724 research outputs found
Development of a novel in vitro insulin resistance model in primary human tenocytes for diabetic tendinopathy research
Promoting a Lower Carbon Footprint using an Enhanced Pedestrian-Friendly Model
Walking has significantly contributed to a lower carbon emission of a country. With the aspiration of a lesser carbon footprint zone, the initiatives of understanding the current pedestrian system are crucial. Although walking improves green mobility, it is still known as the least preferred mode. Thus, this study aims to improve pedestrian walkways and promote a higher level of usage of pedestrian walkways by analyzing the critical factors contributing to the lower carbon footprint among the urban dwellers. The results will help to improve a lower carbon footprint practice in the metropolitan area.Keywords: Pedestrian,Friendly,Low Carbon,SatisfactioneISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.198
Spontaneous Subtle Expression Detection and Recognition based on Facial Strain
Optical strain is an extension of optical flow that is capable of quantifying
subtle changes on faces and representing the minute facial motion intensities
at the pixel level. This is computationally essential for the relatively new
field of spontaneous micro-expression, where subtle expressions can be
technically challenging to pinpoint. In this paper, we present a novel method
for detecting and recognizing micro-expressions by utilizing facial optical
strain magnitudes to construct optical strain features and optical strain
weighted features. The two sets of features are then concatenated to form the
resultant feature histogram. Experiments were performed on the CASME II and
SMIC databases. We demonstrate on both databases, the usefulness of optical
strain information and more importantly, that our best approaches are able to
outperform the original baseline results for both detection and recognition
tasks. A comparison of the proposed method with other existing spatio-temporal
feature extraction approaches is also presented.Comment: 21 pages (including references), single column format, accepted to
Signal Processing: Image Communication journa
A METHOD AND A CONNECTING DEVICE FOR ASSOCIATING USERS AND PHILANTHROPIC ENTITIES
The present disclosure relates to a method and a connecting device for associating users and philanthropic entities to help in community movement. In the present disclosure, initially a connecting device 103 may receive a request from an authorization entity to connect to a philanthropic entity 105. The authorization entity may send the request to the connecting device 103 when the user device 101 initiates a transaction with a merchant. The authorization entity may determine if the user device 101 is enrolled in the charity program. Further, the connecting device 103 may send a request to retrieve the event data associated with the charity program to philanthropic entity 105. The connecting device 103 may further transmit the retrieved event data associated with the charity program to the user device 101. Finally, the connecting device 103 triggers the contribution as charity to the philanthropic entity 105 based on the received response
Towards Sustainable Ultrawide Bandgap Van der Waals Materials: An ab initio Screening Effort
The sustainable development of next-generation device technology is paramount
in the face of climate change and the looming energy crisis. Tremendous efforts
have been made in the discovery and design of nanomaterials that achieve
device-level sustainability, where high performance and low operational energy
cost are prioritized. However, many of such materials are composed of elements
that are under threat of depletion and pose elevated risks to the environment.
The role of material-level sustainability in computational screening efforts
remains an open question thus far. Here we develop a general van der Waals
materials screening framework imbued with sustainability-motivated search
criteria. Using ultrawide bandgap (UWBG) materials as a backdrop -- an emerging
materials class with great prospects in dielectric, power electronics, and
ultraviolet device applications, we demonstrate how this screening framework
results in 25 sustainable UWBG layered materials comprising only of low-risks
elements. Our findings constitute a critical first-step towards reinventing a
more sustainable electronics landscape beyond silicon, with the framework
established in this work serving as a harbinger of sustainable 2D materials
discovery.Comment: 15 pages, 8 figure
The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties
BACKGROUND The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden or Tiger milk mushroom (Polyporales, Basidiomycota) is a valuable folk medicine for indigenous peoples in Southeast Asia. Despite the increasing interest in this ethnobotanical mushroom, very little is known about the molecular and genetic basis of its medicinal and nutraceutical properties. RESULTS The de novo assembled 34.3 Mb L. rhinocerotis genome encodes 10,742 putative genes with 84.30% of them having detectable sequence similarities to others available in public databases. Phylogenetic analysis revealed a close evolutionary relationship of L. rhinocerotis to Ganoderma lucidum, Dichomitus squalens, and Trametes versicolor in the core polyporoid clade. The L. rhinocerotis genome encodes a repertoire of enzymes engaged in carbohydrate and glycoconjugate metabolism, along with cytochrome P450s, putative bioactive proteins (lectins and fungal immunomodulatory proteins) and laccases. Other genes annotated include those encoding key enzymes for secondary metabolite biosynthesis, including those from polyketide, nonribosomal peptide, and triterpenoid pathways. Among them, the L. rhinocerotis genome is particularly enriched with sesquiterpenoid biosynthesis genes. CONCLUSIONS The genome content of L. rhinocerotis provides insights into the genetic basis of its reported medicinal properties as well as serving as a platform to further characterize putative bioactive proteins and secondary metabolite pathway enzymes and as a reference for comparative genomics of polyporoid fungi.This research is supported by High Impact Research Grant UM.C/625/1/HIR/
