"AI enhances our performance, I have no doubt this one will do the same": The Placebo effect is robust to negative descriptions of AI

Heightened AI expectations facilitate performance in human-AI interactions through placebo effects. While lowering expectations to control for placebo effects is advisable, overly negative expectations could induce nocebo effects. In a letter discrimination task, we informed participants that an AI would either increase or decrease their performance by adapting the interface, but in reality, no AI was present in any condition. A Bayesian analysis showed that participants had high expectations and performed descriptively better irrespective of the AI description when a sham-AI was present. Using cognitive modeling, we could trace this advantage back to participants gathering more information. A replication study verified that negative AI descriptions do not alter expectations, suggesting that performance expectations with AI are biased and robust to negative verbal descriptions. We discuss the impact of user expectations on AI interactions and evaluation and provide a behavioral placebo marker for human-AI interactio

The Impact of Screen Time and Mobile Dependency on Cognition, Socialization and Behaviour Among Early Childhood Students During the Covid Pandemic- Perception of the Parents

Digital technology systems are adopted rapidly throughout the globe for the virtual learning process especially with the outbreak of the Covid-19 pandemic. Digital screen-based gadgets are integrated to provide a seamless interactive medium of learning even before the initiation of formal education. Studies on the technology use of younger children are critical as uncontrolled gadget use affects their developmental stages yet these studies are still in the infancy stage. This study analyses the psychoeducational impact of extended use of digital gadgets and mobile dependency on early childhood manifested through their cognition, socialization and behaviour. This descriptive study is based on the random responses of 511 parents about their young children of 3-6 years distributed at five civil districts of Kerala State. From the analysis, it is found that the extended use of digital gadgets influenced young children’s mobile dependency, socialization process, cognition and behaviour patterns. The young children exhibited alienation tendencies and behavioural deviations which are correlated to their screen time. Both male and female reported similar results.  Significant differences were observed with respect to the age of the children and their parental characteristics. Their mobile dependency mediated their extended digital Screen Time to the Behaviour. Significant relation was predicted by extended Screen Time on Behaviour of the students with a partial sequential path through mobile Dependency, Cognition and Socialization. The study shed light on the urgency of parental care and implementation of a balanced gadget usage system to reduce the detrimental impacts of psychoeducational factors

Breathing new life into tissue engineering: exploring cutting-edge vascularization strategies for skin substitutes

Tissue-engineered skin substitutes (TESS) emerged as a new therapeutic option to improve skin transplantation. However, establishing an adequate and rapid vascularization in TESS is a critical factor for their clinical application and successful engraftment in patients. Therefore, several methods have been applied to improve the vascularization of skin substitutes including (i) modifying the structural and physicochemical properties of dermal scaffolds; (ii) activating biological scaffolds with growth factor-releasing systems or gene vectors; and (iii) developing prevascularized skin substitutes by loading scaffolds with capillary-forming cells. This review provides a detailed overview of the most recent and important developments in the vascularization strategies for skin substitutes. On the one hand, we present cell-based approaches using stem cells, microvascular fragments, adipose tissue derived stromal vascular fraction, endothelial cells derived from blood and skin as well as other pro-angiogenic stimulation methods. On the other hand, we discuss how distinct 3D bioprinting techniques and microfluidics, miRNA manipulation, cell sheet engineering and photosynthetic scaffolds like GelMA, can enhance skin vascularization for clinical applications. Finally, we summarize and discuss the challenges and prospects of the currently available vascularization techniques that may serve as a steppingstone to a mainstream application of skin tissue engineering

Effects of vitamin D deficiency on neurobehavioural outcomes in children: a systematic review

Introduction: Vitamin D plays an important role in brain development in experimental studies; however, the effect of vitamin D deficiency on child development remains inadequately characterized. We aimed to estimate the effects of vitamin D deficiency on neurobehavioural outcomes in children up to 18 years of age. Methods: We searched PubMed, EMBASE, PsycINFO, Scopus, Cochrane Library, Web of Science and Open Grey for published studies up to 10th January 2020. We included all studies that assessed the effects of maternal or child vitamin D status or vitamin D supplementation on neurobehavioural outcomes in children. Study findings were synthesized qualitatively as the high level of heterogeneity in study populations and methodologies precluded a quantitative meta-analysis. Results: Our search identified 5,633 studies, of which 31 studies with 31,375 participants from 18 countries were included in the systematic review. Of the studies identified, one was a randomised controlled trial (RCT) of vitamin D supplementation in children, while 30 were observational. The RCT (n=55) reported a beneficial effect of supplementation with lower doses compared to higher doses of vitamin D on motor development. Twelve mother-child studies (n=17,136) and five studies in children (n=1,091) reported an association between low maternal or child 25-hydroxyvitamin D levels and impaired neurobehavioural outcomes in children, while 15 mother-child studies (n=20,778) and eight studies in children (n=7,496) reported no association. Conclusions: Although animal studies point to an effect of vitamin D deficiency on brain development, there are few studies on the effects of vitamin D deficiency on neurobehavioural outcomes in children and their findings are inconsistent. There is a need for well-conducted, adequately powered studies to further determine these effects in children

