Alla base di uno stereotipo: il successo dei mungitori punjabi in Emilia-Romagna

Starting from the ‘90s, Emilia-Romagna’s milking niche has experienced the progressive involvement of workers coming from the Indian state of Punjab. Over the past few years, the extraordinary rise of milk production made possible by the Punjab workers led to a stereotype: the holiness that cows are appointed with in India would make Punjab workers “ethnically susceptible” to perform milking. This originates from a superficial and incorrect belief. Nonetheless, it helps to stimulate a discussion about the reasons of the ability Punjabis indeed demonstrate in their work. Through the ethnographic method, it will be shown how Punjabis are qualified because they embody specific skills, displayed in Italian cowsheds, on account of the rural environment they grew up in.In Emilia-Romagna, a partire dagli anni ’90, la nicchia lavorativa deputata alla mungitura di latte vaccino è stata occupata in maniera capillare da persone provenienti dallo Stato indiano del Punjab. Gli ottimi risultati raggiunti dai lavoratori punjabi all’interno delle aziende nel corso degli anni hanno prodotto uno stereotipo: i mungitori, poiché indiani, considererebbero la vacca un animale sacro e dunque sarebbero “etnicamente predisposti” al loro lavoro. La falsa credenza è frutto di una conoscenza superficiale ed errata, ma ha il pregio di stimolare una riflessione sulle cause dell’effettiva perizia dimostrata dai mungitori punjabi. La ricerca etnografica ha messo in luce che i punjabi, provenendo in maggioranza da contesti agricoli, sono competenti perché depositari di una serie di pratiche incorporate e riprodotte nelle stalle Italiane

Plate bearing tests for working platforms

During piling and other construction works, a working platform is often constructed across the site. These platforms comprise aggregate material placed and compacted to a designed thickness. Satisfactory performance of the platform may be confirmed by a plate bearing test. Current guidance given on plate bearing testing of granular soils suggests that the plate be at least five times the nominal size of the coarsest material. For a working platform this may be large and the reaction load required from plant and resources to carry out the bearing test may become excessively high. The aim of the research presented in this paper was to investigate the effect of particle to plate size ratios to establish if the use of a smaller plate would still allow a reliable test to be performed on site. Plate bearing tests were carried out in a centrifuge using a large, coarse grained limestone. The limestone was graded to a scale representation of 6F2 material, a commonly specified particle size distribution for working platforms. The size of plate was varied and the load displacement response recorded. The measured bearing capacity was correlated with the ratio of particle to plate size

Design and development of a large shear box for testing working platform material

On large construction projects where deep foundations are to be installed, a working platform is placed across the entire site. This is comprised of a layer of aggregate (often crushed construction waste) usually with a particle size ranging from 120 mm downwards. Deep foundations are installed using heavy and tall drilling rigs and the working platform is thus safety critical to reduce the risk of machinery sinking and/or toppling which would lead to accidents and often serious injury to workers. Currently available design guidance is felt to result in conservative designs and there are many benefits to be gained from a greater understanding of the behaviour of working platform material. The design of these platforms is primarily governed by the angle of friction of the platform material. The measurement of friction angle for geomaterials that have large particle sizes is problematic (due to reasons of scale) and is often addressed by scaling down the material's grading curve prior to testing in small to medium size direct shear apparatus. The work presented here details the design of and the rationale for a large scale direct shear apparatus suitable for testing geomaterials with particle size distributions of the type that would be utilised in working platforms