MoE/E20040-20001 from the University of Malaya/Ministry of Education,
Malaysia. H-YYY is supported by the postgraduate research grant (PPP) PV024/
2012A from University of Malaya, Malaysia. Y-HC is a recipient of Australian Research
Council Discovery Early Career Researcher Award (ARC DECRA)
The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties
BACKGROUND: The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden or Tiger milk mushroom (Polyporales, Basidiomycota) is a valuable folk medicine for indigenous peoples in Southeast Asia. Despite the increasing interest in this ethnobotanical mushroom, very little is known about the molecular and genetic basis of its medicinal and nutraceutical properties. RESULTS: The de novo assembled 34.3 Mb L. rhinocerotis genome encodes 10,742 putative genes with 84.30% of them having detectable sequence similarities to others available in public databases. Phylogenetic analysis revealed a close evolutionary relationship of L. rhinocerotis to Ganoderma lucidum, Dichomitus squalens, and Trametes versicolor in the core polyporoid clade. The L. rhinocerotis genome encodes a repertoire of enzymes engaged in carbohydrate and glycoconjugate metabolism, along with cytochrome P450s, putative bioactive proteins (lectins and fungal immunomodulatory proteins) and laccases. Other genes annotated include those encoding key enzymes for secondary metabolite biosynthesis, including those from polyketide, nonribosomal peptide, and triterpenoid pathways. Among them, the L. rhinocerotis genome is particularly enriched with sesquiterpenoid biosynthesis genes. CONCLUSIONS: The genome content of L. rhinocerotis provides insights into the genetic basis of its reported medicinal properties as well as serving as a platform to further characterize putative bioactive proteins and secondary metabolite pathway enzymes and as a reference for comparative genomics of polyporoid fungi. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/1471-2164-15-635) contains supplementary material, which is available to authorized users
Recommended from our members
Roles and recommendations from primary care physicians towards managing low-risk breast cancer survivors in a shared-care model with specialists in Singapore-a qualitative study.
BackgroundBreast cancer is prevalent and has high cure rates. The resultant increase in numbers of breast cancer survivors (BCS) may overwhelm the current oncology workforce in years to come. We postulate that primary care physicians (PCPs) could play an expanded role in comanaging survivors, provided they are given the appropriate tools and training to do so.ObjectiveTo explore the perspectives of PCPs towards managing BCS in a community-based shared-care programme with oncologists.MethodsEleven focus groups and six in-depth interviews were conducted with seventy PCPs recruited by purposive sampling. All sessions were audio-recorded, transcribed verbatim and coded by three independent investigators. Thematic data analysis was performed and the coding process facilitated by NVivo 12.ResultsMajority of PCPs reported currently limited roles in managing acute and non-cancer issues, optimizing comorbidities and preventive care. PCPs aspired to expand their role to include cancer surveillance, risk assessment and addressing unmet psychosocial needs. PCPs preferred to harmonize cancer survivorship management of their primary care patients who are also BCS, with defined role distinct from oncologists. Training to understand the care protocol, enhancement of communication skills, confidence and trust were deemed necessary. PCPs proposed selection criteria of BCS and adequacy of their medical information; increased consultation time; contact details and timely access to oncologists (if needed) in the shared-care programme.ConclusionsPCPs were willing to share the care of BCS with oncologists but recommended role definition, training, clinical protocol, resources and access to oncologist's consultation to optimize the programme implementation
Extraction and physicochemical characterization of chitin and chitosan from Zophobas morio larvae in varying sodium hydroxide concentration
Large amount of sodium hydroxide (NaOH) is consumed to remove the protein content in chitin biomass during deproteinization. However, excessive NaOH concentration used might lead to the reduction of cost effectiveness during chitin extraction. Hence, the present study aimed to extract and evaluate the physicochemical properties of chitin and chitosan isolated from superworm (Zophobas morio) larvae using 0.5 M–2.0 M of NaOH. The extracted chitin and chitosan were subjected to Fourier Transform Infrared Spectroscopy (FT-IR), elemental analysis, Scanning Electron Microscope (SEM), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and X-ray Diffraction (XRD). The 0.5 M NaOH treatment resulted in the highest yield of chitin (5.43%), but produced the lowest yield (65.84%) of chitosan. The extracted chitin samples had relatively high degree of acetylation (DA) (82.39%-101.39%). Both chitin and chitosan showed smooth surface with tiny pores. The extracted chitin samples were confirmed as α-chitin based on the FT-IR and TGA. The chitin samples were amorphous with low degree of crystallinity. From TGA, the Chitosan 3 extracted was partially deacetylated. Both DPPH radical scavenging and ferric-chelating assay showed positive correlation with DD of chitosan isolates. However, the chitosan isolates were not fully dissolved, resulting in lower radical scavenging and ferric-chelating ability compared to commercial chitosan
- …