Diagnosing 0.1–10 au Scale Morphology of the FU Ori Disk Using ALMA and VLTI/GRAVITY

We report new Atacama Large Millimeter/submillimeter Array Band 3 (86–100 GHz; ~80 mas angular resolution) and Band 4 (146–160 GHz; ~50 mas angular resolution) observations of the dust continuum emission toward the archetypal and ongoing accretion burst young stellar object FU Ori, which simultaneously covered its companion, FU Ori S. In addition, we present near-infrared (2–2.45 μm) observations of FU Ori taken with the General Relativity Analysis via VLT InTerferometrY (GRAVITY; ~1 mas angular resolution) instrument on the Very Large Telescope Interferometer (VLTI). We find that the emission in both FU Ori and FU Ori S at (sub)millimeter and near-infrared bands is dominated by structures inward of ~10 au radii. We detected closure phases close to zero from FU Ori with VLTI/GRAVITY, which indicate the source is approximately centrally symmetric and therefore is likely viewed nearly face-on. Our simple model to fit the GRAVITY data shows that the inner 0.4 au radii of the FU Ori disk has a triangular spectral shape at 2–2.45 μm, which is consistent with the H2O and CO absorption features in a 10−4 M ⊙ yr−1, viscously heated accretion disk. At larger (~0.4–10 au) radii, our analysis shows that viscous heating may also explain the observed (sub)millimeter and centimeter spectral energy distribution when we assume a constant, ~10−4 M ⊙ yr−1 mass inflow rate in this region. This explains how the inner 0.4 au disk is replenished with mass at a modest rate, such that it neither depletes nor accumulates significant masses over its short dynamic timescale. Finally, we tentatively detect evidence of vertical dust settling in the inner 10 au of the FU Ori disk, but confirmation requires more complete spectral sampling in the centimeter bands

Burosumab therapy in children with x-linked hypophosphatemia

BACKGROUND X-linked hypophosphatemia is characterized by increased secretion of fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently rickets, osteomalacia, and skeletal deformities. We investigated burosumab, a monoclonal antibody that targets FGF-23, in patients with X-linked hypophosphatemia. METHODS In an open-label, phase 2 trial, we randomly assigned 52 children with X-linked hypophosphatemia, in a 1:1 ratio, to receive subcutaneous burosumab either every 2 weeks or every 4 weeks; the dose was adjusted to achieve a serum phosphorus level at the low end of the normal range. The primary end point was the change from baseline to weeks 40 and 64 in the Thacher rickets severity total score (ranging from 0 to 10, with higher scores indicating greater disease severity). In addition, the Radiographic Global Impression of Change was used to evaluate rachitic changes from baseline to week 40 and to week 64. Additional end points were changes in pharmacodynamic markers, linear growth, physical ability, and patient-reported outcomes and the incidence of adverse events. RESULTS The mean Thacher rickets severity total score decreased from 1.9 at baseline to 0.8 at week 40 with every-2-week dosing and from 1.7 at baseline to 1.1 at week 40 with every-4-week dosing (P<0.001 for both comparisons); these improvements persisted at week 64. The mean serum phosphorus level increased after the first dose in both groups, and more than half the patients in both groups had levels within the normal range (3.2 to 6.1 mg per deciliter [1.0 to 2.0 mmol per liter]) by week 6. Stable serum phosphorus levels were maintained through week 64 with every-2-week dosing. Renal tubular phosphate reabsorption increased from baseline in both groups, with an overall mean increase of 0.98 mg per deciliter (0.32 mmol per liter). The mean dose of burosumab at week 40 was 0.98 mg per kilogram of body weight with every-2-week dosing and 1.50 mg per kilogram with every-4-week dosing. Across both groups, the mean serum alkaline phosphatase level decreased from 459 U per liter at baseline to 369 U per liter at week 64. The mean standing-height z score increased in both groups, with greater improvement seen at all time points with every-2-week dosing (an increase from baseline of 0.19 at week 64) than with every-4-week dosing (an increase from baseline of 0.12 at week 64). Physical ability improved and pain decreased. Nearly all the adverse events were mild or moderate in severity. CONCLUSIONS In children with X-linked hypophosphatemia, treatment with burosumab improved renal tubular phosphate reabsorption, serum phosphorus levels, linear growth, and physical function and reduced pain and the severity of rickets

