Neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy

Background: The aim of the study was to find out the neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy at 6 months of age and to predict early markers of abnormal neurological outcome in those babies.Methods: 50 babies admitted with hypoxic ischemic encephalopathy were enrolled in this prospective study and followed up at 3 and 6 months of age at Mahatma Gandhi Memorial Government Hospital, Trichy. The neurological outcome of the babies was assessed by CDC grading of motor milestones, Trivandrum development screening chart, Amiel Tison angles head circumference and weight measured. USG cranium was done for all the babies and MRI brain was done in babies with abnormal neuro sonogram and abnormal outcome. Vision and hearing were tested clinically.Results: The incidence of abnormal neurological outcome was 14%. The early markers predicting abnormal neurological sequele are identified.Conclusions: Early identification of abnormal neuro behaviour helps in starting early intervention to improve the long term outcome

METHOD AND SYSTEM FOR BI CUBE REFRESH AUTOMATION

The present disclosure relates to a system for BI cube refresh automation. In the present disclosure, initially the status of the I-server 107 is determined. Once the I-server is active, the cube refresh automation system 103 may back-up the old workflow logs and deletes the old workflow logs from one or more data cubes 101. Further, the cube refresh automation system may split the insertion of new workflow logs into clustered server and then merges the insertion results from the clustered servers. The merger insertion results are further monitored. Upon successful insertion, the insertion trigger is deleted. When the insertion is unsuccessful, the cube refresh automation system provides a successive trigger for insertion. Further, upon the successful insertion the trigger for the insertion is deleted. Finally, the cube refresh automation system 103 provides the information inserted in one more data cubes and cube health status to the user through notification

Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime

The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine. Keywords: N-Benzyl piperidin 4-one oxime, meristamatic cells, mitotic index

Investigation of cutting force in end milling of Al/n-Tic/MoS2 sintered nano composite

In industries, metal matrix nano-composites have implied its position by the mechanical properties. But, studies have given importance to micro/macrosize particles. The main aim of the research analysis is to understand the influence of machining parameters for the cutting force (Fc) and surface roughness (Ra) in end milling of hybrid nanocomposites Al + 10 % n-Tic + 7,5 % MoS2. Powder metallurgy process is adopted to prepare nano-composite samples. Microstructural analysis of nano-composite material done by Field Emission Scanning Electron Microscope (FESEM) confirms the uniform distribution of the reinforced particle. Experimentation was conducted by Central Composite Design (CCD), and the evaluation of surface roughness and cutting force was carried out using Response Surface Methodology (RSM) and Genetic Algorithm (GA)

Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.

Purpose: The retinoblastoma tumor suppressor (RB), a key regulator of cell-cycle progression and proliferation, is functionally suppressed in up to 50% of non-small cell lung cancer (NSCLC). RB function is exquisitely controlled by a series of proteins, including the CyclinD-CDK4/6 complex. In this study, we interrogated the capacity of a CDK4/6 inhibitor, palbociclib, to activate RB function. Experimental Design and Results: We employed multiple isogenic RB-proficient and -deficient NSCLC lines to interrogate the cytostatic and cytotoxic capacity of CDK 4/6 inhibition in vitro and in vivo We demonstrate that while short-term exposure to palbociclib induces cellular senescence, prolonged exposure results in inhibition of tumor growth. Mechanistically, CDK 4/6 inhibition induces a proapoptotic transcriptional program through suppression of IAPs FOXM1 and Survivin, while simultaneously augmenting expression of SMAC and caspase-3 in an RB-dependent manner. Conclusions: This study uncovers a novel function of RB activation to induce cellular apoptosis through therapeutic administration of a palbociclib and provides a rationale for the clinical evaluation of CDK 4/6 inhibitors in the treatment of patients with NSCLC

AUTO-CDD: automatic cleaning dirty data using machine learning techniques

Cleaning the dirty data has become very critical significance for many years, especially in medical sectors. This is the reason behind widening research in this sector. To initiate the research, a comparison between currently used functions of handling missing values and Auto-CDD is presented. The developed system will guarantee to overcome processing unwanted outcomes in data Analytical process; second, it will improve overall data processing. Our motivation is to create an intelligent tool that will automatically predict the missing data. Starting with feature selection using Random Forest Gini Index values. Then by using three Machine Learning Paradigm trained model was developed and evaluated by two datasets from UCI (i.e. Diabetics and Student Performance). Evaluated outcomes of accuracy proved Random Forest Classifier and Logistic Regression gives constant accuracy at around 90%. Finally, it concludes that this process will help to get clean data for further analytical process

High performance thin-layer chromatography and in vitro cytotoxic studies on ethanol extract of Matricaria chamomilla L (Asteraceae) flowers

Purpose: To develop a high performance thin-layer chromatography (HPTLC procedure for quantitation of apigenin in ethanol extract of Matricaria chamomilla (Babunaj) flowers, and to evaluate the extract for in vitro cytotoxic effect on MCF-7 cell lines. Methods: Quantification of apigenin was carried out using a CAMAG TLC system. A combination of toluene, ethyl acetate and formic acid (4.5:3.5:0.2 v/v/v) was used as mobile phase, with densitometry detection at 336 nm. The HPTLC procedure was subjected to validation as per ICH guidelines. The cytotoxicity of the extract was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Results: A sharp apigenin band at Rf of 0.51 was obtained, and the content of apigenin in the extract was 0.062 % w/w. The detection limit (LOD) and quantification limit (LOQ) were 0.19 and 0.57 ng/band, respectively. MTT assay results indicate that M. chamomilla was cytotoxic to Michigan Cancer Foundation-7 (MCF-7) cells, with half-maximal concentration (IC50) of 74 µg/mL. Conclusion: The developed HPTLC method is linear, precise, accurate and specific for the determination of apigenin. M. chamomilla exerts cytotoxic effect on MCF-7 cell line via induction of apoptosis