Focusing Attention on the Health Aspects of Foods Changes Value Signals in vmPFC and Improves Dietary Choice

Attention is thought to play a key role in the computation of stimulus values at the time of choice, which suggests that attention manipulations could be used to improve decision-making in domains where self-control lapses are pervasive. We used an fMRI food choice task with non-dieting human subjects to investigate whether exogenous cues that direct attention to the healthiness of foods could improve dietary choices. Behaviorally, we found that subjects made healthier choices in the presence of health cues. In parallel, stimulus value signals in ventromedial prefrontal cortex were more responsive to the healthiness of foods in the presence of health cues, and this effect was modulated by activity in regions of dorsolateral prefrontal cortex. These findings suggest that the neural mechanisms used in successful self-control can be activated by exogenous attention cues, and provide insights into the processes through which behavioral therapies and public policies could facilitate self-control

Recent Results in Bottomonium

Great strides have been made in the understanding of bound states of a bottom quark $b$ and its antiquark $\bar b$ since the discovery of the first $\Upsilon$ resonances in 1977. These {\it bottomonium} bound states have a rich spectrum whose masses and transition amplitudes shed valuable light on the strong interactions. The present article reviews some recent developments in bottomonium physics. These include the discovery of the spin-singlet states $\eta_b$ and $h_b$, the first D-wave states, one or more candidates for spin-triplet $\chi_b(3P)$ excitations, and above-threshold states with strong transitions to states below threshold. Information on transitions, production, and signatures of new physics is also presented.Comment: 47 pages, 2 figures, to be submitted to Annual Review of Nuclear and Particle Scienc

Augmentative and Alternative Communication in the Intensive Care Unit

Current research is lacking on the frequency of augmentative and alternative communication (AAC) system use in intensive care units (ICU) and clinical decision making patterns. AAC is use of any alternative method of communication when oral communication cannot be achieved (ASHA, 2013). Patients in the ICU may become nonverbal for many reasons including tracheostomy, mechanical ventilation (McKinley, Pooke, & White, 2010) and intubation (Radtke, Bauman, Garrett, & Happ, 2011). Being nonverbal in the ICU may lead to poorer health outcomes (Patak, Wilson-Stronks, & Costello, 2009). AAC systems may improve outcomes by allowing patients to communicate more clearly with family, friends, and hospital staff. ICU patients communicate with nurses more than any other healthcare professional (Happ, Tuite, Dobbin, DiVirgilio-Thomas, & Kitutu, 2004). AAC systems are crucial for patient-nurse communication. Speech-language pathologists (SLPs) evaluate for and provide AAC systems to individuals across the lifespan and setting, including those in ICU. Forty SLPs who worked in a hospital with an ICU and 8 RNs who worked in the ICU responded to an electronic survey. Half of the SLPs indicated some form of AAC was being used in the ICU. The majority of RNs (n=5) responded that AAC was seldom used in the ICU. Lack of equipment/resources, time constrains, and feasibility were among the most selected reasons why AAC was not being provided per SLPs. Overall, results from the research suggested that AAC is not standard practice within the ICU

History, Violence, and Legitimacy in Uganda: An Anthropological Analysis of Post-Colonial Politics and ICC Intervention

In recent debates between social scientists and human rights and legal scholars, many anthropologists have argued that the successes or failures of transitional justice mechanisms to contribute to peace depend on a wide range of contextually situated historical, political, socio-economic, and cultural factors (see Hinton 2010). Human rights organizations often disregard or sideline such contextual specifics and favor a narrow definition of justice in terms of the unwavering punitive orthodoxy of international courts as the primary solution to conflict. Looking through an anthropological lens in this paper, I focus on the history of politics in post-colonial Uganda in order to render clearer the cycle of violence that emerged as a prominent feature of the political landscape of the region. Against this contextualized backdrop, I investigate the case of conflict between the Ugandan state and the Lord’s Resistance Army, and problematize the role of one international human rights organization, the International Criminal Court. I argue that by continuing its intervention in Uganda’s justice matters, the ICC is inadvertently granting the same kind of amnesty to past atrocities that it so condemns for present ones, and in doing so, grants international legitimacy to the current state while de-legitimizing non-state local forms of justice. Although ethnographic “field notes” are not included in the following pages, this essay represents one anthropologist’s analytical engagement with issues of justice in Uganda

Biochemical, kinetic, and spectroscopic characterization of Ruegeria pomeroyi DddW - A mononuclear iron-dependent DMSP lyase

The osmolyte dimethylsulfoniopropionate (DMSP) is a key nutrient in marine environments and its catabolism by bacteria through enzymes known as DMSP lyases generates dimethylsulfide (DMS), a gas of importance in climate regulation, the sulfur cycle, and signaling to higher organisms. Despite the environmental significance of DMSP lyases, little is known about how they function at the mechanistic level. In this study we biochemically characterize DddW, a DMSP lyase from the model roseobacter Ruegeria pomeroyi DSS-3. DddW is a 16.9 kDa enzyme that contains a C-terminal cupin domain and liberates acrylate, a proton, and DMS from the DMSP substrate. Our studies show that as-purified DddW is a metalloenzyme, like the DddQ and DddP DMSP lyases, but contains an iron cofactor. The metal cofactor is essential for DddW DMSP lyase activity since addition of the metal chelator EDTA abolishes its enzymatic activity, as do substitution mutations of key metal-binding residues in the cupin motif (His81, His83, Glu87, and His121). Measurements of metal binding affinity and catalytic activity indicate that Fe(II) is most likely the preferred catalytic metal ion with a nanomolar binding affinity. Stoichiometry studies suggest DddW requires one Fe(II) per monomer. Electronic absorption and electron paramagnetic resonance (EPR) studies show an interaction between NO and Fe(II)-DddW, with NO binding to the EPR silent Fe(II) site giving rise to an EPR active species (g = 4.29, 3.95, 2.00). The change in the rhombicity of the EPR signal is observed in the presence of DMSP, indicating that substrate binds to the iron site without displacing bound NO. This work provides insight into the mechanism of DMSP cleavage catalyzed by DddW

Spatial patterns of tree yield explained by endogenous forces through a correspondence between the Ising model and ecology.

Spatial patterning of periodic dynamics is a dramatic and ubiquitous ecological phenomenon arising in systems ranging from diseases to plants to mammals. The degree to which spatial correlations in cyclic dynamics are the result of endogenous factors related to local dynamics vs. exogenous forcing has been one of the central questions in ecology for nearly a century. With the goal of obtaining a robust explanation for correlations over space and time in dynamics that would apply to many systems, we base our analysis on the Ising model of statistical physics, which provides a fundamental mechanism of spatial patterning. We show, using 5 y of data on over 6,500 trees in a pistachio orchard, that annual nut production, in different years, exhibits both large-scale synchrony and self-similar, power-law decaying correlations consistent with the Ising model near criticality. Our approach demonstrates the possibility that short-range interactions can lead to long-range correlations over space and time of cyclic dynamics even in the presence of large environmental variability. We propose that root grafting could be the common mechanism leading to positive short-range interactions that explains the ubiquity of masting, correlated seed production over space through time, by trees