GBF - Gesellschaft für Biotechnologische Forschung
Abstract
For the purpose of constructing a new biosensor which mimics the
concept of "ion-channel", two approaches were examined: l)liposome
systems, and 2)planar lipid bilayer membrane systems. In both cases,
some interaction such as immunoreaction, electrostatruneh dıpole,sand
hydrophobic interaction of a stimulus with a model receptor site at the
surface of lipid membranes triggers the change in permeation of marker
ions across the lipid bilayer membranes. This change in permeation of
the marker ions is subsequently monitored electrochemically, which is a
direct but much amplified measure of the analyte to be assayed
