Espacialização da pecuária de corte sul-mato-grossense.

A economia do Estado de Mato Grosso do Sul baseia-se principalmente na agricultura e pecuária, e o estado é subdivido em quatro mesorregiões: Centro-Norte, Pantanal, Sudoeste e Leste. Para espacializar a produção da pecuária bovina sul-mato-grossense, foram usados dados censitários e geocódigos municipais do IBGE e procedimentos do sistema de informação geográfica (SIG). As mesorregiões Leste e Sudoeste comportam o maior número de cabeças, da ordem de seis milhões. A mesorregião do Pantanal possui imensas áreas alagadas e favorece a exploração extensiva, e a mesorregião Centro-Norte, localizada mais próxima aos grandes mercados consumidores, têm cerca de quatro milhões de cabeças. A taxa geométrica de crescimento (TGC) do rebanho bovino de 2006 a 2011 apresenta padrão irregular, com variação de -6,86 a +7,31, -5,60 a +13,33, -2,65 a +6,65 e -5,15 a +2,45 para as regiões Pantanal, Centro-Norte, Sudoeste e Leste, respectivamente. Em termos nacionais, as projeções da TGC (2007 a 2023) para consumo e exportação são da ordem de 30% e 22,4%, respectivamente, enquanto a TGC para produção nesse mesmo período é da ordem de 18,4%. Esses números representam menos oferta interna e potencial aquecimento dos preços domésticos, contribuindo, assim, para um possível aumento da taxa de inflação no período analisado

Euclid: Superluminous supernovae in the Deep Survey

Context. In the last decade, astronomers have found a new type of supernova called superluminous supernovae (SLSNe) due to their high peak luminosity and long light-curves. These hydrogen-free explosions (SLSNe-I) can be seen to z ~ 4 and therefore, offer the possibility of probing the distant Universe. Aims. We aim to investigate the possibility of detecting SLSNe-I using ESA’s Euclid satellite, scheduled for launch in 2020. In particular, we study the Euclid Deep Survey (EDS) which will provide a unique combination of area, depth and cadence over the mission. Methods. We estimated the redshift distribution of Euclid SLSNe-I using the latest information on their rates and spectral energy distribution, as well as known Euclid instrument and survey parameters, including the cadence and depth of the EDS. To estimate the uncertainties, we calculated their distribution with two different set-ups, namely optimistic and pessimistic, adopting different star formation densities and rates. We also applied a standardization method to the peak magnitudes to create a simulated Hubble diagram to explore possible cosmological constraints. Results. We show that Euclid should detect approximately 140 high-quality SLSNe-I to z ~ 3.5 over the first five years of the mission (with an additional 70 if we lower our photometric classification criteria). This sample could revolutionize the study of SLSNe-I at z > 1 and open up their use as probes of star-formation rates, galaxy populations, the interstellar and intergalactic medium. In addition, a sample of such SLSNe-I could improve constraints on a time-dependent dark energy equation-of-state, namely w(a), when combined with local SLSNe-I and the expected SN Ia sample from the Dark Energy Survey. Conclusions. We show that Euclid will observe hundreds of SLSNe-I for free. These luminous transients will be in the Euclid data-stream and we should prepare now to identify them as they offer a new probe of the high-redshift Universe for both astrophysics and cosmology.Acknowledgements. We thank the internal EC referees (P. Nugent and J. Brichmann) as well as the many comments from our EC colleagues and friends. C.I. thanks Chris Frohmaier and Szymon Prajs for useful discussions about supernova rates. C.I. and R.C.N. thank Mark Cropper for helpful information about the V IS instrument. C.I. thanks the organisers and participants of the Munich Institute for Astro- and Particle Physics (MIAPP) workshop “Superluminous supernovae in the next decade” for stimulating discussions and the provided online material. The Euclid Consortium acknowledges the European Space Agency and the support of a number of agencies and institutes that have supported the development of Euclid. A detailed complete list is available on the Euclid web site (http://www.euclid-ec.org). In particular the Agenzia Spaziale Italiana, the Centre National dEtudes Spatiales, the Deutsches Zentrum für Luft- and Raumfahrt, the Danish Space Research Institute, the Fundação para a Ciênca e a Tecnologia, the Ministerio de Economia y Competitividad, the National Aeronautics and Space Administration, The Netherlandse Onderzoekschool Voor Astronomie, the Norvegian Space Center, the Romanian Space Agency, the State Secretariat for Education, Research and Innovation (SERI) at the Swiss Space Office (SSO), the United Kingdom Space Agency, and the University of Helsinki. R.C.N. acknowledges partial support from the UK Space Agency. D.S. acknowledges the Faculty of Technology of the University of Portsmouth for support during his PhD studies. C.I. and S.J.S. acknowledge funding from the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement No. [291222]. C.I. and M.S. acknowledge support from EU/FP7-ERC grant No. [615929]. E.C. acknowledge financial contribution from the agreement ASI/INAF/I/023/12/0. The work by KJ and others at MPIA on NISP was supported by the Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR) under grant 50QE1202. M.B. and S.C. acknowledge financial contribution from the agreement ASI/INAF I/023/12/1. R.T. acknowledges funding from the Spanish Ministerio de Economía y Competitividad under the grant ESP2015-69020-C2- 2-R. I.T. acknowledges support from Fundação para a Ciência e a Tecnologia (FCT) through the research grant UID/FIS/04434/2013 and IF/01518/2014. J.R. was supported by JPL, which is run under a contract for NASA by Caltech and by NASA ROSES grant 12-EUCLID12-0004

Alterações antropogênicas nos remanescentes de vegetação natural (RVN) de savana do estado de São Paulo no ano de 2009.

