Type-enhanced Ensemble Triple Representation via Triple-aware Attention for Cross-lingual Entity Alignment

Entity alignment(EA) is a crucial task for integrating cross-lingual and cross-domain knowledge graphs(KGs), which aims to discover entities referring to the same real-world object from different KGs. Most existing methods generate aligning entity representation by mining the relevance of triple elements via embedding-based methods, paying little attention to triple indivisibility and entity role diversity. In this paper, a novel framework named TTEA -- Type-enhanced Ensemble Triple Representation via Triple-aware Attention for Cross-lingual Entity Alignment is proposed to overcome the above issues considering ensemble triple specificity and entity role features. Specifically, the ensemble triple representation is derived by regarding relation as information carrier between semantic space and type space, and hence the noise influence during spatial transformation and information propagation can be smoothly controlled via specificity-aware triple attention. Moreover, our framework uses triple-ware entity enhancement to model the role diversity of triple elements. Extensive experiments on three real-world cross-lingual datasets demonstrate that our framework outperforms state-of-the-art methods

OTIEA:Ontology-enhanced Triple Intrinsic-Correlation for Cross-lingual Entity Alignment

Cross-lingual and cross-domain knowledge alignment without sufficient external resources is a fundamental and crucial task for fusing irregular data. As the element-wise fusion process aiming to discover equivalent objects from different knowledge graphs (KGs), entity alignment (EA) has been attracting great interest from industry and academic research recent years. Most of existing EA methods usually explore the correlation between entities and relations through neighbor nodes, structural information and external resources. However, the complex intrinsic interactions among triple elements and role information are rarely modeled in these methods, which may lead to the inadequate illustration for triple. In addition, external resources are usually unavailable in some scenarios especially cross-lingual and cross-domain applications, which reflects the little scalability of these methods. To tackle the above insufficiency, a novel universal EA framework (OTIEA) based on ontology pair and role enhancement mechanism via triple-aware attention is proposed in this paper without introducing external resources. Specifically, an ontology-enhanced triple encoder is designed via mining intrinsic correlations and ontology pair information instead of independent elements. In addition, the EA-oriented representations can be obtained in triple-aware entity decoder by fusing role diversity. Finally, a bidirectional iterative alignment strategy is deployed to expand seed entity pairs. The experimental results on three real-world datasets show that our framework achieves a competitive performance compared with baselines

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Abstract: Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria

Implicit User Modeling for Personalized Search

Information retrieval systems (e.g., web search engines) are critical for overcoming information overload. A major deficiency of existing retrieval systems is that they generally lack user modeling and are not adaptive to individual users, resulting in inherently non-optimal retrieval performance. For example, a tourist and a programmer may use the same word ``java'' to search for different information, but the current search systems would return the same results. In this paper, we study how to infer a user's interest from the user's search context and use the inferred implicit user model for personalized search to improve retrieval accuracy. We present a decision theoretic framework and develop techniques for implicit user modeling in information retrieval. We develop an intelligent client-side web search agent (UCAIR) that can perform eager implicit feedback, e.g., query expansion based on previous queries and immediate result reranking based on clickthrough information. Experiments on web search show that our search agent can improve search accuracy over a popular existing search engine

Search Logs as Information Footprints: Supporting Guided Navigation for Exploratory Search

While current search engines serve known-item search such as homepage finding very well, they generally cannot support exploratory search effectively. In exploratory search, users do not know their information needs precisely and also often lack the needed knowledge to formulate effective queries, thus querying alone, as supported by the current search engines, is insufficient, and browsing into related information would be very useful. In this paper, we present a formal navigation-based retrieval framework to unify querying and browsing and treat both as navigation over topic regions. To support browsing effectively, we treat search logs as "footprints" left by previous users in the information space and build a multi-resolution topic map to guide a user in navigating in the information space. To test the effectiveness of the proposed methods, we build a prototype system based on a small sample of search logs and a commercial search engine. Our experiment results show that the proposed navigation-based framework is promising and the proposed methods for guided navigation are effective

PAPER Privacy Protection in Personalized Search

Personalized search is a promising way to improve the accuracy of web search, and has been attracting much attention recently. However, effective personalized search requires collecting and aggregating user information, which often raise serious concerns of privacy infringement for many users. Indeed, these concerns have become one of the main barriers for deploying personalized search applications, and how to do privacy-preserving personalization is a great challenge. In this paper, we systematically examine the issue of privacy preservation in personalized search. We distinguish and define four levels of privacy protection, and analyze various software architectures for personalized search. We show that client-side personalization has advantages over the existing server-side personalized search services in preserving privacy, and envision possible future strategies to fully protect user privacy.