Stability of Working Platforms for Tracked Plant

The aim of this research is to improve the design of working platforms for tracked plant in order to guarantee safety but also a more economical approach to the design. The reason for this concern derives in part from incidents of overturning plant which have taken place in the past, some of them resulting in injuries and/or death of operatives, but also from the consequent use of excessively conservative and therefore uneconomical design. Common practice for the design of working platforms is the use of bearing capacity methods normally adopted for the construction of spread foundations. The objective of this approach is the definition of an appropriate platform thickness which is back calculated from a bearing capacity equation. According to this type of design, the thickness of the platform changes based on the characteristics of the platform material and of the subgrade. Among these factors, the one having more influence on the resulting thickness is the design angle of friction of the platform material, which therefore need to be accurately established. A common laboratory method used to measure the angle of friction of soils is the direct shear test. Difficulties in the correct interpretation of the results of this test are mainly associated with the presence of scale effects. As extensively reported by literature, scale effects can derive from testing material with a large particle size which is not suitable for testing in a standard apparatus, that would cause the shear strength of the material to be overestimated. A solution to this issue often consists of testing a scaled sample of the material using the standard apparatus. Nonetheless, even this approach can induce scale effects leading to an underestimation of the angle of friction when an important reduction in particle size is produced. Another method used to derive the angle of friction of the platform material is the plate bearing capacity test which is normally conducted on site. In order to guarantee reliable results for the bearing capacity of the material and the derived angle of friction, an appropriate ratio between plate diameter and particle size must be used. The problem of this method is associated with the high costs of the testing apparatus which are substantially increased by the large particle size of the material requiring large plate diameters to be used during the test and consequently high reaction forces to be applied. In order to investigate the scale effects associated with testing the material at smaller scale using the standard shear box apparatus and with using different plate diameters in case of plate loading tests, a series of small scale direct shear tests and plate loading test using a centrifuge model were conducted on two small scale samples of crushed limestone. The results of these tests were used to derive the angle of friction of the material and were compared with the ones obtained from testing the same material at full scale using a large shear box apparatus which was designed and manufactured for the purpose of this research. Comparison of the results allowed to identify the magnitude of the scale effects on the value of the angle of friction of the material. Differences in results should be taken into account in order to define an appropriate value for the design

Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne.

BackgroundTreatment for both facial and truncal acne has not sufficiently been studied.ObjectivesTo evaluate the long-term safety and efficacy of trifarotene in both facial and truncal acne.MethodsIn a multicentre, open-label, 52-week study, patients with moderate facial and truncal acne received trifarotene 50 μg/g cream (trifarotene). Assessments included local tolerability, safety, investigator and physician's global assessments (IGA, PGA) and quality of life (QOL). A validated QOL questionnaire was completed by the patient at Baseline, Week 12, 26 and 52/ET.ResultsOf 453 patients enrolled, 342 (75.5%) completed the study. Trifarotene-related treatment-emergent adverse events (TEAEs) were reported in 12.6% of patients, and none was serious. Most related TEAEs were cutaneous and occurred during the first 3 months. Signs and symptoms of local tolerability were mostly mild or moderate and severe signs, and symptoms were reported for 2.2% to 7.1% of patients for the face and 2.5% to 5.4% for the trunk. Local irritation increased during the first week of treatment on the face and up to Weeks 2 to 4 on the trunk with both decreasing thereafter. At Week 12, IGA and PGA success rates were 26.6% and 38.6%, respectively. Success rates increased to 65.1% and 66.9%, respectively at Week 52. Overall success (both IGA and PGA success in the same patient) was 57.9% at Week 52. At Week 52 visit, 92/171 (53.8%) patients who had completed their assessments had scores from 0 to 1 (i.e. no effect of acne on their QOL) vs. 47/208 (22.6%) patients at Baseline visit.ConclusionIn this 52-week study, trifarotene was safe, well tolerated and effective in moderate facial and truncal acne

Generation of Biologically Active Angiostatin Kringle 1–3 by Activated Human Neutrophils

AbstractThe contribution of polymorphonuclear neutrophils (PMN) to host defense and natural immunity extends well beyond their traditional role as professional phagocytes. In this study, we demonstrate that upon stimulation with proinflammatory stimuli, human PMN release enzymatic activities that, in vitro, generate bioactive angiostatin fragments from purified plasminogen. We also provide evidence that these angiostatin-like fragments, comprising kringle domain 1 to kringle domain 3 (kringle 1–3) of plasminogen, are generated as a byproduct of the selective proteolytic activity of neutrophil-secreted elastase. Remarkably, affinity-purified angiostatin kringle 1–3 fragments generated by neutrophils inhibited basic fibroblast growth factor plus vascular endothelial growth factor-induced endothelial cell proliferation in vitro, and both vascular endothelial growth factor-induced angiogenesis in the matrigel plug assay and fibroblast growth factor-induced angiogenesis in the chick embryo chorioallantoic membrane assay, in vivo. These results represent the first demonstration that biologically active angiostatin-like fragments can be generated by inflammatory human neutrophils. Because angiostatin is a potent inhibitor of angiogenesis, tumor growth, and metastasis, the data suggest that activated PMN not only act as potent effectors of inflammation, but might also play a critical role in the inhibition of angiogenesis in inflammatory diseases and tumors, by generation of a potent anti-angiogenic molecule