An Analysis of the Environments of FU Orionis Objects with Herschel

We present Herschel-HIFI, SPIRE, and PACS 50-670 {\mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936-2010, from the "FOOSH" (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer-IRS and the Caltech Submillimeter Observatory. In their system properties (Lbol, Tbol, line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of 13CO (J_up of 5 to 8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 - 22 and evidence for H2O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for "cool" CO components range from 20-81 K, for ~ 10^50 total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.Comment: 31 pages, 15 figures; accepted to Ap

Assessing Margin-wide Rupture Behavior along hte Cascadia Megathrust using 3-D Dynamic Rupture Simulations

This work is a non-peer reviewed preprint submitted to EarthArXiv. It is currently under review at Journal of Geophysical Research: Solid Earth.From California to British Columbia, the Pacific Northwest coast bears an omnipresent earthquake and tsunami hazard from the Cascadia subduction zone. Multiple lines of evidence suggests that magnitude eight and greater megathrust earthquakes have occurred - the most recent being 321 years ago (i.e., 1700 A.D.). Outstanding questions for the next great megathrust event include where it will initiate, what conditions are favorable for rupture to span the convergent margin, and how much slip may be expected. We develop the first 3-D fully dynamic rupture simulations that are driven by fault stress, strength and friction to address these questions. The initial dynamic stress drop distribution in our simulations is constrained by geodetic coupling models, with segment locations taken from paleoseismic analyses. We document the sensitivity of nucleation location and stress drop to the final seismic moment and coseismic subsidence amplitudes. We find that the final earthquake size strongly depends on the amount of slip deficit in the central Cascadia region, which is inferred to be creeping interseismically, for a given initiation location in southern or northern Cascadia. Several simulations are also presented here that can closely approximate recorded coastal subsidence from the 1700 A.D. event without invoking localized high-stress asperities along the down-dip locked region of the megathrust. These results can be used to inform earthquake and tsunami hazards for not only Cascadia, but other subduction zones that have limited seismic observations but a wealth of geodetic inference.http://deepblue.lib.umich.edu/bitstream/2027.42/167720/1/Ramos_et_al_JGR_submission_eartharxiv.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167720/2/Ramos_et_al_Supplemental_Info_eartharxiv.pdfDescription of Ramos_et_al_JGR_submission_eartharxiv.pdf : Main articleDescription of Ramos_et_al_Supplemental_Info_eartharxiv.pdf : Supplemental infoSEL

Implementation of palliative care consult Service in Hungary

__Background:__ The Palliative Care Consult Service (PCCS) programme was among the first initiations in Hungary to provide palliative care for patients admitted to hospital. The PCCS team provides palliative care for mainly cancer patients and their family members and manages the patient pathway after being discharged from the hospital. The service started in 2014 with 300-400 patient visits per year. The aim of this study is to give a comprehensive overview of the PCCS programme guided by a conceptual framework designed by SELFIE ("Sustainable intEgrated chronic care modeLs for multi-morbidity: delivery, FInancing, and performancE"), a Horizon2020 funded EU project and to identify the facilitators and barriers to its wider implementation. __Methods:__ PCCS has been selected by the SELFIE consortium for in-depth evaluation as one of the Hungarian integrated care models for persons with multi-morbidity. The qualitative analysis of the PCCS programme was based on available documents of the care provider and interviews with different stakeholders related to the programme. __Results:__ The integrated, multidisciplinary and patient-centred approach was well-received among the patients, family members and clinical departments, as verified by the increasing number of requests for consultations. As a result of the patient pathway management across providers (e.g. from inpatient care to homecare) a higher level of coordination could be achieved in the continuity of care for seriously-ill patients. The regulatory framework has only partially been established, policies to integrate care across organizations and sectors and adequate financial mechanism to support the enhancement and sustainability of the PCCS are still missing. __Conclusions:__ The service integration of palliative car