The establishment of the right to change the registration name and sex by the self-perception of gender in Brazilian civil rights

This article addresses the right of persons who do not identify themselves with their registered sex to change it, as well as their first names in the public records, adapting them to their self-perceived gender. The practical difficulties that the non-publication of the entire content of the Brazilian Supreme Court decision, which allowed that change in a comprehensive manner to all citizens, caused for the establishment of this right when facing the Civil Registries is also taken into account. Another issue is the solution given administratively in a pioneering way by the Ceará Court of Justice and, later, by the National Council of Justice, when publishing regulatory proceedings directly in the public registries, in a relatively simple and safe way. A brief comparative analysis will be carried out between the Ceará provision and the National provision. The deductive method will be used, starting from some legal norms, and, mainly, the provisions of the Ceará Court of Justice and the National Council of Justice, with analysis of its commands. A theoretical qualitative research line will be adopted, with an analysis of bibliographic sources, as well as laws and regulations.This article addresses the right of persons who do not identify themselves with their registered sex to change it, as well as their first names in the public records, adapting them to their self-perceived gender. The practical difficulties that the non-publication of the entire content of the Brazilian Supreme Court decision, which allowed that change in a comprehensive manner to all citizens, caused for the establishment of this right when facing the Civil Registries is also taken into account. Another issue is the solution given administratively in a pioneering way by the Ceará Court of Justice and, later, by the National Council of Justice, when publishing regulatory proceedings directly in the public registries, in a relatively simple and safe way. A brief comparative analysis will be carried out between the Ceará provision and the National provision. The deductive method will be used, starting from some legal norms, and, mainly, the provisions of the Ceará Court of Justice and the National Council of Justice, with analysis of its commands. A theoretical qualitative research line will be adopted, with an analysis of bibliographic sources, as well as laws and regulations

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Simulation of economic feasibility and profitability of a free stall model milk production

Avaliaram-se a rentabilidade e a viabilidade econômica da implantação de um sistema de produção de leite em free-stall. Foi realizada uma pesquisa técnico-mercadológica para definir os investimentos necessários e determinar os custos de cada fator de produção. Considerou-se um modelo de produção composto por 100 vacas em lactação, com produção média total de 2595 litros de leite por dia. O custo operacional total mensal foi de R$27.787,39, tendo a nutrição como a variável de maior relevância, representando 62,7$43.817,50 e a consequente receita líquida mensal de R$16.030,11. Observou-se rentabilidade de 12,2$131.627,39. Concluiu-se que o modelo proposto mostrou-se economicamente inviável levando-se em consideração os preços estimados.The economical profitability and viability of the implantation of a milk production system in free stall were evaluated. A technical-market analysis was done to define the necessary investment as well as to determine the costs of each production factor. A production model with 100 lactating cows averaging 2,595 liters of daily production was considered. The total monthly operational cost was R$27,781.39 showing that nutrition is the variable with higher relevance (62.7$43,817.50 was obtained and, consequently, the monthly net income (NI)was R$16,030.11. A 12.2$131,627.39. Considering the estimated prices it is concluded that the proposed model was economically unfeasible

Simulation of economic feasibility and profitability of a free stall model milk production

Avaliaram-se a rentabilidade e a viabilidade econômica da implantação de um sistema de produção de leite em free-stall. Foi realizada uma pesquisa técnico-mercadológica para definir os investimentos necessários e determinar os custos de cada fator de produção. Considerou-se um modelo de produção composto por 100 vacas em lactação, com produção média total de 2595 litros de leite por dia. O custo operacional total mensal foi de R$27.787,39, tendo a nutrição como a variável de maior relevância, representando 62,7$43.817,50 e a consequente receita líquida mensal de R$16.030,11. Observou-se rentabilidade de 12,2$131.627,39. Concluiu-se que o modelo proposto mostrou-se economicamente inviável levando-se em consideração os preços estimados.The economical profitability and viability of the implantation of a milk production system in free stall were evaluated. A technical-market analysis was done to define the necessary investment as well as to determine the costs of each production factor. A production model with 100 lactating cows averaging 2,595 liters of daily production was considered. The total monthly operational cost was R$27,781.39 showing that nutrition is the variable with higher relevance (62.7$43,817.50 was obtained and, consequently, the monthly net income (NI)was R$16,030.11. A 12.2$131,627.39. Considering the estimated prices it is concluded that the proposed model was economically unfeasible