Fixed-Combination Halobetasol Propionate and Tazarotene in the Treatment of Psoriasis: Narrative Review of Mechanisms of Action and Therapeutic Benefits

Psoriasis is a lifelong disease associated with cycles of remission and relapse. Topical treatments are the front line of psoriasis therapy for most patients and have antiproliferative, anti-inflammatory, and immunosuppressive mechanisms of action. Novel fixed-dose combinations of topical therapeutic agents are becoming increasingly available, leveraging multiple mechanisms of action to improve safety and efficacy with formulations that are easier to use and may allow for the use of lower doses of active ingredients. A fixed-combination lotion containing the potent-to-super-potent corticosteroid halobetasol propionate (HP) and the retinoid tazarotene (HP 0.01%/TAZ 0.045%) was recently developed using polymeric emulsion technology. This new formulation technology allows for more uniform and efficient delivery of the active ingredients at lower doses than conventional monotherapy formulations of either ingredient while providing enhanced hydration and moisturization. This review provides an up-to-date overview of the therapeutic mechanisms of action of HP and TAZ, the rationale behind the development of HP 0.01%/TAZ 0.045% lotion, and clinical trials data on the efficacy, safety and tolerability, and maintenance of therapeutic effect with HP 0.01%/TAZ 0.045% lotion in the treatment of moderate-to-severe plaque psoriasis

The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia

The combination of Simvastatin and Ezetimibe allows dual inhibition of both cholesterol production and absorption. This treatment approach allows achieving same low serum cholesterol levels with the administration of much lower doses of statins. This should reduce side effects, compared to statin only therapy, enabling more patients to achieve their LDL cholesterol treatment goals. With ezetimibe/simvastatin therapy, reductions of about 60% from baseline in LDL cholesterol have been shown. Concomitant improvement in other lipid fractions have also been demonstrated. The ezetimibe/simvastatin combination has been well tolerated, with a safety profile similar to that of statin therapy. This article will review clinical experience with ezetimibe/simvastatin combination, commenting upon its place and potential value in the prevention of cardiovascular disease

TRASER - Total Reflection Amplification of Spontaneous Emission of Radiation

Background and Objective: Light and lasers in medical therapy have made dramatic strides since their invention five decades ago. However, the manufacture of lasers can be complex and expensive which often makes treatments limited and costly. Further, no single laser will provide the correct parameters to treat all things. Hence, laser specialists often need multiple devices to practice their specialty. A new concept is described herein that has the potential to replace many lasers and light sources with a single ‘tunable ’ device. Study Design/Material and Methods: This device amplifies spontaneous emission of radiation by capturing and retaining photons through total internal reflection, hence the acronym Total Reflection Amplification of Spontaneous Emission of Radiation, or TRASER. Results: Specific peaks of light can be produced in a reproducible manner with high peak powers of variable pulse durations, a large spot size, and high repetition rate. Conclusion: Considering the characteristics and parameters of Traser technology, it is possible that this one device woul

Improvements in Acne and Skin Oiliness with Tazarotene 0.045% Lotion in Patients with Oily Skin

BACKGROUND: Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequalae. OBJECTIVE: Evaluate efficacy, changes in skin oiliness, and safety with tazarotene 0.045% lotion in participants with moderate-to-severe acne and oily skin. METHODS: In two phase 3, double-blind, 12-week studies (NCT03168321; NCT03168334), participants aged ≥9 years with moderate-to-severe acne were randomized 1:1 to once-daily tazarotene 0.045% lotion or vehicle lotion (N = 1,614). This pooled, post hoc analysis included only participants self-categorized with oily skin at baseline on the Acne Quality of Life questionnaire item 19 (scores: 0 [extremely oily] to 6 [not at all oily]). Inflammatory/noninflammatory lesion counts, treatment success, skin oiliness, treatment-emergent adverse events (TEAEs), and cutaneous safety/tolerability were evaluated. RESULTS: In all participants with oily skin (n = 793), tazarotene provided greater reductions in inflammatory/noninflammatory lesions (P \u3c 0.001, both) and greater treatment success rates versus vehicle (P \u3c 0.01) at week 12. Over two-thirds of polymeric lotion-treated participants had subjective skin oiliness reductions by week 12, with around a third reporting \u27low/not\u27 oily skin. Tazarotene TEAE rates were similar to the overall population. CONCLUSION: Once-daily treatment with tazarotene 0.045% polymeric emulsion lotion may help improve patient-perceived skin oiliness in those with moderate-to-severe acne