Comparison of cavitation erosion rate with liquid impingement erosion rate.

Both cavitation erosion and liquid impingement erosion are phenomena that can cause pipe wall thinning in power plants. The Code for Power Generation Facilities, Rules on Pipe Wall Thinning Management, was published by the JSME (Japan Society of Mechanical Engineers) in 2005. The code says that cavitation erosion shall be prevented either in the design stage or by daily inspection. On the other hand, liquid impingement erosion can occur in any location where a working fluid attacks a pipe wall at high flow velocities. Therefore, it is very important to evaluate the amount of erosion by liquid impingement for pipe steels quantitatively from the viewpoint of aging management. In this study, we carried out both cavitation erosion and liquid impingement erosion tests, and clarified the relation between the two erosion rates. As a result, we found that the erosion rate by cavitation increases in proportion with the 5.2th to 6.8th power of the flow velocity and that by liquid impingement with the 6.0th to 7.4th power. Moreover, a good correlation was obtained between erosion rates by cavitation and by liquid impingement. We also discussed the erosion mechanism with SEM photography, and proposed an erosion model.http://deepblue.lib.umich.edu/bitstream/2027.42/84233/1/CAV2009-final32.pd

Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles

<p>Abstract</p> <p>Background</p> <p>Mild hypophosphatasia (HPP) phenotype may result from <it>ALPL </it>gene mutations exhibiting residual alkaline phosphatase activity or from severe heterozygous mutations exhibiting a dominant negative effect. In order to determine the cause of our failure to detect a second mutation by sequencing in patients with mild HPP and carrying on a single heterozygous mutation, we tested the possible dominant effect of 35 mutations carried by these patients.</p> <p>Methods</p> <p>We tested the mutations by site-directed mutagenesis. We also genotyped 8 exonic and intronic <it>ALPL </it>gene polymorphisms in the patients and in a control group in order to detect the possible existence of a recurrent intronic mild mutation.</p> <p>Results</p> <p>We found that most of the tested mutations exhibit a dominant negative effect that may account for the mild HPP phenotype, and that for at least some of the patients, a second mutation in linkage disequilibrium with a particular haplotype could not be ruled out.</p> <p>Conclusion</p> <p>Mild HPP results in part from compound heterozygosity for severe and moderate mutations, but also in a large part from heterozygous mutations with a dominant negative effect.</p

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Postoperative blood pressure deficit and acute kidney injury progression in vasopressor-dependent cardiovascular surgery patients

BACKGROUND: In vasopressor-dependent patients who had undergone cardiovascular surgery, we examined whether those with progression of acute kidney injury (AKI) had a greater difference (deficit) between premorbid and within-ICU hemodynamic pressure-related parameters compared to those without AKI progression. METHODS: We assessed consecutive adults who underwent cardiovascular surgery and who stayed in our ICU for at least 48 hours and received vasopressor support for more than 4 hours. We obtained premorbid and vasopressor-associated, time-weighted average values for hemodynamic pressure-related parameters (systolic [SAP], diastolic [DAP], and mean arterial pressure [MAP]; central venous pressure [CVP], mean perfusion pressure [MPP], and diastolic perfusion pressure [DPP]) and calculated deficits in those values. We defined AKI progression as an increase of at least one Kidney Disease: Improving Global Outcomes stage. RESULTS: We screened 159 patients who satisfied the inclusion criteria and identified 76 eligible patients. Thirty-six patients (47%) had AKI progression. All achieved pressure-related values were similar between patients with or without AKI progression. However, deficits in DAP (P = 0.027), MPP (P = 0.023), and DPP (P = 0.002) were significantly greater in patients with AKI progression. CONCLUSIONS: Patients with AKI progression had greater DAP, MPP, and DPP deficits compared to patients without AKI progression. Such deficits might be modifiable risk factors for the prevention of AKI progression

IMMUNOSENSOR SYSTEMS USING LIPOSOMES AND PLANAR LIPID BILAYER MEMBRANES FOR ION-CHANNEL MODEL SENSORS

For the purpose of constructing a new biosensor which mimics the concept of "ion-channel", two approaches were examined: l)liposome systems, and 2)planar lipid bilayer membrane systems. In both cases, some interaction such as immunoreaction, electrostatruneh dıpole,sand hydrophobic interaction of a stimulus with a model receptor site at the surface of lipid membranes triggers the change in permeation of marker ions across the lipid bilayer membranes. This change in permeation of the marker ions is subsequently monitored electrochemically, which is a direct but much amplified measure of the analyte to be assayed