Deforestation in São Paulo State was mainly driven by sugarcane and coffee crops during the XVIII and XIX centuries which caused a significant fragmentation in native forests. More recently, between the 1970?s and 1980?s decades the native forest fragmentation process was intensified and also the savannah area was drastically reduced due to sugarcane expansion for ethanol production. Much native vegetation was deteriorated and fragmented into smaller disconnected portions during this period. This work was performed within the scope of a technical cooperative agreement between the Environmental Secretary of São Paulo State (SMA) and the National Institute for Space Research (INPE). It consisted in monitoring monthly the land cover changes of 7,000 polygons of remanescent native vegetation (RVN) in the São Paulo State. The environmental assessment of the vegetation cover status was performed based on mesoregions for better discussion of the geographical distribution of the deforested RVN's from May to December 2009. The results showed that Bauru and Ribeirão Preto mesoregions presented the highest land cover changes with 19.4 and 12.1 km², respectively

Aid conditionalities, international Good Manufacturing Practice standards and local production rights: a case study of local production in Nepal

© 2015 Brhlikova et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.This work was supported by the Economic and Social Research Council and the Department for International Development [RES-167-25-0110] through the collaborative research project Tracing Pharmaceuticals in South Asia (2006 – 2009). In addition to the authors of this paper, the project team included: Soumita Basu, Gitanjali Priti Bhatia, Erin Court, Abhijit Das, Stefan Ecks, Patricia Jeffery, Roger Jeffery, Rachel Manners, and Liz Richardson. Martin Chautari (Kathmandu) and the Centre for Health and Social Justice (New Delhi) provided resources drawn upon in writing this paper but are not responsible for the views expressed, nor are ESRC or DFID. Ethical review was provided by the School of Social and Political Science at the University of Edinburgh, and ethical approval in Nepal for the study granted by the Nepal Health Research Council (NHRC)

An essential function for the ATR-Activation-Domain (AAD) of TopBP1 in mouse development and cellular senescence

ATR activation is dependent on temporal and spatial interactions with partner proteins. In the budding yeast model, three proteins – Dpb11TopBP1, Ddc1Rad9 and Dna2 - all interact with and activate Mec1ATR. Each contains an ATR activation domain (ADD) that interacts directly with the Mec1ATR:Ddc2ATRIP complex. Any of the Dpb11TopBP1, Ddc1Rad9 or Dna2 ADDs is sufficient to activate Mec1ATR in vitro. All three can also independently activate Mec1ATR in vivo: the checkpoint is lost only when all three AADs are absent. In metazoans, only TopBP1 has been identified as a direct ATR activator. Depletion-replacement approaches suggest the TopBP1-AAD is both sufficient and necessary for ATR activation. The physiological function of the TopBP1 AAD is, however, unknown. We created a knock-in point mutation (W1147R) that ablates mouse TopBP1-AAD function. TopBP1-W1147R is early embryonic lethal. To analyse TopBP1-W1147R cellular function in vivo, we silenced the wild type TopBP1 allele in heterozygous MEFs. AAD inactivation impaired cell proliferation, promoted premature senescence and compromised Chk1 signalling following UV irradiation. We also show enforced TopBP1 dimerization promotes ATR-dependent Chk1 phosphorylation. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development

NEXT-100 Technical Design Report (TDR). Executive Summary

In this Technical Design Report (TDR) we describe the NEXT-100 detector that will search for neutrinoless double beta decay (bbonu) in Xe-136 at the Laboratorio Subterraneo de Canfranc (LSC), in Spain. The document formalizes the design presented in our Conceptual Design Report (CDR): an electroluminescence time projection chamber, with separate readout planes for calorimetry and tracking, located, respectively, behind cathode and anode. The detector is designed to hold a maximum of about 150 kg of xenon at 15 bar, or 100 kg at 10 bar. This option builds in the capability to increase the total isotope mass by 50% while keeping the operating pressure at a manageable level. The readout plane performing the energy measurement is composed of Hamamatsu R11410-10 photomultipliers, specially designed for operation in low-background, xenon-based detectors. Each individual PMT will be isolated from the gas by an individual, pressure resistant enclosure and will be coupled to the sensitive volume through a sapphire window. The tracking plane consists in an array of Hamamatsu S10362-11-050P MPPCs used as tracking pixels. They will be arranged in square boards holding 64 sensors (8 times8) with a 1-cm pitch. The inner walls of the TPC, the sapphire windows and the boards holding the MPPCs will be coated with tetraphenyl butadiene (TPB), a wavelength shifter, to improve the light collection.Comment: 32 pages, 22 figures, 5 table