Phase Space in Complex Fragment Emission from Low to Intermediate Energies

The experimental emission probabilities of complex fragments by low energy compound nuclei and their dependence upon energy and atomic number are compared to the transition state rates. Intermediate-mass-fragment multiplicity distributions for a variety of reactions at intermediate energies are shown to be binomial and thus reducible at all measured transverse energies. From these distributions a single binary event probability can be extracted which has a thermal dependence. A strong thermal signature is also found in the charge distributions. The n-fold charge distributions are reducible to the 1-fold charge distributions through a simple scaling dictated by fold number and charge conservation.Comment: 15 pages, TeX type, psfig, also available at http://csa5.lbl.gov/moretto/ps/brazil.ps, to appear in Proceedings of the 1st International Conference on Nuclear Dynamics at Long and Short Distances, April 8-12, 1996, Angra dos Reis, Brazi

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease.

Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD. Using the IL-10 gene-deficient mouse model of IBD and wild-type mice, urine at age 4, 6, 8, 12, 16, and 20 weeks was collected and analyzed by nuclear magnetic resonance (NMR) spectroscopy. Multivariate data analysis was employed to assess differences in metabolomic profiles that occurred as a consequence of IBD development and severity (at week 20). These changes were contrasted to those that occurred as a consequence of gender. Our results demonstrate that both IL-10 gene-deficient and wild-type mice exhibit gender-related changes in urinary metabolomic profile over time. Some male-female separating metabolites are common to both IL-10 gene-deficient and control wild-type mice and, therefore, appear to be related predominantly to gender maturation. In addition, we were able to identify gender-separating metabolites that are unique for IL-10 gene-deficient and wild-type mice and, therefore, may be indicative of a gender-specific involvement in the development and severity of the intestinal inflammation. The comparison of the gender-separating metabolomic profile from IL-10 gene-deficient mice and wild-type mice during the development of IBD allowed us to identify changes in profile patterns that appear to be imperative in the development of intestinal inflammation, but yet central to gender-related differences in IBD development. The knowledge of metabolomic profile differences by gender and by disease severity has potential clinical implications in the design of both biomarkers of disease as well as the development of optimal therapies

Lack of CD8+ T-cell co-localization with Kaposi’s sarcoma- associated herpesvirus infected cells in Kaposi’s sarcoma tumors

Despite the close association between Kaposi’s sarcoma (KS) and immune dysfunction, it remains unclear whether tumor infiltrating immune cells (TIIC), by their absence, presence, or dysfunction, are mechanistically correlated with KS pathogenesis. Therefore, their potential capacity to serve as prognostic biomarkers of KS disease progression or control is unclear. Because epidemic-KS (EpKS) occurs with HIV-1 co-infection, it is particularly important to compare TIIC between EpKS and HIV-negative African endemic-KS (EnKS) to dissect the roles of HIV-1 and Kaposi Sarcoma-associated herpesvirus (KSHV) in KS pathogenesis. This cross-sectional study of 13 advanced KS (4 EnKS, 9 EpKS) patients and 3 healthy controls utilized single-color immunohistochemistry and dual-color immunofluorescence assays to characterize and quantify KSHV infected cells in relation to various TIIC in KS biopsies. Analysis of variance (ANOVA) and Mann-Whitney tests were used to assess differences between groups where P-values \u3c 0.05 were considered significant. The abundance of KSHV infected cells was heterogeneous in KS biopsies. Despite the presence of T-cell chemoattractant chemokine CxCL-9 in biopsies, CD8+ T-cells were sparsely distributed in regions with evident KSHV infected cells but were readily detectable in regions devoid of KSHV infected cells (P \u3c 0.0001). CD68+ (M1) macrophages were evenly and diffusely distributed in KS biopsies, whereas, the majority of CD163+ (M2) macrophages were localized in regions devoid of KSHV infected cells (P \u3c 0.0001). Overall, the poor immune cell infiltration or co-localization in KS biopsies independent of HIV-1 co-infection suggests a fundamental tumor immune evasion mechanism that warrants further investigation

SDN-based Virtual Machine Management for Cloud Data Centers

Software-Defined Networking (SDN) is an emerging paradigm to logically centralize the network control plane and automate the configuration of individual network elements. At the same time, in Cloud Data Centers (DCs), even though network and server resources converge over the same infrastructure and typically under a single administrative entity, disjoint control mechanisms are used for their respective management. In this paper, we propose a unified server-network control mechanism for converged ICT environments. We present a SDN-based orchestration framework for live Virtual Machine (VM) management where server hypervisors exploit temporal network information to migrate VMs and minimize the network-wide communication cost of the resulting traffic dynamics. A prototype implementation is presented and Mininet is used to evaluate the impact of diverse orchestration algorithms

Economical (k,m)-threshold controlled quantum teleportation

We study a (k,m)-threshold controlling scheme for controlled quantum teleportation. A standard polynomial coding over GF(p) with prime p > m-1 needs to distribute a d-dimensional qudit with d >= p to each controller for this purpose. We propose a scheme using m qubits (two-dimensional qudits) for the controllers' portion, following a discussion on the benefit of a quantum control in comparison to a classical control of a quantum teleportation.Comment: 11 pages, 2 figures, v2: minor revision, discussions improved, an equation corrected in procedure (A) of section 4.3, v3: major revision, protocols extended, citations added, v4: minor grammatical revision, v5: minor revision, discussions extende

SDN-based Virtual Machine Management for Cloud Data Centers

Software-Defined Networking (SDN) is an emerging paradigm to logically centralize the network control plane and automate the configuration of individual network elements. At the same time, in Cloud Data Centers (DCs), although network and server resources are collocated and managed by a single administrative entity, disjoint control mechanisms are used for their respective management. In this article, we propose a unified server-network resource management for such converged Information and Communication Technology (ICT) environments. We present a SDN-based orchestration framework for live Virtual Machine (VM) management that exploits temporal network information to migrate VMs and minimize the network-wide communication cost of the resulting traffic dynamics. A prototype implementation is presented, and a Cloud DC testbed is used to evaluate the impact of diverse orchestration algorithms. Our live VM management has been shown to reduce the network-wide communication cost, especially for the high-cost and congestionprone core and aggregation layers of the DC. Our results show an increase in network-wide throughput by over 6 times, as well as over 70% communication cost reduction by migrating less than 50% of the VMs

Software fault-tolerance by design diversity DEDIX: A tool for experiments

The use of multiple versions of a computer program, independently designed from a common specification, to reduce the effects of an error is discussed. If these versions are designed by independent programming teams, it is expected that a fault in one version will not have the same behavior as any fault in the other versions. Since the errors in the output of the versions are different and uncorrelated, it is possible to run the versions concurrently, cross-check their results at prespecified points, and mask errors. A DEsign DIversity eXperiments (DEDIX) testbed was implemented to study the influence of common mode errors which can result in a failure of the entire system. The layered design of DEDIX and its decision algorithm are described

Resilient Reducibility in Nuclear Multifragmentation

The resilience to averaging over an initial energy distribution of reducibility and thermal scaling observed in nuclear multifragmentation is studied. Poissonian reducibility and the associated thermal scaling of the mean are shown to be robust. Binomial reducibility and thermal scaling of the elementary probability are robust under a broad range of conditions. The experimental data do not show any indication of deviation due to averaging.Comment: 5 pages, 6 figures, submitted to Physical Review